Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity.

Autor: Poggetti V; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Angeloni E; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Germelli L; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Natale B; DiSTABiF, University of Campania Luigi Vanvitelli, Via Vivaldi, 43, 81100 Caserta, Italy., Waqas M; DiSTABiF, University of Campania Luigi Vanvitelli, Via Vivaldi, 43, 81100 Caserta, Italy., Sarno G; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy., Angeli A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Via U. Schiff, 6, Sesto Fiorentino, 50019 Firenze, Italy., Daniele S; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Salerno S; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Barresi E; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Cosconati S; DiSTABiF, University of Campania Luigi Vanvitelli, Via Vivaldi, 43, 81100 Caserta, Italy., Castellano S; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy., Da Pozzo E; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Costa B; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Polo Scientifico, University of Florence, Via U. Schiff, 6, Sesto Fiorentino, 50019 Firenze, Italy., Da Settimo F; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy., Taliani S; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.

The Citrus flavanone naringenin prolongs the lifespan in C. elegans and slows signs of brain aging in mice.

Autor: Piragine E; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center 'Nutrafood-Nutraceuticals and Food for Health', University of Pisa, Italy. Electronic address: eugenia.piragine@unipi.it., De Felice M; Department of Pharmacy, University of Pisa, Italy. Electronic address: martina.defelice@phd.unipi.it., Germelli L; Department of Pharmacy, University of Pisa, Italy. Electronic address: lorenzo.germelli@farm.unipi.it., Brinkmann V; Institute of Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany. Electronic address: brinkmann.van@gmail.com., Flori L; Department of Pharmacy, University of Pisa, Italy. Electronic address: lorenzo.flori@farm.unipi.it., Martini C; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center 'Nutrafood-Nutraceuticals and Food for Health', University of Pisa, Italy. Electronic address: claudia.martini@unipi.it., Calderone V; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center 'Biology and Pathology of Ageing', University of Pisa, Italy; Interdepartmental Research Center 'Nutrafood-Nutraceuticals and Food for Health', University of Pisa, Italy. Electronic address: vincenzo.calderone@unipi.it., Ventura N; Institute of Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germany. Electronic address: natascia.ventura@uni-duesseldorf.de., Da Pozzo E; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center 'Nutrafood-Nutraceuticals and Food for Health', University of Pisa, Italy. Electronic address: eleonora.dapozzo@unipi.it., Testai L; Department of Pharmacy, University of Pisa, Italy; Interdepartmental Research Center 'Biology and Pathology of Ageing', University of Pisa, Italy; Interdepartmental Research Center 'Nutrafood-Nutraceuticals and Food for Health', University of Pisa, Italy. Electronic address: lara.testai@unipi.it.

Publikováno v: Experimental gerontology [Exp Gerontol] 2024 Sep; Vol. 194, pp. 112495. Date of Electronic Publication: 2024 Jun 18.

Human oligodendrocyte-like cell differentiation is promoted by TSPO-mediated endogenous steroidogenesis.

Autor: Tremolanti C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address: chiara.tremolanti@unipi.it., Angeloni E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address: elisa.angeloni@phd.unipi.it., Da Pozzo E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Center for Instrument Sharing of the University of Pisa (CISUP), Via Santa Maria 53, 56126 Pisa. Italy. Electronic address: eleonora.dapozzo@unipi.it., Germelli L; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address: lorenzo.germelli@farm.unipi.it., Giacomelli C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Center for Instrument Sharing of the University of Pisa (CISUP), Via Santa Maria 53, 56126 Pisa. Italy. Electronic address: chiara.giacomelli@unipi.it., Scalzi E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Taliani S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address: sabrina.taliani@unipi.it., Da Settimo F; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Center for Instrument Sharing of the University of Pisa (CISUP), Via Santa Maria 53, 56126 Pisa. Italy. Electronic address: federico.dasettimo@unipi.it., Mensah-Nyagan AG; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000 Strasbourg, France. Electronic address: gmensah@unistra.fr., Martini C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Center for Instrument Sharing of the University of Pisa (CISUP), Via Santa Maria 53, 56126 Pisa. Italy. Electronic address: claudia.martini@unipi.it., Costa B; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Center for Instrument Sharing of the University of Pisa (CISUP), Via Santa Maria 53, 56126 Pisa. Italy. Electronic address: barbara.costa@unipi.it.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Jun; Vol. 1870 (5), pp. 167174. Date of Electronic Publication: 2024 Apr 15.

Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis.

Autor: Tremolanti C; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000, Strasbourg, France.; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy., Cavallini C; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000, Strasbourg, France.; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy., Meyer L; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000, Strasbourg, France., Klein C; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000, Strasbourg, France., Da Pozzo E; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.; CISUP - Centre for Instrumentation Sharing - University of Pisa, Lungarno Pacinotti 43, 56126, Pisa, Italy., Costa B; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.; CISUP - Centre for Instrumentation Sharing - University of Pisa, Lungarno Pacinotti 43, 56126, Pisa, Italy., Germelli L; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy., Taliani S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.; CISUP - Centre for Instrumentation Sharing - University of Pisa, Lungarno Pacinotti 43, 56126, Pisa, Italy., Patte-Mensah C; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000, Strasbourg, France., Mensah-Nyagan AG; Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment CRBS de la Faculté de Médecine, 1 rue Eugène Boeckel, 67 000, Strasbourg, France. gmensah@unistra.fr.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2022 Mar; Vol. 59 (3), pp. 1744-1765. Date of Electronic Publication: 2022 Jan 11.

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