SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Autor: Victoria Jane Hall, Sarah Foulkes, Andre Charlett, Ana Atti, Edward J M Monk, Ruth Simmons, Edgar Wellington, Michelle J Cole, Ayoub Saei, Blanche Oguti, Katie Munro, Sarah Wallace, Peter D Kirwan, Madhumita Shrotri, Amoolya Vusirikala, Sakib Rokadiya, Meaghan Kall, Maria Zambon, Mary Ramsay, Tim Brooks, Colin S Brown, Meera A Chand, Susan Hopkins, N Andrews, A Atti, H Aziz, T Brooks, CS Brown, D Camero, C Carr, MA Chand, A Charlett, H Crawford, M Cole, J Conneely, S D'Arcangelo, J Ellis, S Evans, S Foulkes, N Gillson, R Gopal, L Hall, VJ Hall, P Harrington, S Hopkins, J Hewson, K Hoschler, D Ironmonger, J Islam, M Kall, I Karagiannis, O Kay, J Khawam, E King, P Kirwan, R Kyffin, A Lackenby, M Lattimore, E Linley, J Lopez-Bernal, L Mabey, R McGregor, S Miah, EJM Monk, K Munro, Z Naheed, A Nissr, AM O'Connell, B Oguti, H Okafor, S Organ, J Osbourne, A Otter, M Patel, S Platt, D Pople, K Potts, M Ramsay, J Robotham, S Rokadiya, C Rowe, A Saei, G Sebbage, A Semper, M Shrotri, R Simmons, A Soriano, P Staves, S Taylor, A Taylor, A Tengbe, S Tonge, A Vusirikala, S Wallace, E Wellington, M Zambon, D Corrigan, M Sartaj, L Cromey, S Campbell, K Braithwaite, L Price, L Haahr, S Stewart, ED Lacey, L Partridge, G Stevens, Y Ellis, H Hodgson, C Norman, B Larru, S Mcwilliam, S Winchester, P Cieciwa, A Pai, C Loughrey, A Watt, F Adair, A Hawkins, A Grant, R Temple-Purcell, J Howard, N Slawson, C Subudhi, S Davies, A Bexley, R Penn, N Wong, G Boyd, A Rajgopal, A Arenas-Pinto, R Matthews, A Whileman, R Laugharne, J Ledger, T Barnes, C Jones, D Botes, N Chitalia, S Akhtar, G Harrison, S Horne, N Walker, K Agwuh, V Maxwell, J Graves, S Williams, A O'Kelly, P Ridley, A Cowley, H Johnstone, P Swift, J Democratis, M Meda, C Callens, S Beazer, S Hams, V Irvine, B Chandrasekaran, C Forsyth, J Radmore, C Thomas, K Brown, S Roberts, P Burns, K Gajee, TM Byrne, F Sanderson, S Knight, E Macnaughton, BJL Burton, H Smith, R Chaudhuri, K Hollinshead, RJ Shorten, A Swan, C Favager, J Murira, S Baillon, S Hamer, K Gantert, J Russell, D Brennan, A Dave, A Chawla, F Westell, D Adeboyeku, P Papineni, C Pegg, M Williams, S Ahmad, S Ingram, C Gabriel, K Pagget, G Maloney, J Ashcroft, I Del Rosario, R Crosby-Nwaobi, C Reeks, S Fowler, L Prentice, M Spears, G McKerron, K McLelland-Brooks, J Anderson, S Donaldson, K Templeton, L Coke, N Elumogo, J Elliott, D Padgett, M Mirfenderesky, A Cross, J Price, S Joyce, I Sinanovic, M Howard, T Lewis, P Cowling, D Potoczna, S Brand, L Sheridan, B Wadams, A Lloyd, J Mouland, J Giles, G Pottinger, H Coles, M Joseph, M Lee, S Orr, H Chenoweth, C Auckland, R Lear, T Mahungu, A Rodger, K Penny-Thomas, S Pai, J Zamikula, E Smith, S Stone, E Boldock, D Howcroft, C Thompson, M Aga, P Domingos, S Gormley, C Kerrison, L Marsh, S Tazzyman, L Allsop, S Ambalkar, M Beekes, S Jose, J Tomlinson, A Jones, C Price, J Pepperell, M Schultz, J Day, A Boulos, E Defever, D McCracken, K Gray, A Houston, T Planche, R Pritchard Jones, Diane Wycherley, S Bennett, J Marrs, K Nimako, B Stewart, N Kalakonda, S Khanduri, A Ashby, M Holden, N Mahabir, J Harwood, B Payne, K Court, N Staines, R Longfellow, ME Green, LE Hughes, M Halkes, P Mercer, A Roebuck, E Wilson-Davies, L Gallego, R Lazarus, N Aldridge, L Berry, F Game, T Reynolds, C Holmes, M Wiselka, A Higham, M Booth, C Duff, J Alderton, H Jory, E Virgilio, T Chin, MZ Qazzafi, AM Moody, R Tilley, T Donaghy, K Shipman, R Sierra, N Jones, G Mills, D Harvey, YWJ Huang, J Birch, L Robinson, S Board, A Broadley, C Laven, N Todd, DW Eyre, K Jeffery, S Dunachie, C Duncan, P Klenerman, L Turtle, T De Silva, H Baxendale, JL Heeney

