Zobrazeno 1 - 10
of 3 931
pro vyhledávání: '"DRP1"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract This study investigated the role of mitochondrial dynamics in postoperative cognitive dysfunction (POCD) and assessed the therapeutic potential of mitochondrial modulation, particularly through the inhibition of dynamin-related protein 1 (DR
Externí odkaz:
https://doaj.org/article/4ba713ee0432430d9f6cad8f7bb11920
Autor:
Jiejie Zhang, Shan Wang, Haitao Zhang, Xiaotong Yang, Xin Ren, Lei Wang, Yihan Yang, Yi Yang, Ya Wen
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract The aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple diseases including neurodegenerative diseases and cerebral ischemic injury. Previous studies have shown that depletion of mitochondrial NAD+, whic
Externí odkaz:
https://doaj.org/article/51b25f8766ba48aaa422fc9672ae9deb
Autor:
Dongyao Hou, Ruixue Liu, Shuai Hao, Yong Dou, Guizhen Chen, Liangming Liu, Tao Li, Yunxing Cao, He Huang, Chenyang Duan
Publikováno v:
Pharmaceutical Biology, Vol 62, Iss 1, Pp 250-260 (2024)
AbstractContext Sepsis can result in critical organ failure, and notoginsenoside R1 (NGR1) offers mitochondrial protection.Objective To determine whether NGR1 improves organ function and prognosis after sepsis by protecting mitochondrial quality.Mate
Externí odkaz:
https://doaj.org/article/19166c5812f24bd089ae13a55298d8aa
Autor:
Yong Du, Jiaqing He, Yanni Xu, Xun Wu, Hongbo Cheng, Jiegang Yu, Xiaoliang Wang, Yaqing An, Yang Wu, Wei Guo
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Vascular dementia (VaD) is a prevalent form of dementia resulting from chronic cerebral hypoperfusion (CCH). However, the pathogenic mechanisms of VaD and corresponding therapeutic strategies are not well understood. Sirtuin 6 (SIRT6) has be
Externí odkaz:
https://doaj.org/article/668a3585517941d481c58d00047cc945
Autor:
Marvi Ghani, Bernadett Szabó, Mahmoud Alkhatibe, Hailemariam Amsalu, Peleg Zohar, Eszter Anna Janka, János András Mótyán, Krisztina Tar
Publikováno v:
FEBS Open Bio, Vol 14, Iss 7, Pp 1147-1165 (2024)
Continuous fusion and fission are critical for mitochondrial health. In this study, we further characterize the role played by dynamin‐related protein 1 (Drp1) in mitochondrial fission. We show that a single amino acid change in Drp1 at position 39
Externí odkaz:
https://doaj.org/article/19ffca4c0a7c41e2aa21802b52e4fb16
Autor:
Jingxia Du, Hongchao Li, Jingjing Song, Tingting Wang, Yibo Dong, An Zhan, Yan Li, Gaofeng Liang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/65930a01893249b1b9dae90a8eda31ab
Autor:
Yu Zhu, Lei Kuang, Yue Wu, Haoyue Deng, Han She, Yuanqun Zhou, Jie Zhang, Liangming Liu, Tao Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/39be276dba444cdb86ee53412ab49633
Autor:
Preethy S. Sridharan, Yeojung Koh, Emiko Miller, Di Hu, Suwarna Chakraborty, Sunil Jamuna Tripathi, Teresa R. Kee, Kalyani Chaubey, Edwin Vázquez-Rosa, Sarah Barker, Hui Liu, Rose A. León-Alvarado, Kathryn Franke, Coral J. Cintrón-Pérez, Matasha Dhar, Min-Kyoo Shin, Margaret E. Flanagan, Rudolph J. Castellani, Tamar Gefen, Marina Bykova, Lijun Dou, Feixiong Cheng, Brigid M. Wilson, Hisashi Fujioka, David E. Kang, Jung-A.A. Woo, Bindu D. Paul, Xin Qi, Andrew A. Pieper
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101715- (2024)
Summary: Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurodeg
Externí odkaz:
https://doaj.org/article/78517b6c384645a8be41713376606e5d
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung diseases, which mainly existed in middle-aged and elderly people. The accumulation of reactive oxygen species (ROS) is a common characteristic of IPF.
Externí odkaz:
https://doaj.org/article/2f47a8f47fe7410f96bd820fe5cdfee2
Autor:
Zhidi Lin, Guangyu Xu, Xiao Lu, Siyang Liu, Fei Zou, Xiaosheng Ma, Jianyuan Jiang, Hongli Wang, Jian Song
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Cartilaginous endplate (CEP) degeneration, which is an important contributor to intervertebral disc degeneration (IVDD), is characterized by chondrocyte death. Accumulating evidence has revealed that dynamin-related protein 1 (Drp
Externí odkaz:
https://doaj.org/article/d1485939aae5441c81f55a2e7a060de7