Binding of C4b-binding protein to porin: A molecular mechanism of serum resistance of Neisseria gonorrhoeae

Autor: S Ram, Meabh Cullinane, AM Blom, S Gulati, DP McQuillen, BG Monks, C O'Connell, R Boden, C Elkins, MK Pangburn, B Dahlbäck, PA Rice

We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp). Microbial surface-bound C4bp demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bdc8f77b6486be5b959363a15489ed7

Nirmatrelvir-Ritonavir for Acute COVID-19 in Patients With Cardiovascular Disease and Postacute Sequelae of SARS-CoV-2 Infection.

Autor: Patel R; Department of Internal Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Dani SS; Department of Cardiovascular Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Khadke S; Department of Cardiovascular Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Kumar A; Department of Internal Medicine, Cleveland Clinic Akron General, Akron, Ohio, USA., Ahmad J; Department of Cardiovascular Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Saji AM; Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA., Shah J; Department of Internal Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Mehta N; Department of Internal Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Wener K; Department of Infectious Diseases, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., McQuillen DP; Department of Infectious Diseases, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Abraham G; Division of Infectious Disease, Department of Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA., Faust J; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Maley J; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Patel S; Department of Psychiatry, Lahey Hospital and Medical Centre, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Mullington J; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Wachter RM; Department of Medicine, University of California-San Francisco, San Francisco, California, USA., Mosenthal A; Department of Academic Affairs, Lahey Hospital and Medical Center, Tufts University School of Medicine, Burlington, Massachusetts, USA., Sax PE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Ganatra S; Department of Cardiovascular Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA.

Publikováno v: JACC. Advances [JACC Adv] 2024 Jun 26; Vol. 3 (6), pp. 100961. Date of Electronic Publication: 2024 Jun 26 (Print Publication: 2024).

Oral Nirmatrelvir and Ritonavir in Nonhospitalized Vaccinated Patients With Coronavirus Disease 2019.

Autor: Ganatra S; Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Dani SS; Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Ahmad J; Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Kumar A; Department of Medicine, Cleveland Clinic Akron General, Akron, Ohio, USA., Shah J; Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Abraham GM; Division of Infectious Disease, Department of Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA., McQuillen DP; Division of Infectious Disease, Department of Medicine, Lahey Hospital and Medical Center, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Wachter RM; Department of Medicine, University of California San Francisco, San Francisco, California, USA., Sax PE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Feb 18; Vol. 76 (4), pp. 563-572.

Reply.

Autor: Aronsohn AI; Center for Liver DiseasesUniversity of Chicago Medical CenterChicagoIllinoisUSA., Bhattacharya D; Division of Infectious DiseasesUniversity of California Los AngelesLos AngelesCaliforniaUSA., Morgan TR; Department of MedicineVeterans Affairs Long Beach Healthcare SystemLong BeachCaliforniaUSA., Wyles DL; Division of Infectious DiseasesDenver Health Medical CenterDenverColoradoUSA., Chung RT; Liver CenterMassachusetts General HospitalBostonMassachusettsUSA., McQuillen DP; Division of Infectious DiseasesBeth Israel Lahey Health - Lahey Hospital & Medical CenterBurlingtonMassachusettsUSA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2022 Apr; Vol. 75 (4), pp. 1055-1056. Date of Electronic Publication: 2021 Dec 19.

Jamestown Canyon virus in Massachusetts: clinical case series and vector screening.

Autor: Kinsella CM; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA., Paras ML; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Smole S; Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Jamaica Plain, MA, USA., Mehta S; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA., Ganesh V; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Chen LH; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of Infectious Diseases and Travel Medicine, Beth Israel Lahey Health, Mount Auburn Hospital, Cambridge, MA, USA., McQuillen DP; Department of Infectious Disease, Beth Israel Lahey Health, Lahey Hospital and Medical Center, Burlington, MA, USA.; Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts University School of Medicine, Boston, MA, USA., Shah R; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of Infectious Diseases, North Shore Medical Center, Salem, MA, USA., Chan J; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Osborne M; Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Jamaica Plain, MA, USA., Hennigan S; Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Jamaica Plain, MA, USA., Halpern-Smith F; Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Jamaica Plain, MA, USA., Brown CM; Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Jamaica Plain, MA, USA., Sabeti P; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Piantadosi A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 903-912.