Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Da-Yun Jin"'
Autor:
Da-Yun Jin, Xuejie Chen, Yizhou Liu, Craig M. Williams, Lars C. Pedersen, Darrel W. Stafford, Jian-Ke Tie
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The authors develop a Vitamin K-dependent apoptotic reporter cell line for large-scale screening of enzymes associated with Vitamin K-dependent carboxylation and identify ferroptosis suppressor protein 1 (FSP1) as responsible for warfarin-resistant v
Externí odkaz:
https://doaj.org/article/8176caccff17479fb987b36f3a6e75c6
Publikováno v:
Haematologica, Vol 105, Iss 8 (2020)
Vitamin K-dependent carboxylation is a post-translational modification essential for the biological function of coagulation factors. Defects in carboxylation are mainly associated with bleeding disorders. With the discovery of new vitamin K-dependent
Externí odkaz:
https://doaj.org/article/4cb023eb7e4a4deba84302d17f493bf4
Autor:
Da-Yun Jin, Xuejie Chen, Yizhou Liu, Craig M. Williams, Lars C. Pedersen, Darrel W. Stafford, Jian-Ke Tie
Vitamin K is a vital micronutrient implicated in a variety of human diseases1. Warfarin, a vitamin K antagonist, is the most commonly prescribed oral anticoagulant2. Warfarin exerts its effect by inhibiting vitamin K epoxide reductase (VKOR) leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97bb1b834e67f1139be86c9a7af3349a
https://doi.org/10.21203/rs.3.rs-2039668/v1
https://doi.org/10.21203/rs.3.rs-2039668/v1
Autor:
Darrel W. Stafford, Xuejie Chen, G. Paul Savage, Jian Ke Tie, Da Yun Jin, Natsuko Furukawa, Craig M. Williams, Yizhou Liu, Yoshitomo Suhara
Publikováno v:
J Thromb Haemost
Background Vitamin K antagonists (VKAs), such as warfarin, have remained the cornerstone of oral anticoagulation therapy in the prevention and treatment of thromboembolism for more than half a century. They function by impairing the biosynthesis of v
Autor:
Jian Ke Tie, Darrel W. Stafford, Yoshitomo Suhara, Natsuko Furukawa, Xuejie Chen, Craig M. Williams, Da-Yun Jin, Yizhou Liu
Publikováno v:
FEBS J
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) is responsible for the biosynthesis of menaquinone-4 (MK-4), a cofactor for extrahepatic carboxylation of vitamin K-dependent (VKD) proteins. Genetic variations of UBIAD1 are mainly associat
Publikováno v:
Blood, 137(4), 533-543. The American Society of Hematology
Blood
Blood
γ-Glutamyl carboxylase (GGCX) is an integral membrane protein that catalyzes posttranslational carboxylation of a number of vitamin K–dependent (VKD) proteins involved in a wide variety of physiologic processes, including blood coagulation, vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d092f850c16c24849b973dbed5590c9
https://cris.maastrichtuniversity.nl/en/publications/462c5588-5152-44c3-a417-e30a64c31d90
https://cris.maastrichtuniversity.nl/en/publications/462c5588-5152-44c3-a417-e30a64c31d90
Publikováno v:
Blood. 132:647-657
Vitamin K epoxide reductase (VKOR), an endoplasmic reticulum membrane protein, is the key enzyme for vitamin K–dependent carboxylation, a posttranslational modification that is essential for the biological functions of coagulation factors. VKOR is
Autor:
Darrel W. Stafford, Xue Bai, Xuejie Chen, Keping Hu, Da-Yun Jin, Brian O. Ingram, Zhenyu Hao, Jian Ke Tie, Caihong Li
Publikováno v:
Blood
Drug-induced bleeding disorders contribute to substantial morbidity and mortality. Antithrombotic agents that cause unintended bleeding of obvious cause are relatively easy to control. However, the mechanisms of most drug-induced bleeding disorders a
Autor:
Xuejie Chen, G. Paul Savage, Da-Yun Jin, Hui Xing, Sevan D. Houston, Jian Ke Tie, Craig M. Williams
Publikováno v:
Bioorg Med Chem Lett
Despite the difficulty in administering a safe dose regimen and reports of emerging resistance, warfarin (1) remains the most widely-used oral anticoagulant for the prevention and treatment of thrombosis in humans globally. Systematic substitution of