Zobrazeno 1 - 10
of 72
pro vyhledávání: '"DREAM Challenge"'
Autor:
Roger P. Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E. A. Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L. Van Nostrand, Emily LaPlante, Bogdan Mateescu, Brian S. White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M. Spengler
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of d
Externí odkaz:
https://doaj.org/article/d4209b9f34794e26b87ce77d73536889
Publikováno v:
BMC Genomics, Vol 20, Iss S13, Pp 1-8 (2019)
Abstract Background To infer gene regulatory networks (GRNs) from gene-expression data is still a fundamental and challenging problem in systems biology. Several existing algorithms formulate GRNs inference as a regression problem and obtain the netw
Externí odkaz:
https://doaj.org/article/b29208bbaa25414ba2ef192e67bebbd3
Akademický článek
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Autor:
Eugene F. Douglass, Robert J. Allaway, Bence Szalai, Wenyu Wang, Tingzhong Tian, Adrià Fernández-Torras, Ron Realubit, Charles Karan, Shuyu Zheng, Alberto Pessia, Ziaurrehman Tanoli, Mohieddin Jafari, Fangping Wan, Shuya Li, Yuanpeng Xiong, Miquel Duran-Frigola, Martino Bertoni, Pau Badia-i-Mompel, Lídia Mateo, Oriol Guitart-Pla, Verena Chung, Jing Tang, Jianyang Zeng, Patrick Aloy, Julio Saez-Rodriguez, Justin Guinney, Daniela S. Gerhard, Andrea Califano
Publikováno v:
Cell Reports Medicine
Summary The Columbia Cancer Target Discovery and Development (CTD2) Center is developing PANACEA, a resource comprising dose-responses and RNA sequencing (RNA-seq) profiles of 25 cell lines perturbed with ∼400 clinical oncology drugs, to study a tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d40d6404b3339a2d521e9a33b55fc64
http://europepmc.org/articles/PMC8784774
http://europepmc.org/articles/PMC8784774
Autor:
Minji Jeon, Justin Guinney, Zhaoping Xiong, Donghyeon Park, Jinhyuk Lee, Robert J. Allaway, Heather A. Carlson, Ruben Abagyan, Tirtha K. Das, Chana Hecht, Hwisang Jeon, Xindi Guo, Miyoung Ko, Aik Choon Tan, Alexander Tropsha, Jaewoo Kang, Multi-Targeting Drug Dream Challenge Community, Ross L. Cagan, Kristen K. Dang, Mingyue Zheng, Hualiang Jiang, Avner Schlessinger
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009302 (2021)
PLoS computational biology, vol 17, iss 9
PLoS Computational Biology
PLoS computational biology, vol 17, iss 9
PLoS Computational Biology
A continuing challenge in modern medicine is the identification of safer and more efficacious drugs. Precision therapeutics, which have one molecular target, have been long promised to be safer and more effective than traditional therapies. This appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a46796ee0a1cbcc1a192e14e0abf555
https://doaj.org/article/760d14f1687d40cc99f25eb1a90cecb7
https://doaj.org/article/760d14f1687d40cc99f25eb1a90cecb7
Autor:
Creason, Allison, Haan, David, Dang, Kristen, Chiotti, Kami E, Inkman, Matthew, Lamb, Andrew, Yu, Thomas, Hu, Yin, Norman, Thea C, Buchanan, Alex, van Baren, Marijke J, Spangler, Ryan, Rollins, M Rick, Spellman, Paul T, Rozanov, Dmitri, Zhang, Jin, Maher, Christopher A, Caloian, Cristian, Watson, John D, Uhrig, Sebastian, Haas, Brian J, Jain, Miten, Akeson, Mark, Ahsen, Mehmet Eren, SMC-RNA Challenge Participants, Stolovitzky, Gustavo, Guinney, Justin, Boutros, Paul C, Stuart, Joshua M, Ellrott, Kyle
Publikováno v:
Cell systems, vol 12, iss 8
The accurate identification and quantitation of RNA isoforms present in the cancer transcriptome is key for analyses ranging from the inference of the impacts of somatic variants to pathway analysis to biomarker development and subtype discovery. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::f35994f11622f6f02f1577c3e32233cc
https://escholarship.org/uc/item/2g61t5rp
https://escholarship.org/uc/item/2g61t5rp
Publikováno v:
Genes
Volume 12
Issue 1
Genes, Vol 12, Iss 28, p 28 (2021)
Volume 12
Issue 1
Genes, Vol 12, Iss 28, p 28 (2021)
Single-cell transcriptomics data, when combined with in situ hybridization patterns of specific genes, can help in recovering the spatial information lost during cell isolation. Dialogue for Reverse Engineering Assessments and Methods (DREAM) consort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aca3aa420eded656072cc485ea1df0
Publikováno v:
Genes
Single-cell transcriptomics data, when combined with in situ hybridization patterns of specific genes, can help in recovering the spatial information lost during cell isolation. Dialogue for Reverse Engineering Assessments and Methods (DREAM) consort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::006791038c30feb15b4421403ce0ae44
https://pubmed.ncbi.nlm.nih.gov/33379262
https://pubmed.ncbi.nlm.nih.gov/33379262
Autor:
Didier Barradas-Bautista
In several countries, vector-borne diseases play a significant role in the burden of public and individual health. Mosquitoes transmit diseases such as dengue and malaria. Malaria is a disease caused by Plasmodium parasites and transmitted by Anophel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afca5af9935d606eae7bcadbae3dd3c
Publikováno v:
Briefings in bioinformatics. 22(3)
Motivation Predicting cell locations is important since with the understanding of cell locations, we may estimate the function of cells and their integration with the spatial environment. Thus, the DREAM challenge on single-cell transcriptomics requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b76ca972b662fc4a9b3374d222563
https://pubmed.ncbi.nlm.nih.gov/34020545
https://pubmed.ncbi.nlm.nih.gov/34020545