Výsledky vyhledávání

Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance

Autor: Jing-Jing Xu, Da-Lie Ma, Cen Qiu, Ling Huang, Xiaohong Liu, Xiao-Wei Hou, Chen-Guang Bai

Publikováno v: Oncology Letters

KIT autophosphorylation caused by mutation of KIT is considered to be a critical mechanism for the oncogenesis of gastrointestinal stromal tumors (GISTs). However, little is known regarding whether stem cell factor (SCF), the KIT ligand, is able to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730df343add4939476c1fda0d585fb8b
http://europepmc.org/articles/PMC3572958

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The expression of KIT receptor dimers in gastrointestinal stromal tumors independent of c-kit mutation and SCF expression is associated with high-risk stratification

Autor: Da Lie Ma, Xiaohong Liu, Cen Qiu, Chen-Guang Bai

Publikováno v: Oncology Letters. 4:805-811

Although the dimerization of KIT, a receptor tyrosine kinase, plays a major role in a number of tumors, correlations between the clinicopathological parameters and KIT receptor dimers have not been identified. In the current study, a method for the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65e90a15dd27ab556970bd9653dd089
https://doi.org/10.3892/ol.2012.797

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A novel PDGFRA mutation in gastrointestinal stromal tumours, L839P, is sensitive to imatinib in vitro

Autor: Da-Lie Ma, Xiaohong Liu, Jing Zhao, Yan Zhu, Cen Qiu, Chen-Guang Bai, Jianming Zheng, Jing-Jing Xu

Publikováno v: Oncology letters. 3(5)

Evidence suggests that different types of mutation in gastrointestinal stromal tumours (GISTs) correlate with different response rates to imatinib (Glivec, STI571). The purpose of this study was to explore the sensitivity of the PDGFRA(L839P) mutant,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dc715f9d624ffe29ae9e3b1e26628b
https://pubmed.ncbi.nlm.nih.gov/22783407

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Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma

Autor: Peng Zhang, Qiang Li, Ling Huang, Da-Lie Ma, Yiping Han

Napsin A is a newly discovered functional aspartic proteinase that is expressed in normal lung parenchyma in type II pneumocytes and is thought to be associated with primary lung adenocarcinoma. Thyroid transcription factor-1 (TTF-1) is a widely used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a206464a06c9afa80f8e4598483529
https://europepmc.org/articles/PMC3436431/

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[Transforming effect of PDGFRA gene mutant on the cell function in gastrointestinal stromal tumor]

Autor: Lei, Yang, Chen-Guang, Bai, Xiao-Wei, Hou, Xiao-Hong, Liu, Da-Lie, Ma

Publikováno v: Zhonghua zhong liu za zhi [Chinese journal of oncology]. 31(7)

To explore the effect of malignant transformation of the L839P, a new mutation site of the PDGFRA gene, on the pathogenesis of gastrointestinal stromal tumors.All recombinant plasmids were stably transfected into CHO cells by liposomes. Western blott

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f9b21354fd3161d032b0ce43c6ed236
https://pubmed.ncbi.nlm.nih.gov/19950696

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