Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Da-Qiang Li"'
Autor:
Li Liao, Ling Deng, Yin‐Ling Zhang, Shao‐Ying Yang, Lisa Andriani, Shu‐Yuan Hu, Fang‐Lin Zhang, Zhi‐Min Shao, Da‐Qiang Li
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background Triple‐negative breast cancer (TNBC) presents the most challenging subtype of all breast cancers because of its aggressive clinical phenotypes and absence of viable therapy targets. In order to identify effective molecular targe
Externí odkaz:
https://doaj.org/article/bba22e7a57054b5cbc38712a0f7fadb4
Autor:
Shao‐Ying Yang, Yi‐Fan Xie, Tai‐Mei Zhang, Ling Deng, Li Liao, Shu‐Yuan Hu, Yin‐Ling Zhang, Fang‐Lin Zhang, Da‐Qiang Li
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1602-1615 (2023)
Abstract Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, which is characterized by high heterogeneity and metabolic dysregulation. Inositol monophosphatase 1(IMPA1) is critical for the metabolism of inositol, w
Externí odkaz:
https://doaj.org/article/2abf0b6553174b72a49b2d1c5791792a
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been implicated in Hutchinson-Gilford progeria syndrome and human cancer. We and others recently dem
Externí odkaz:
https://doaj.org/article/48d0654f43ac4fe68e6086e31043bcdf
Autor:
Yin-Ling Zhang, Ling Deng, Li Liao, Shao-Ying Yang, Shu-Yuan Hu, Yan Ning, Fang-Lin Zhang, Da-Qiang Li
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-9 (2022)
Abstract Triple-negative breast cancer (TNBC) is a highly lethal disease due to aggressive clinical phenotype and the lack of validated therapeutic targets. Our recent quantitative proteomic analysis of 90 cases of TNBC tissues and 72 cases of matche
Externí odkaz:
https://doaj.org/article/6c19fc6134bf409ca39a97ac48e55662
Autor:
Shu‐Yuan Hu, Jin‐Xian Qian, Shao‐Ying Yang, Lisa Andriani, Li Liao, Ling Deng, Min‐Ying Huang, Yin‐Ling Zhang, Fang‐Lin Zhang, Zhi‐Min Shao, Da‐Qiang Li
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)
Abstract Background Microtubule‐targeing agents (MTAs), such as paclitaxel (PTX) and vincristine (VCR), kill cancer cells through activtion of the spindle assembly checkpoint (SAC) and induction of mitotic arrest, but the development of resistance
Externí odkaz:
https://doaj.org/article/5da9638651f84a87ab6b695658a65828
Autor:
Shao-Ying Yang, Li Liao, Shu-Yuan Hu, Ling Deng, Lisa Andriani, Tai-Mei Zhang, Yin-Ling Zhang, Xiao-Yan Ma, Fang-Lin Zhang, Ying-Ying Liu, Da-Qiang Li
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14566 (2023)
Triple-negative breast cancer (TNBC) is the most fatal subtype of breast cancer; however, effective treatment strategies for TNBC are lacking. Therefore, it is important to explore the mechanism of TNBC metastasis and identify its therapeutic targets
Externí odkaz:
https://doaj.org/article/3d095eabf165409fb99d1fd3adc2c3ff
Autor:
Fan Yang, Rui Sun, Zeng Hou, Fang‐Lin Zhang, Yi Xiao, Yun‐Song Yang, Shao‐Ying Yang, Yi‐Fan Xie, Ying‐Ying Liu, Cheng Luo, Guang‐Yu Liu, Zhi‐Min Shao, Da‐Qiang Li
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Abstract Aims MORC family CW‐type zinc finger 2 (MORC2), a GHKL‐type ATPase, is aberrantly upregulated in multiple types of human tumors with profound effects on cancer aggressiveness, therapeutic resistance, and clinical outcome, thus making it
Externí odkaz:
https://doaj.org/article/74c9297b325c4c5c89950cc75fdb96a8
Autor:
Guan-Tian Lang, Yi-Zhou Jiang, Jin-Xiu Shi, Fan Yang, Xiao-Guang Li, Yu-Chen Pei, Chen-Hui Zhang, Ding Ma, Yi Xiao, Peng-Chen Hu, Hai Wang, Yun-Song Yang, Lin-Wei Guo, Xun-Xi Lu, Meng-Zhu Xue, Peng Wang, A-Yong Cao, Hong Ling, Zhong-Hua Wang, Ke-Da Yu, Gen-Hong Di, Da-Qiang Li, Yun-Jin Wang, Ying Yu, Le-Ming Shi, Xin Hu, Wei Huang, Zhi-Ming Shao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hip
Externí odkaz:
https://doaj.org/article/61dd0a122435489e99726b2dc7d128dc
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-18 (2020)
Abstract Background Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have shown signific
Externí odkaz:
https://doaj.org/article/f24e61bb66e348f5b2e76c28a3f516b4
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Decondesation of the highly compacted chromatin architecture is essential for efficient DNA repair, but how this is achieved remains largely unknown. Here, we report that microrchidia family CW-type zinc finger protein 2 (MORC2), a newly ide
Externí odkaz:
https://doaj.org/article/f8ec9b78838b4d2eaf467ce3b4b3b0cc