Zobrazeno 1 - 10
of 1 058
pro vyhledávání: '"DREADD"'
Autor:
Takashi Ogino, Masakazu Agetsuma, Masato Sawada, Hiroyuki Inada, Junichi Nabekura, Kazunobu Sawamoto
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Activation of astrocytes after sensory stimulation has been reported to be involved in increased blood flow in the central nervous system. In the present study, using a chemogenetic method to induce astrocyte activation in mice without senso
Externí odkaz:
https://doaj.org/article/edf68c905da0412eb5d3fec4c29f1626
Autor:
Péter Kovács, Tamás Kitka, Zsolt Kristóf Bali, Lili Veronika Nagy, Angelika Bodó, Tamás Kovács-Öller, Zalán Péterfi, István Hernádi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Despite the therapeutic potential of chemogenetics, the method lacks comprehensive preclinical validation, hindering its progression to human clinical trials. We aimed to validate a robust but simple in vivo efficacy assay in rats which coul
Externí odkaz:
https://doaj.org/article/bd005964240140cb83a7ae67e9cafe0a
Publikováno v:
Spine Surgery and Related Research, Vol 8, Iss 1, Pp 22-28 (2024)
Spinal cord injury (SCI) is a devastating injury that causes permanent neurological dysfunction. To develop a new treatment strategy for SCI, a clinical trial of transplantation of human-induced pluripotent stem cell-derived neural precursor cells (N
Externí odkaz:
https://doaj.org/article/c0f8ccb63a7e425cab8b8aa69dc4bd53
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionChemogenetic techniques, specifically the use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), have become invaluable tools in neuroscience research. Yet, the understanding of how Gq- and Gicoupled DREADDs alter lo
Externí odkaz:
https://doaj.org/article/27938d2f02cd459bb30ec188cb51e0ff
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8849 (2024)
In patients with Parkinson’s disease (PD), dopamine replacement therapy with dopamine D2/D3 receptor agonists induces impairments in decision-making, including pathological gambling. The neurobiological mechanisms underlying these adverse effects r
Externí odkaz:
https://doaj.org/article/56308d376df84d89b31f6e7fc7586423
Autor:
Christina A. Watts, Jordan Smith, Roman Giacomino, Dinah Walter, Guensu Jang, Aalia Malik, Nicholas Harvey, Colleen M. Novak
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 821 (2024)
Allostatic adaptations to a perceived threat are crucial for survival and may tap into mechanisms serving the homeostatic control of energy balance. We previously established that exposure to predator odor (PO) in rats significantly increases skeleta
Externí odkaz:
https://doaj.org/article/3601de279b5247489339ef52f07bdcaf
Autor:
Ning Zheng, Zhu Gui, Xiaodong Liu, Yang Wu, Huadong Wang, Aoling Cai, Jinfeng Wu, Xihai Li, Challika Kaewborisuth, Zhijian Zhang, Qitian Wang, Anne Manyande, Fuqiang Xu, Jie Wang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background The ventral tegmental area (VTA) contains heterogeneous cell populations. The dopaminergic neurons in VTA play a central role in reward and cognition, while CamKIIα-positive neurons, composed mainly of glutamatergic and some dopa
Externí odkaz:
https://doaj.org/article/10e97f2b2e274cd989563f8622322535
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
Previous work has demonstrated the importance of the prelimbic cortex (PL) in contextual control of operant behavior. However, the associated neural circuitry responsible for providing contextual information to the PL is not well understood. In Pavlo
Externí odkaz:
https://doaj.org/article/af74bed7735548bd854538f16d21449c
Autor:
Lillian Yang, John H. Martin
Publikováno v:
Brain Stimulation, Vol 16, Iss 3, Pp 759-771 (2023)
Background: Neural activity helps construct neural circuits during development and this function is leveraged by neuromodulation protocols to promote connectivity and repair in maturity. Neuromodulation targeting the motor cortex (MCX) strengthens co
Externí odkaz:
https://doaj.org/article/70354b55ad2548019b09b1fc7b797f0b
Publikováno v:
Bioengineering, Vol 11, Iss 5, p 487 (2024)
Cell therapy has proven to be a promising treatment for a range of neurological disorders, including Parkinson Disease, drug-resistant epilepsy, and stroke, by restoring function after brain damage. Nevertheless, evaluating the true effectiveness of
Externí odkaz:
https://doaj.org/article/8112c9383e244494b338f8b32692b547