Zobrazeno 1 - 1
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pro vyhledávání: '"DSB, double strand breakage"'
Autor:
Bhushan Thakur, Kazuho Ishine, Noriaki Shimizu, Mirit I. Aladjem, Ryonosuke Taniguchi, Koichi Utani
Publikováno v:
The Journal of Biological Chemistry
Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogen