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Akademický článek

Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement

Autor: Emily J. Koubek, Lorraine C. Santy

Publikováno v: Cells, Vol 11, Iss 22, p 3565 (2022)

Dock1, originally Dock180, was the first identified member of the Dock family of GTPase Exchange Factors. Early biochemical and genetic studies of Dock180 elucidated the functions and regulation of Dock180 and informed our understanding of all Dock f

Externí odkaz: https://doaj.org/article/d5cf28959a0e427480f320ed70d30502

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Akademický článek

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Akademický článek

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Akademický článek

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Akademický článek

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Signaling adaptor protein Crk is involved in malignant feature of pancreatic cancer associated with phosphorylation of c-Met

Autor: Jun Suzuka, Lei Wang, Masumi Tsuda, Shinya Tanaka, Hirokazu Sugino, Satoko Uemura, Satoshi Tanikawa, Satoshi Hirano, Toru Nakamura, Tomoko Mitsuhashi

Publikováno v: Biochemical and Biophysical Research Communications. 524:378-384

Signaling adaptor protein Crk has been shown to play an important role in various human cancers. Crk links tyrosine kinases and guanine nucleotide exchange factors (GEFs) such as C3G and Dock180 to activate small G-proteins Rap and Rac, respectively.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8c001289f5b3919a5967b4ec73192a
https://doi.org/10.1016/j.bbrc.2020.01.105

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ELMO1 signaling is a promoter of osteoclast function and bone loss

Autor: Laura S. Shankman, Ming-Ming Zhou, Kodi S. Ravichandran, Scott F. Walk, Sanja Arandjelovic, Dirk Elewaut, Adam Ceroi, Thomas P. Conrads, Igor Smirnov, Isabelle Cambré, Suna Onengut-Gumuscu, Justin S. A. Perry

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
NATURE COMMUNICATIONS

Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone loss. Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in osteoclasts. We note that ELMO1 SNPs associate with bone abnormalitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce83cac9e6f2548d521dea180ef3572
http://europepmc.org/articles/PMC8371122

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ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1

Autor: Wen Li, Wai Wa Ray Chan, Raymond Chuen-Chung Chang, Kwok-Fai Lau

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(12)

Ras-related C3 botulinum toxin substrate 1 (Rac1) is a member of the Rho family of GTPases that functions as a molecular switch to regulate many important cellular events including actin cytoskeleton remodeling during neurite outgrowth. Engulfment an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a113cb998a465d5102eb6368043fdfef
https://pubmed.ncbi.nlm.nih.gov/33047393

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Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1

Autor: Ho Yin Edwin Chan, Jacky Chi Ki Ngo, Kwok-Fai Lau, Wai Wan Ray Chan, Alex Chun Koon, Ka Ming Vincent Tam, Wen Li

Publikováno v: Journal of Biological Chemistry. 293:7674-7688

Neurite outgrowth is a crucial process in developing neurons for neural network formation. Understanding the regulatory mechanisms of neurite outgrowth is essential for developing strategies to stimulate neurite regeneration after nerve injury and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e7810f8029eb064ba85684a67551aa
https://doi.org/10.1074/jbc.ra117.000505

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Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1

Autor: Wai Wa Ray Chan, Kwok-Fai Lau, Wen Li, Dik Long Dennis Chau

Publikováno v: Bio Protoc

Intramolecular interaction is a common mechanism that regulates protein activities. Conventionally, such interactions are investigated by classical in vitro biochemical assays. Here, we describe a protocol for studying the intramolecular interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044602bafb4cc77bbccff74f8c34fc54
https://doi.org/10.21769/bioprotoc.3449

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