Zobrazeno 1 - 10
of 1 945
pro vyhledávání: '"DYRK1A"'
Autor:
Pinhua Wang, Sunayana Sarkar, Menghuan Zhang, Tingting Xiao, Fenhua Kong, Zhe Zhang, Deepa Balasubramanian, Nandan Jayaram, Sayantan Datta, Ruyu He, Ping Wu, Peng Chao, Ying Zhang, Michael Washburn, Laurence A Florens, Sonal Nagarkar-Jaiswal, Manish Jaiswal, Man Mohan
Publikováno v:
eLife, Vol 12 (2024)
DYRK1A, a ubiquitously expressed kinase, is linked to the dominant intellectual developmental disorder, microcephaly, and Down syndrome in humans. It regulates numerous cellular processes such as cell cycle, vesicle trafficking, and microtubule assem
Externí odkaz:
https://doaj.org/article/4350b6428f4542ff8d1561e278254bd9
Autor:
Hyun-ju Lee, Jeong-Woo Hwang, Jieun Kim, A-Ran Jo, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang, Su-Jeong Kim, Jeong-Heon Song, Hyang-Sook Hoe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionErlotinib is an epidermal growth factor receptor (EGFR) inhibitor that is approved by the FDA to treat non-small cell lung cancer (NSCLC). Several membrane receptors, including EGFR, interact with amyloid β (Aβ), raising the possibility
Externí odkaz:
https://doaj.org/article/c1c97c411bab43c1b760afb8eccbc166
Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model
Autor:
Jonathan M. LaCombe, Kourtney Sloan, Jared R. Thomas, Matthew P. Blackwell, Isabella Crawford, Flannery Bishop, Joseph M. Wallace, Randall J. Roper
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/1572a482389742a1848b82c57d5c59f0
Autor:
Huang-Ju Tu, Min-Wu Chao, Cheng-Chung Lee, Chao-Shiang Peng, Yi-Wen Wu, Tony Eight Lin, Yu-Wei Chang, Shih-Chung Yen, Kai-Cheng Hsu, Shiow-Lin Pan, Wei-Chun HuangFu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. Although the developm
Externí odkaz:
https://doaj.org/article/5af157fcd59d43dfa082d52baafe6400
Publikováno v:
Clinical and Experimental Hypertension, Vol 46, Iss 1 (2024)
ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK
Externí odkaz:
https://doaj.org/article/266fb4cd90934032acb25f8111f469ee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Down syndrome is a genetic-based disorder that results from the triplication of chromosome 21, leading to an overexpression of many triplicated genes, including the gene encoding Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A).
Externí odkaz:
https://doaj.org/article/7bd9e0f2f9304a299516f800d438406f
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Autor:
Doaa Ibrahim, Nooralhuda Yahya
Publikováno v:
المجلة العراقية للصيدلة, Vol 20, Iss 2, Pp 168-173 (2023)
Background: Diabetes mellitus is a common metabolic disorder characterized by chronic high blood sugar levels due to impaired insulin secretion or action. Existing diabetic medications have limitations, including high costs and the risk of hypoglycem
Externí odkaz:
https://doaj.org/article/31ef80a002d14f9896a86cac672974c5
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 39, Iss 12, Pp 1190-1199 (2023)
Abstract This study aimed to explore the role and mechanism of DYRK1a regulating ferroptosis of cardiomyocytes during myocardial ischemia–reperfusion injury (MIRI). H9c2 cells treated with oxygen–glucose deprivation/reoxygenation (OGD/R) were use
Externí odkaz:
https://doaj.org/article/fa8b18bede904723a1778599a25194bf
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