Publikováno v: Lancet (London, England)

Background Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810fe23610baf07d51b6f7ff6cb383ce
https://doi.org/10.1016/s0140-6736(21)00675-9

Epidemiological data and genome sequencing reveals that nosocomial transmission of SARS-CoV-2 is underestimated and mostly mediated by a small number of highly infectious individuals

Autor: Kevin K Chau, Philippa C Matthews, Nicholas D Sanderson, Denise O'Donnell, Katie Jeffery, Tim E. A. Peto, Gillian Rodger, Lisa Butcher, Derrick W. Crook, Timothy M. Walker, Nicole Stoesser, Teresa L Street, Fiona Warren, Bede Constantinides, Jeremy Swann, Sarah Hoosdally, Sheila F Lumley, DW Eyre, Anne-Marie O'Donnell, Control team

Publikováno v: The Journal of Infection

Objectives: Despite robust efforts, patients and staff acquire SARS-CoV-2 infection in hospitals. We investigated whether whole-genome sequencing enhanced the epidemiological investigation of healthcare-associated SARS-CoV-2 acquisition. Methods: Fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105564c9136bf749fd2b236645a0ab0b
https://ora.ox.ac.uk/objects/uuid:5aec22d4-99c0-47f6-a018-ef2560f10999

Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status

Autor: Anne-Sophie Walker, David I. Stuart, Daniel Ebner, S F Lumley, T Peto, Brian D. Marsden, Anita Justice, Philippa C Matthews, Stephanie B Hatch, Stuart Cox, Alison Howarth, Timothy M Walker, Derrick W. Crook, Gerald Jesuthasan, Koen B. Pouwels, Denise O'Donnell, Sarah Hoosdally, DW Eyre, Jia Wei, E Y Jones, Nicole Stoesser, Tim James, Katie Jeffery

Publikováno v: Clinical Microbiology and Infection

Objectives We investigated determinants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-spike IgG responses in healthcare workers (HCWs) following one or two doses of Pfizer–BioNTech or Oxford–AstraZeneca vaccines. Methods HC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e7701ff2184a33ac52876defa18a44
https://doi.org/10.1016/j.cmi.2021.05.041

P41 The COPD Assessment Test (CAT) used to evaluate outcome in pulmonary rehabilitation

Autor: Maxine Hardinge, E Tucker, DW Eyre, QC Jones, J Young, J Riley

Publikováno v: Thorax. 65:A94-A94

Introduction Outcomes in pulmonary rehabilitation (PR) can be evaluated using exercise performance tests and health status measures such as the St George′s Respiratory Questionnaire (SGRQ) and Hospital Anxiety and Depression Score (HADS). The SGRQ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a15f9b84ba34a264230861f3c530bf38
https://doi.org/10.1136/thx.2010.150961.41

Predicting future hospital antimicrobial resistance prevalence using machine learning.

Autor: Vihta KD; Modernising Medical Microbiology, Experimental Medicine, Nuffield Department of Medicine, Level 7 Research Offices, John Radcliffe Hospital, Headley Way, University of Oxford, Oxford, UK. karina.vihta@gmail.com.; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK. karina.vihta@gmail.com.; Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. karina.vihta@gmail.com., Pritchard E; Modernising Medical Microbiology, Experimental Medicine, Nuffield Department of Medicine, Level 7 Research Offices, John Radcliffe Hospital, Headley Way, University of Oxford, Oxford, UK.; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK., Pouwels KB; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK.; Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hopkins S; Healthcare-associated infections, Fungal, Antimicrobial resistance, Antimicrobial usage, & Sepsis Division, UK Health Security Agency, London, UK., Guy RL; Healthcare-associated infections, Fungal, Antimicrobial resistance, Antimicrobial usage, & Sepsis Division, UK Health Security Agency, London, UK., Henderson K; Healthcare-associated infections, Fungal, Antimicrobial resistance, Antimicrobial usage, & Sepsis Division, UK Health Security Agency, London, UK., Chudasama D; Healthcare-associated infections, Fungal, Antimicrobial resistance, Antimicrobial usage, & Sepsis Division, UK Health Security Agency, London, UK., Hope R; Healthcare-associated infections, Fungal, Antimicrobial resistance, Antimicrobial usage, & Sepsis Division, UK Health Security Agency, London, UK., Muller-Pebody B; Healthcare-associated infections, Fungal, Antimicrobial resistance, Antimicrobial usage, & Sepsis Division, UK Health Security Agency, London, UK., Walker AS; Modernising Medical Microbiology, Experimental Medicine, Nuffield Department of Medicine, Level 7 Research Offices, John Radcliffe Hospital, Headley Way, University of Oxford, Oxford, UK.; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK.; The National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Clifton D; Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.; OSCAR (Oxford Suzhou Centre for Advanced Research), University of Oxford, Suzhou, China., Eyre DW; Modernising Medical Microbiology, Experimental Medicine, Nuffield Department of Medicine, Level 7 Research Offices, John Radcliffe Hospital, Headley Way, University of Oxford, Oxford, UK.; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK.; The National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Oct 10; Vol. 4 (1), pp. 197. Date of Electronic Publication: 2024 Oct 10.