Zobrazeno 1 - 10
of 1 075
pro vyhledávání: '"DSBs"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in ALS includes increased genomic damage and impaired DNA repair capability. The TAR-DNA bindin
Externí odkaz:
https://doaj.org/article/789bc818a5f940d18d10982b7e5cbe39
Autor:
Wessam Sharaf-Eldin
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Gene editing can produce irreversible permanent changes to the genetic material at predetermined sequences, avoiding random integration, which is the major drawback of classical gene therapy. The technology has invaded all approac
Externí odkaz:
https://doaj.org/article/c9a2a60c17cf456aa439262defeecb8c
Autor:
Saloua Kouass Sahbani
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 22, Iss 4, Pp 100425- (2024)
It is beyond doubt that radiotherapy is extremely effective in treating a wide variety of cancers. The sensitivity of the surrounding normal tissues limits the amount of radiation administered to the tumor. There is an urgent need to develop a treatm
Externí odkaz:
https://doaj.org/article/1ea95e0842f94ae1971f5d227e4dc26f
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Gene knock‐in refers to the insertion of exogenous functional genes into a target genome to achieve continuous expression. Currently, most knock‐in tools are based on site‐directed nucleases, which can induce double‐strand breaks (DS
Externí odkaz:
https://doaj.org/article/7137611656754d1eb9fd39fb8a7f60f0
Autor:
Shuaikang Chang, Wenqin Xiao, Yongsheng Xie, Zhijian Xu, Bo Li, Guanli Wang, Ke Hu, Yong Zhang, Jinfeng Zhou, Dongliang Song, Huabin Zhu, Xiaosong Wu, Yumeng Lu, Jumei Shi, Weiliang Zhu
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21321-21334 (2023)
AbstractBackgroundThyroid hormone receptor interacting protein 13 (Trip13) is an AAA‐ATPase that regulates the assembly or disassembly protein complexes and mediates Double‐strand breaks (DSBs) repair. Overexpression of Trip13 has been detected i
Externí odkaz:
https://doaj.org/article/accf8da71b9e458cb37793df8b9e98b3
Autor:
Vinay Jain, Divyalakshmi Saini, D. C. Soren, V. Anil Kumar, P. R. Vivek Kumar, P. K. M. Koya, G. Jaikrishan, Birajalaxmi Das
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-11 (2023)
Abstract Background The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 100 mGy. The level of r
Externí odkaz:
https://doaj.org/article/9fb4b7f971114e7da82de2649953b49c
Akademický článek
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Publikováno v:
Cells, Vol 12, Iss 20, p 2427 (2023)
Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness. Following high-LET IR, localized energy deposition along the particle trajector
Externí odkaz:
https://doaj.org/article/7028ccd34ec14529ac8410ef8b0e6441
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14956 (2023)
Radiation therapy is an essential component of present-day cancer management, utilizing ionizing radiation (IR) of different modalities to mitigate cancer progression. IR functions by generating ionizations in cells that induce a plethora of DNA lesi
Externí odkaz:
https://doaj.org/article/f11b8a94b0ab464fa5b00bdd9a148ffd
Autor:
Maria E. Stefanova, Elizabeth Ing-Simmons, Stefan Stefanov, Ilya Flyamer, Heathcliff Dorado Garcia, Robert Schöpflin, Anton G. Henssen, Juan M. Vaquerizas, Stefan Mundlos
Publikováno v:
Cells, Vol 12, Iss 15, p 2001 (2023)
In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin. Using Hi-C, ChIP-seq, and RNA-seq, we explore the changes in chromatin ar
Externí odkaz:
https://doaj.org/article/edab11f3c9e34c75851868cad695b089