Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair

Autor: Da Ching Tsai, Chwan Yau Luo, Yi-Dong Lin, Patrick C.H. Hsieh, Erika I. H. Wei, Ying Chang Hsueh, Matthew L. Springer, Ming Long Yeh, Ming Jer Tang, Yu Ning Hu, Jieh Neng Wang, Min Yao Chang

Publikováno v: Science translational medicine, vol 4, iss 146
Lin, YD; Luo, CY; Hu, YN; Yeh, ML; Hsueh, YC; Chang, MY; et al.(2012). Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair. Science Translational Medicine, 4(146). doi: 10.1126/scitranslmed.3003841. UCSF: Retrieved from: http://www.escholarship.org/uc/item/094719gd

Angiogenic therapy is a promising approach for tissue repair and regeneration. However, recent clinical trials with protein delivery or gene therapy to promote angiogenesis have failed to provide therapeutic effects. A key factor for achieving effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f194e62d4206c6212640d3cba1a741
https://escholarship.org/uc/item/094719gd

Intramyocardial peptide nanofiber injection improves postinfarction ventricular remodeling and efficacy of bone marrow cell therapy in pigs

Autor: Ting Yu Chu, Yi-Dong Lin, Tin Kan Hung, Chwan Yau Luo, Hua Lin Wu, Da Ching Tsai, Kung Chao Chang, Yu Jen Yang, Patrick C.H. Hsieh, Min Yao Chang, Jyh Hong Chen, Tsai Yun Chen, Alan C.L. Tang, Ming Long Yeh, Yen Wen Liu, Ya Yun Shih

Publikováno v: Circulation. 122

Background— Growing evidence suggests that intramyocardial biomaterial injection improves cardiac functions after myocardial infarction (MI) in rodents. Cell therapy is another promising approach to treat MI, although poor retention of transplanted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c8edf4f5248318e76fe97f8be8aca2
https://pubmed.ncbi.nlm.nih.gov/20837904