Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Da-Yuan Chen"'
Autor:
Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B. Taylor, Matteo Gentili, Gabrielle M. Hernandez, Leah R. Pearlman, Matthew R. Bauer, Charles M. Rice, Karl R. Clauser, Nir Hacohen, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113596- (2024)
Summary: Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavir
Externí odkaz:
https://doaj.org/article/db8ea015b89d430fb372f8118aea4ea2
Autor:
Lin Lin, Da-Yuan Chen, Christina Scartelli, Huanzhang Xie, Glenn Merrill-Skoloff, Moua Yang, Lijun Sun, Mohsan Saeed, Robert Flaumenhaft
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107602- (2023)
Summary: Plant-based flavonoids have been evaluated as inhibitors of β-coronavirus replication and as therapies for COVID-19 on the basis of their safety profile and widespread availability. The SARS-CoV-2 main protease (Mpro) has been implicated as
Externí odkaz:
https://doaj.org/article/39b04371d6844ffb8a5d50a2ddaf2484
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT We recently reported that mutations in both the spike glycoprotein and nonstructural protein 6 (nsp6) were associated with attenuation of the SARS-CoV-2 Omicron BA.1 variant. While mutations in spike allow evasion of neutralizing antibodies
Externí odkaz:
https://doaj.org/article/0e07760b8ada426fa4eee8b7f1d2c1d7
Autor:
Da-Yuan Chen, Jacquelyn Turcinovic, Shuchen Feng, Devin J. Kenney, Chue Vin Chin, Manish C. Choudhary, Hasahn L. Conway, Marc Semaan, Brianna J. Close, Alexander H. Tavares, Scott Seitz, Nazimuddin Khan, Sebastian Kapell, Nicholas A. Crossland, Jonathan Z. Li, Florian Douam, Susan C. Baker, John H. Connor, Mohsan Saeed
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106634- (2023)
Summary: A simple and robust cell culture system is essential for generating authentic SARS-CoV-2 stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and preparation of inactivated vaccines. Evidence suggests that Vero E6,
Externí odkaz:
https://doaj.org/article/4ef512ed285e4127ae84089843aedd7f
Autor:
Shira Weingarten-Gabbay, Leah R. Pearlman, Da-Yuan Chen, Susan Klaeger, Hannah B. Taylor, Nicole L. Welch, Derin B. Keskin, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101910- (2022)
Summary: Immunopeptidome profiling of infected cells is a powerful technique for detecting viral peptides that are naturally processed and loaded onto class I human leukocyte antigens (HLAs-I). Here, we provide a protocol for preparing samples for im
Externí odkaz:
https://doaj.org/article/a80517e85925451787c3e331aa4a5355
Autor:
Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O’Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D. Weeks, Florian Douam, Mohsan Saeed, Ali H. Munawar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, larg
Externí odkaz:
https://doaj.org/article/e07d8710ce004328ab2ec83a48a74f35
Autor:
Monir Ejemel, Qi Li, Shurong Hou, Zachary A. Schiller, Julia A. Tree, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Karen R. Buttigieg, Michael J. Elmore, Kerry Godwin, Naomi Coombes, Jacqueline R. Toomey, Ryan Schneider, Anudeep S. Ramchetty, Brianna J. Close, Da-Yuan Chen, Hasahn L. Conway, Mohsan Saeed, Chandrashekar Ganesa, Miles W. Carroll, Lisa A. Cavacini, Mark S. Klempner, Celia A. Schiffer, Yang Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.
Externí odkaz:
https://doaj.org/article/97644dca295e44a19fa5676282d05155
Autor:
Da-Yuan Chen, Matloob Husain
Publikováno v:
Viruses, Vol 12, Iss 1, p 87 (2020)
Influenza A virus (IAV) exploits host factors to multiply and cause disease. An in-depth knowledge of this interaction of IAV with the host will aid the development of anti-IAV intervention strategies. Previously, we demonstrated that host cortactin,
Externí odkaz:
https://doaj.org/article/8bb74b2d51834aa4acc8e9cee24cd011
Autor:
Tzu-Yen Chen, Da-Yuan Chen, Hsiao-Wei Wen, Jun-Lin Ou, Shyan-Song Chiou, Jo-Mei Chen, Min-Liang Wong, Wei-Li Hsu
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62482 (2013)
Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA) activity. This s
Externí odkaz:
https://doaj.org/article/20a29772f3134e8aa22048eb11242cbc
Autor:
Gang Chang, Yi-Liang Miao, Yu Zhang, Sheng Liu, Zhaohui Kou, Junjun Ding, Da-Yuan Chen, Qing-Yuan Sun, Shaorong Gao
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10320 (2010)
Somatic cell nuclear transfer (SCNT) has been proved capable of reprogramming various differentiated somatic cells into pluripotent stem cells. Recently, induced pluripotent stem cells (iPS) have been successfully derived from mouse and human somatic
Externí odkaz:
https://doaj.org/article/52acda78b8ec4e3eaafacb1f94ad69a5