Zobrazeno 1 - 10
of 6 249
pro vyhledávání: '"DRUG RESPONSE"'
Autor:
Wenbo Guo, Xinqi Li, Dongfang Wang, Nan Yan, Qifan Hu, Fan Yang, Xuegong Zhang, Jianhua Yao, Jin Gu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Understanding tumor cell heterogeneity and plasticity is crucial for overcoming drug resistance. Single-cell technologies enable analyzing cell states at a given condition, but catenating static cell snapshots to characterize dynamic drug re
Externí odkaz:
https://doaj.org/article/f237dbdab145472e972a2a617f8cdc36
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug response
Externí odkaz:
https://doaj.org/article/f1c9552d84e14eafa67c1b5380b0805d
Autor:
Stearns, Stephen C., author, Medzhitov, Ruslan, author
Publikováno v:
Evolutionary Medicine, 2024, ill.
Externí odkaz:
https://doi.org/10.1093/oso/9780192871978.003.0005
Publikováno v:
Journal of Integrative Bioinformatics, Vol 21, Iss 3, Pp 1093-8 (2024)
Drug therapy remains the primary approach to treating tumours. Variability among cancer patients, including variations in genomic profiles, often results in divergent therapeutic responses to analogous anti-cancer drug treatments within the same coho
Externí odkaz:
https://doaj.org/article/1641c9b3c5c34817b001ea2ca0b7a5cf
Autor:
Yen Thi My Nguyen, Bao-Quoc Vu, Duy-Khai Nguyen, Ngoc-Vinh Quach, Liem Thanh Bui, Jeonghan Hong, Chi-Bao Bui
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Neonatal intensive care unit (NICU), particularly in treating developmental and epileptic encephalopathy (DEE) and metabolic epilepsy (ME), requires a deep understanding of their complex etiologies and treatment responses. After excluding tr
Externí odkaz:
https://doaj.org/article/82f123a85d2440b7ba55d63af1b5887e
Autor:
Stefan Schmidt, Alexander Geisel, Thomas Enzlein, Björn C. Fröhlich, Louise Pritchett, Melanie Verneret, Christian Graf, Carsten Hopf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Potency assessment of monoclonal antibodies or corresponding biosimilars in cell-based assays is an essential prerequisite in biopharmaceutical research and development. However, cellular bioassays are still subject to limitations in sample
Externí odkaz:
https://doaj.org/article/4e15564bbbfa4cfeaf410123fd917c83
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Acute myeloid leukemia (AML) exhibits pronounced heterogeneity and chemotherapy resistance. Aberrant programmed cell death (PCD) implicated in AML pathogenesis suggests PCD-related signatures could serve as biomarkers to predict clinical out
Externí odkaz:
https://doaj.org/article/e79c72f0ad79490f88b5fa41f300991a
Publikováno v:
Onco, Vol 4, Iss 3, Pp 143-162 (2024)
As precision medicine such as targeted therapy and immunotherapy often have limited accessibility, low response rate, and evolved resistance, it is urgent to develop simple, low-cost, and quick-turnaround personalized diagnostic technologies for drug
Externí odkaz:
https://doaj.org/article/2de7fac8377548099f7b8e31f963a18b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Considering the key role of myeloid cell differentiation—related genes in the tumor microenvironment (TME), we aimed to build a prognostic risk model using these genes for Lung adenocarcinoma (LUAD). The mRNA gene expression profiles of LU
Externí odkaz:
https://doaj.org/article/430fa27589c14aeba0b57e9feafd9d9f
Publikováno v:
Translational Oncology, Vol 50, Iss , Pp 102117- (2024)
Regulated cell death (RCD) has been documented to have great potentials for discovering novel biomarkers and therapeutic targets in malignancies. But its role and clinical value in HR+/HER2- breast cancer, the most common subtype of breast cancer, ar
Externí odkaz:
https://doaj.org/article/1887899a572340eea3060f0d211e115f