MD3: THE IMPACT OF REQUIRING A FIXED PERIOD OF ELIGIBILITY IN ECONOMIC AND EPIDEMIOLOGICAL STUDIES THAT UTILIZE LONGITUDINAL DATA

Autor: Albert Hauber, Susan Eaton, DW Clark, John E. Paul, Lisa McQuay

Publikováno v: Value in Health. 6:179-180

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e8043e1104ab7f5640cd0648ae4159
https://doi.org/10.1016/s1098-3015(10)63806-5

Variability in the elimination of mianserin in elderly patients

Autor: DW Clark, Richard Sainsbury, JE Kidd, J.R. Sharman, Evan J. Begg

Publikováno v: British Journal of Clinical Pharmacology. 27:445-451

1. Two studies of the elimination of mianserin are reported. 2. In the first study, the oral clearance of mianserin was measured in 15 elderly patients at steady state. In a sub-group of eight patients who completed studies at two different doses the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362e8995fbdb344c6ceb5807c7ed9ea9
https://doi.org/10.1111/j.1365-2125.1989.tb05392.x

Genome-wide analysis identifies gallstone-susceptibility loci including genes regulating gastrointestinal motility.

Autor: Fairfield CJ; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland., Drake TM; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland., Pius R; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland., Bretherick AD; MRC Human Genetics UnitInstitute of Genetics and CancerUniversity of EdinburghEdinburghScotland., Campbell A; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland.; Center for Genomic and Experimental MedicineInstitute of Genetics and CancerUniversity of EdinburghEdinburghScotland.; Health Data Research UKUniversity of EdinburghEdinburghScotland., Clark DW; Center for Global Health ResearchUsher InstituteUniversity of EdinburghEdinburghScotland., Fallowfield JA; Centre for Inflammation ResearchQueen's Medical Research InstituteUniversity of EdinburghEdinburghScotland., Hayward C; MRC Human Genetics UnitInstitute of Genetics and CancerUniversity of EdinburghEdinburghScotland., Henderson NC; Centre for Inflammation ResearchQueen's Medical Research InstituteUniversity of EdinburghEdinburghScotland., Iakovliev A; Center for Population Health SciencesUsher InstituteUniversity of EdinburghEdinburghScotland., Joshi PK; Center for Global Health ResearchUsher InstituteUniversity of EdinburghEdinburghScotland., Mills NL; Center for Cardiovascular ScienceQueen's Medical Research InstituteUniversity of EdinburghEdinburghScotland., Porteous DJ; Center for Genomic and Experimental MedicineInstitute of Genetics and CancerUniversity of EdinburghEdinburghScotland., Ramachandran P; Centre for Inflammation ResearchQueen's Medical Research InstituteUniversity of EdinburghEdinburghScotland., Semple RK; Center for Cardiovascular ScienceQueen's Medical Research InstituteUniversity of EdinburghEdinburghScotland., Shaw CA; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland., Sudlow CLW; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland., Timmers PRHJ; MRC Human Genetics UnitInstitute of Genetics and CancerUniversity of EdinburghEdinburghScotland.; Center for Global Health ResearchUsher InstituteUniversity of EdinburghEdinburghScotland., Wilson JF; MRC Human Genetics UnitInstitute of Genetics and CancerUniversity of EdinburghEdinburghScotland.; Center for Global Health ResearchUsher InstituteUniversity of EdinburghEdinburghScotland., Wigmore SJ; Department of Clinical SurgeryDivision of Health SciencesUniversity of EdinburghEdinburghScotland., Spiliopoulou A; Center for Population Health SciencesUsher InstituteUniversity of EdinburghEdinburghScotland., Harrison EM; Center for Medical InformaticsUsher InstituteUniversity of EdinburghEdinburghScotland.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2022 May; Vol. 75 (5), pp. 1081-1094. Date of Electronic Publication: 2021 Dec 10.

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.

Autor: Crawford AA; BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bankier S; BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK., Altmaier E; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Barnes CLK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Clark DW; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Ermel R; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475, Greifswald, Germany., van der Harst P; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, PO box 30.001, 9700 RB, The Netherlands., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Karhunen V; Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London, UK.; Centre for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.; Turku Institute of Advanced Studies, University of Turku, Turku, Finland., Mahajan A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College, Lambeth Palace Road, London, SE1 7EH, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada., Pietzner M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475, Greifswald, Germany., Sukhavasi K; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia., Wang CA; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW, 2308, Australia., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bjorkegren JLM; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Clinical Gene Networks AB, Stockholm, Sweden., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Eriksson J; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Helsinki, Singapore., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital University of Edinburgh, Edinburgh, EH4 2XU, Scotland., Jarvelin MR; Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London, UK.; Centre for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care and Medical Research Center, Oulu University Hospital, Oulu, Finland., McLachlan S; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Morris AP; Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Centre for Human genetics, University of Oxford, Oxford, UK., Ohlsson C; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Pennell CE; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW, 2308, Australia., Price J; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Rudan I; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Ruusalepp A; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia.; Clinical Gene Networks AB, Stockholm, Sweden., Spector T; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Tiemeier H; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Social and Behavioural Science, Harvard TH Chan School of Public Health, Boston, MA, USA., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17489, Greifswald, Germany., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital University of Edinburgh, Edinburgh, EH4 2XU, Scotland., Michoel T; Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.; Computational Biology Unit, Department of Informatics, University of Bergen, PO Box 7803, 5020, Bergen, Norway., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Walker BR; BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Brian.Walker@ncl.ac.uk.; Clinical and Translational Research Institute, Newcastle University, Newcastle upon Tyne, UK. Brian.Walker@ncl.ac.uk.

Publikováno v: Journal of human genetics [J Hum Genet] 2021 Jun; Vol. 66 (6), pp. 625-636. Date of Electronic Publication: 2021 Jan 20.

Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.

Autor: Bretherick AD; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Canela-Xandri O; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Clark DW; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Rawlik K; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Boutin TS; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Zeng Y; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China., Amador C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Navarro P; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Tenesa A; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Ponting CP; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Baillie JK; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Haley C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2020 Jul 06; Vol. 16 (7), pp. e1008785. Date of Electronic Publication: 2020 Jul 06 (Print Publication: 2020).