Zobrazeno 1 - 10
of 31
pro vyhledávání: '"DONNA M. GAUVIN"'
Autor:
Donna M. Gauvin, C.Z. Zhu, Rueter Le, Charles D. Mills, Lewis Lg, C.-H. Lee, Decker Mw, A.W. Bannon, C. Zhong, Hsieh Gc, Joshi Sk, Joseph P. Mikusa
Publikováno v:
European Journal of Pain. 16:816-826
Background Most animal models currently used to evaluate antinociceptive efficacy of analgesics rely on the assessment of evoked pain behaviours as primary endpoints. Mehtods Here, we have developed and characterized the carrageenaninduced locomotor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22c202f77f0444c57d5bb915a60d8ce
https://doi.org/10.1002/j.1532-2149.2011.00099.x
https://doi.org/10.1002/j.1532-2149.2011.00099.x
Autor:
Chih-Hung Lee, Ann Tovcimak, Michael W. Decker, Gerard B. Fox, Gricelda H. Simler, Prisca Honore, Jordan W. Brown, Chang Z. Zhu, Madhavi Pai, Nathan R. Rustay, Chih-Liang Chin, Chengmin Zhong, Joe Mikusa, Murali Gopalakrishnan, Victoria A. Komater, Donna M. Gauvin, Anita K. Salyers, Scott J. Baker, La Geisha Lewis, Peer B. Jacobson, Erica Gomez, Prasant Chandran
Publikováno v:
Biochemical Pharmacology. 82:967-976
Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) α4β2 subtype by selective positive allosteric modulator NS-9283 has shown to potentiate the nAChR agonist ABT-594-induced anti-allodynic activity in preclinical neuropathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1340266ffc68c882923bbd524daa5706
https://doi.org/10.1016/j.bcp.2011.05.007
https://doi.org/10.1016/j.bcp.2011.05.007
Autor:
Jerome F. Daanen, Joseph P. Mikusa, Chih Hung Lee, Chengmin Zhong, Jason A. Segreti, Patrick W. Mantyh, Torben R. Neelands, Patricia N. Banfor, Michael F. Jarvis, Arthur Gomtsyan, Prasant Chandran, Molly A. Sevcik, Philip R. Kym, Donna M. Gauvin, Regina M. Reilly, Kennan C. Marsh, Michael E. Kort, Connie R. Faltynek, James P. Sullivan, Erol K. Bayburt, Carol S. Surowy, Joseph R. Ghilardi, Prisca Honore, Gricelda Hernandez, Ryan M. Fryer, Shailen K. Joshi
Publikováno v:
Pain. 142:27-35
Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. TRPV1 antagonists have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26cec77f1eb7a5454a08a328e395101
https://doi.org/10.1016/j.pain.2008.11.004
https://doi.org/10.1016/j.pain.2008.11.004
Autor:
Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6379-6386
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003
https://doi.org/10.1016/j.bmc.2008.05.003
Autor:
Chang Z. Zhu, Peter R. Hollingsworth, Donna M. Gauvin, Sonya G. Lehto, Renjie Chang, Prisca Honore, Jorge D. Brioni, Scott J. Baker, Gricelda Hernandez, GuoZhu Zheng, Robert B. Moreland, Odile EI-Kouhen, Andrew O. Stewart
Publikováno v:
European Journal of Pharmacology. 580:314-321
Activation of metabotropic glutamate (mGlu) receptors has previously been shown to play a role in inflammatory or neuropathic pain states. However, the role of mGlu type 1 receptors in post-operative pain remains to be investigated. In the present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc7c4bfb04efdede560e59d69f8a707
https://doi.org/10.1016/j.ejphar.2007.09.047
https://doi.org/10.1016/j.ejphar.2007.09.047
Autor:
Ann Tovcimak, Gin C. Hsieh, Madhavi Pai, Bryan F. Cox, Chih-Liang Chin, Jennifer M. Frost, B B Yao, Michael Meyer, PR Hollingsworth, Donna M. Gauvin, Gerard B. Fox, Prasant Chandran, Chang Z. Zhu, Prisca Honore, T. R. Seifert, Vincent P. Hradil, Jill M. Wetter, Michael J. Dart
