Zobrazeno 1 - 10
of 110
pro vyhledávání: '"DORIS A. STOFFERS"'
Autor:
Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, Wei Qin, Daniel Traum, Long Gao, Jinping Liu, Elisabetta Manduchi, Chengyang Liu, Maria L. Golson, Golnaz Vahedi, Ali Naji, Franz M. Matschinsky, Mark A. Atkinson, Alvin C. Powers, Marcela Brissova, Klaus H. Kaestner, Doris A. Stoffers, for the HPAP Consortium
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only approximately 15% of individuals who are positive for single AAbs (generally against
Externí odkaz:
https://doaj.org/article/ed4642c42951458c9cba96f40f54dcec
Autor:
John S. Kaddis, Layla Rouse, Audrey V. Parent, Diane C. Saunders, Anath Shalev, Cherie L. Stabler, Doris A. Stoffers, Bridget K. Wagner, Joyce C. Niland
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101283- (2021)
Externí odkaz:
https://doaj.org/article/4b11df8c757349c58bcb1ec2250baff0
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 45-56 (2019)
Objective: Pancreatic β cell failure plays a central role in the development of type 2 diabetes (T2D). While the transcription factors shaping the β cell gene expression program have received much attention, the post-transcriptional controls that a
Externí odkaz:
https://doaj.org/article/92feb68a50ff450dbea3acb1c59b44a1
Autor:
Austin L. Good, Corey E. Cannon, Matthew W. Haemmerle, Juxiang Yang, Diana E. Stanescu, Nicolai M. Doliba, Morris J. Birnbaum, Doris A. Stoffers
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 95-106 (2019)
Objective: In type 2 diabetes (T2D), oxidative stress contributes to the dysfunction and loss of pancreatic β cells. A highly conserved feature of the cellular response to stress is the regulation of mRNA translation; however, the genes regulated at
Externí odkaz:
https://doaj.org/article/49f72e95647f4aa0be1c4d9996d87bb3
Autor:
Christine A. Juliana, Juxiang Yang, Corey E. Cannon, Austin L. Good, Matthew W. Haemmerle, Doris A. Stoffers
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 39-48 (2018)
Objective: Loss of insulin secretion due to failure or death of the insulin secreting β cells is the central cause of diabetes. The cellular response to stress (endoplasmic reticulum (ER), oxidative, inflammatory) is essential to sustain normal β c
Externí odkaz:
https://doaj.org/article/d2ff88f04baf491bb40d3e4ce3046733
Autor:
Andrea V. Rozo, Daniella A. Babu, PoMan A. Suen, David N. Groff, Randy J. Seeley, Rebecca A. Simmons, Patrick Seale, Rexford S. Ahima, Doris A. Stoffers
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 748-759 (2017)
Objective: Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonata
Externí odkaz:
https://doaj.org/article/6a6b1ca3710442509401cd64c29481e1
Autor:
Jarrett R. Remsberg, Benjamin N. Ediger, Wesley Y. Ho, Manashree Damle, Zhenghui Li, Christopher Teng, Cristina Lanzillotta, Doris A. Stoffers, Mitchell A. Lazar
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 30-37 (2017)
Objective: Histone deacetylases are epigenetic regulators known to control gene transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has been shown to regulate metabolic genes. Cell culture studies with HDAC-speci
Externí odkaz:
https://doaj.org/article/7622bc83837c4cea8b08ed6fec306d53
Autor:
Kathryn D. Henley, Diana E. Stanescu, Peter A. Kropp, Christopher V.E. Wright, Kyoung-Jae Won, Doris A. Stoffers, Maureen Gannon
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2637-2650 (2016)
Pdx1 and Oc1 are co-expressed in multipotent pancreatic progenitors and regulate the pro-endocrine gene Neurog3. Their expression diverges in later organogenesis, with Oc1 absent from hormone+ cells and Pdx1 maintained in mature β cells. In a classi
Externí odkaz:
https://doaj.org/article/cc543e4b56534decb276fea49db47146
Autor:
Corey E. Cannon, Paul M. Titchenell, David N. Groff, Abdelfattah El Ouaamari, Rohit N. Kulkarni, Morris J. Birnbaum, Doris A. Stoffers
Publikováno v:
Molecular Metabolism, Vol 3, Iss 8, Pp 794-802 (2014)
Objective: The Polycomb Repressive Complexes (PRC) 1 and 2 function to epigenetically repress target genes. The PRC1 component, Bmi1, plays a crucial role in maintenance of glucose homeostasis and beta cell mass through repression of the Ink4a/Arf lo
Externí odkaz:
https://doaj.org/article/cdfb51741d2846dabdebdf255f1ab73f
Autor:
Maureen Gannon, Alexis U. Oguh, Xiaogdong Zhu, Morgan A. Gingerich, Doris A. Stoffers, Scott A. Soleimanpour
Publikováno v:
Diabetes
Current evidence indicates that proliferating β-cells express lower levels of some functional cell identity genes, suggesting that proliferating cells are not optimally functional. Pdx1 is important for β-cell specification, function, and prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e76a2dc96aab428252ea5d27edfbda3
https://doi.org/10.2337/db20-0599
https://doi.org/10.2337/db20-0599