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pro vyhledávání: '"DaJuan L Whiteside"'
Publikováno v:
eLife, Vol 9 (2020)
Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is medi
Externí odkaz:
https://doaj.org/article/fd066d60f8264efaa942bf24035b446d
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery
Externí odkaz:
https://doaj.org/article/6c4b427687ad4141ab4421be6022f015
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is medi