Publikováno v:
British Journal of Pharmacology. 153:367-379
Background and purpose: Activation of cannabinoid CB1 and/or CB2 receptors mediates analgesic effects across a broad spectrum of preclinical pain models. Selective activation of CB2 receptors may produce analgesia without the undesirable psychotropic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5551858c313251bee592c203cf440f3
https://doi.org/10.1038/sj.bjp.0707506
https://doi.org/10.1038/sj.bjp.0707506
Autor:
Stevan W. Djuric, Kennan C. Marsh, Gin C. Hsieh, Michael P. Sheets, Yung-Wu Chen, Thomas A. Fey, Cindy Henry, Karl W. Mollison, Rolf Wagner, Donna M. Gauvin, George W. Carter, James M. Trevillyan, Teresa A. Rosenberg, Sandra E. Burke, Steve J. Ballaron, Joy Bauch, Morey L. Smith
Publikováno v:
Journal of Cardiovascular Pharmacology. 49:228-235
Sirolimus (rapamycin) is an immunosuppressant used in preventing allograft rejection and in drug-eluting stents to prevent restenosis after angioplasty. Zotarolimus, an analogue of sirolimus, was designed to have a shorter in vivo half-life. Zotaroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d70a94a47632b4c29594455a56393e
https://doi.org/10.1097/fjc.0b013e3180325b0a
https://doi.org/10.1097/fjc.0b013e3180325b0a
Autor:
Torben R. Neelands, C. Zhong, Erol K. Bayburt, B. Brown, Prisca Honore, Joseph P. Mikusa, W. Niforatos, Donna M. Gauvin, Gricelda Hernandez, H. McDonald, Michael W. Decker, Robert B. Moreland, Arthur Gomtsyan, Kennan C. Marsh, B. Bianchi, Prasant Chandran, Connie R. Faltynek, James P. Sullivan, C.-H. Lee, M. Cui
Publikováno v:
The Journal of Neuroscience. 26:9385-9393
Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0d962b3ad79f4a5ab44823bdc3504b
https://doi.org/10.1523/jneurosci.1246-06.2006
https://doi.org/10.1523/jneurosci.1246-06.2006
Autor:
Chengmin Zhong, Donna M. Gauvin, Arthur Gomtsyan, Prisca Honore, Connie R. Faltynek, James P. Sullivan, Rachid El Kouhen, Chang Z. Zhu, Joseph P. Mikusa, Michael F. Jarvis, Kennan C. Marsh, Carol T. Wismer, Chih-Hung Lee
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 314:410-421
The vanilloid receptor 1 (VR1, TRPV1), which is a member of the transient receptor potential (TRP) superfamily, is highly localized on peripheral and central processes of nociceptive afferent fibers. Activation of TRPV1 contributes to the pronocicept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affd3cda504e65a6c1a78c5991284d84
https://doi.org/10.1124/jpet.105.083915
https://doi.org/10.1124/jpet.105.083915
Autor:
Prisca Honore, Joseph P. Mikusa, Donna M. Gauvin, Michael W. Decker, Chang Z. Zhu, Sonya G. Wilson, Carol T. Wismer, Carrie L. Wade, James J. Lynch
Publikováno v:
European Journal of Pharmacology. 506:107-118
Preclinical data, performed in a limited number of pain models, suggest that functional blockade of metabotropic glutamate (mGlu) receptors may be beneficial for pain management. In the present study, effects of 2-methyl-6-(phenylethynyl)-pyridine (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b5b7e524f665038ffd57396dfa2620
https://doi.org/10.1016/j.ejphar.2004.11.005
https://doi.org/10.1016/j.ejphar.2004.11.005