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pro vyhledávání: '"DUTP pyrophosphatase"'
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Publikováno v:
FEBS Letters. 583:865-871
Most dUTP pyrophosphatases (dUTPases) are homotrimers with interfaces formed between subunit surfaces, in the central channel, and by C-terminal β-strand swapping. Analysis of intersubunit interactions reveals an important cohesive role for the C-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8dfd62c66d93973da2e273922008525
https://doi.org/10.1016/j.febslet.2009.02.011
https://doi.org/10.1016/j.febslet.2009.02.011
Autor:
James R. Sellers, Beáta G. Vértessy, Judit Tóth, Ildiko Pecsi, István Simon, Judit Szabó, Scott D. Adams
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14437-14442
We investigated the potential (d)NDP/(d)NTP discrimination mechanisms in nucleotide pyrophosphatases. Here, we report that dUTPase, an essential nucleotide pyrophosphatase, uses a C-terminal P-loop-like sequence in a unique mechanism for substrate di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e3daeb7f43da7fc78a39239530b193
https://doi.org/10.1073/pnas.1013872108
https://doi.org/10.1073/pnas.1013872108
Autor:
Gergely N. Nagy, Judit Tóth, Ibolya Leveles, Beáta G. Vértessy, Anna Lopata, Enikő Takács, Veronika Harmat
Publikováno v:
FEBS Letters. 584:3047-3054
dUTP pyrophosphatases (dUTPases) are essential for genome integrity. Recent results allowed characterization of the role of conserved residues. Here we analyzed the Asp/Asn mutation within conserved Motif I of human and mycobacterial dUTPases, wherei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7220113cc9c26eec72dcff56f617ccd
https://doi.org/10.1016/j.febslet.2010.05.018
https://doi.org/10.1016/j.febslet.2010.05.018
Autor:
Marcel Kaiser, Dolores Gonzalez Pacanowska, Alex Musso-Buendia, Ian H. Gilbert, Reto Brun, Luis M. Ruiz-Pérez, Orla McCarthy, Nils Gunnar Johansson
Publikováno v:
European Journal of Medicinal Chemistry. 44:678-688
The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibition of this enzyme results in over-incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa649aa56dd3e77e9489983621f973b0
https://doi.org/10.1016/j.ejmech.2008.05.018
https://doi.org/10.1016/j.ejmech.2008.05.018
Publikováno v:
European Journal of Organic Chemistry. 2009:1082-1092
Acyclic nucleoside diphosphonate derivatives of purines and pyrimidines were prepared by Mitsunobu reaction of suitably protected heterocyclic bases with alcohols containing the (phosphonomethyl)phosphanyl moiety. Furthermore, nonhydrolyzable acyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c32932a5b61f28b772a09b65054cc931
https://doi.org/10.1002/ejoc.200800911
https://doi.org/10.1002/ejoc.200800911
Autor:
Tomoaki Mizobe, Kazuo Shirouzu, Masayoshi Kage, Satoshi Hattori, Mayumi Ono, Yoshito Akagi, Michihiko Kuwano, Takashi Yanagawa, Akihiko Kawahara
Publikováno v:
Journal of Clinical Pathology
Aims: 5-Fluorouracil (5-FU) is one of the most widely used anticancer drugs; however, the activity of 5-FU is determined by the presence of several enzymes that limit its activation or degradation, and these include dihydropyrimidine dehydrogenase (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cf92ce6c17f41e3b460793370aefaa
https://doi.org/10.1136/jcp.2008.060004
https://doi.org/10.1136/jcp.2008.060004
Autor:
Júlia Kovári, Ferenc Tölgyesi, Angéla Békési, Judit Fidy, József Nagy, Beáta G. Vértessy, Balázs Varga, Orsolya Barabas
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 71:308-319
dUTP pyrophosphatase, a preventive DNA repair enzyme, contributes to maintain the appropriate cellular dUTP/dTTP ratio by catalyzing dUTP hydrolysis. dUTPase is essential for viability in bacteria and eukaryotes alike. Identification of species-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f59a782f261a832cf161cb7c3b80fd
https://doi.org/10.1002/prot.21757
https://doi.org/10.1002/prot.21757
Publikováno v:
DNA Repair. 5:1407-1420
The steady-state levels of uracil residues in DNA extracted from strains of Escherichia coli were measured and the influence of defects in the genes for uracil-DNA glycosylase ( ung ), double-strand uracil-DNA glycosylase ( dug ), and dUTP pyrophosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec8fc7cbd8b526b180a1306d0ddb69
https://doi.org/10.1016/j.dnarep.2006.06.009
https://doi.org/10.1016/j.dnarep.2006.06.009
Autor:
Alex Musso Buendía, Alessandro Schipani, Dolores Gonzalez Pacanowska, Orla K. Mc Carthy, Luis M. Ruiz-Pérez, Reto Brun, Marcel Kaiser, Ian H. Gilbert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3809-3812
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel lib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876734f3e2d26e47a398aed67fdca0d6
https://doi.org/10.1016/j.bmcl.2006.04.027
https://doi.org/10.1016/j.bmcl.2006.04.027