NADPH, not glutathione, status modulates oxidant sensitivity in normal and glucose-6-phosphate dehydrogenase-deficient erythrocytes

Autor: Bertram H. Lubin, DT Chiu, L Zuo, Scott

Publikováno v: Blood. 77:2059-2064

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is characterized by the loss of NADPH and enhanced erythrocyte oxidant sensitivity. Historically, it has been theorized that the elevated oxidant sensitivity of G6PD-deficient erythrocytes arises as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0887cad6df463487032bb18318adea70
https://doi.org/10.1182/blood.v77.9.2059.2059

Vitamin C deficiency in patients with sickle cell anemia

Autor: Sheau-Lin Ho, Tsan Liu, DT Chiu, Elliott Vichinsky, Bertram H. Lubin

Publikováno v: The American journal of pediatric hematology/oncology. 12(3)

Because peroxidative damage to red cell membranes may contribute to the pathophysiology of sickle cell disease, deficiency of fat- and water-soluble antioxidants could be a determinant in the pathogenesis of this disease. We have previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100ec76431d2e1258cdec803576905b8
https://pubmed.ncbi.nlm.nih.gov/2240472

Enrichment of two glycosyl-phosphatidylinositol-anchored proteins, acetylcholinesterase and decay accelerating factor, in vesicles released from human red blood cells

Autor: CM Xu, Bertram H. Lubin, Frans A. Kuypers, DT Chiu, P Butikofer

Publikováno v: Blood. 74:1481-1485

Several proteins are attached to the cell membrane by a glycosyl- phosphatidylinositol (GPI) anchor. In this report, we show that during vesiculation of human RBCs in vitro, two of these proteins, acetylcholinesterase and decay accelerating factor, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbb1f20da81f658b00cb0d13d0aff3c
https://doi.org/10.1182/blood.v74.5.1481.1481

Spectrin oxidation correlates with membrane vesiculation in stored RBCs

Autor: Bertram H. Lubin, GM Wagner, JH Qju, RH Heath, DT Chiu

Publikováno v: Blood. 69(6)

An increase in spectrin oxidation in a variety of erythrocytes displaying a tendency to vesiculate has been previously described. To explore this relationship in more detail, we have studied blood stored in citrate-phosphate-dextrose-adenine under bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a44e54edaa09e877065a49ae4ea3df2
https://pubmed.ncbi.nlm.nih.gov/3580578

A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research.

Autor: Lee SY; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Klingeborn M; McLaughlin Research Institute, Great Falls, Montana, USA., Bulte JWM; Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Chiu DT; Department of Chemistry and Bioengineering, University of Washington, Seattle, Washington, USA., Chopp M; Department of Neurology, Henry Ford Health, Detroit, Michigan, USA., Cutler CW; Department of Periodontics, Dental College of Georgia at Augusta University, Georgia, USA., Das S; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Egwuagu CE; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA., Fowler CD; Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA., Hamm-Alvarez SF; Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Lee H; Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Liu Y; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA., Mead B; School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK., Moore TL; Department of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Ravindran S; Department of Oral Biology, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA., Shetty AK; Institute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University School of Medicine, College Station, Texas, USA., Skog J; Exosome Diagnostics, a Bio-Techne Brand, Waltham, Massachusetts, USA., Witwer KW; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Djalilian AR; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA., Weaver AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Publikováno v: Journal of extracellular vesicles [J Extracell Vesicles] 2024 Dec; Vol. 13 (12), pp. e70023.