Zobrazeno 1 - 10
of 129
pro vyhledávání: '"DNMTi"'
Publikováno v:
Diseases, Vol 12, Iss 7, p 163 (2024)
Background: Ten-eleven-translocation (TET) 2 is a member of the TET family of proteins (TET1-3). DNMT1 gene deletion confers resistance to DNA methyltransferase (DNMT) inhibitors in colorectal, breast, and ovarian cancer cells. Currently, the effect
Externí odkaz:
https://doaj.org/article/e14f5360823048fb8a95a0df85fa0113
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1041 (2024)
Testicular germ cell tumors (TGCTs) are the most common type of testicular cancer, with a particularly high incidence in the 15–45-year age category. Although highly treatable, resistance to therapy sometimes occurs, with devastating consequences f
Externí odkaz:
https://doaj.org/article/976862fe91654da5a9cd77651be8432c
Autor:
Alain Chebly, Joana Ropio, Jean‐Marie Peloponese, Sandrine Poglio, Martina Prochazkova‐Carlotti, Floriane Cherrier, Jacky Ferrer, Yamina Idrissi, Evelyne Segal‐Bendirdjian, Eliane Chouery, Chantal Farra, Anne Pham‐Ledard, Marie Beylot‐Barry, Jean‐Philippe Merlio, Roland Tomb, Edith Chevret
Publikováno v:
Molecular Oncology, Vol 16, Iss 9, Pp 1931-1946 (2022)
Cutaneous T‐cell lymphomas (CTCLs) are telomerase‐positive tumors expressing hTERT, although neither gene rearrangement/amplification nor promoter hotspot mutations could explain the hTERT re‐expression. As the hTERT promoter is rich in CpG, we
Externí odkaz:
https://doaj.org/article/819e3dd1237742258055914e28ab5f6e
Akademický článek
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Autor:
Catharina Muylaert, Lien Ann Van Hemelrijck, Anke Maes, Kim De Veirman, Eline Menu, Karin Vanderkerken, Elke De Bruyne
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Drug resistance (DR) of cancer cells leading to relapse is a huge problem nowadays to achieve long-lasting cures for cancer patients. This also holds true for the incurable hematological malignancy multiple myeloma (MM), which is characterized by the
Externí odkaz:
https://doaj.org/article/aa9ed1f467844905aa29fbd891cea6e2
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7235 (2023)
Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer development and progression, and epigenetic-targeting drugs such a
Externí odkaz:
https://doaj.org/article/57a35c6a7bed4e25858e30658fef0308
Autor:
Mikhlid H. Almutairi, Turki M. Alrubie, Bader O. Almutairi, Abdullah M. Alamri, Abdulwahed F. Alrefaei, Maha M. Arafah, Mohammad Alanazi, Abdelhabib Semlali
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1319 (2022)
Background: The expression of human germline genes is restricted to the germ cells of the gonads, which produce sperm and eggs. The germline genes involved in testis development and potentially activated in cancer cells are known as cancer-testis (CT
Externí odkaz:
https://doaj.org/article/8d0a5153a937437daf3c616f62706f14
Anti-leukemic activity of DNA methyltransferase inhibitor procaine targeted on human leukaemia cells
Publikováno v:
Open Life Sciences, Vol 11, Iss 1, Pp 322-330 (2016)
Chromatin remodeling in DNA is fundamental to gene expression, DNA replication and repair processes. Methylation of promoter regions of tumor-suppressor genes and histone deacetylation leads to gene silencing and transcriptionally repressive chromati
Externí odkaz:
https://doaj.org/article/8e8871789d784af19c225cc5d1d163ae
Autor:
Fabio Coppedè
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:283-298
Introduction: Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly. Changes in DNA methylation and post-translational modifications...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98589e21eeff12c31e69a954070b4897
https://doi.org/10.1080/14728222.2021.1916469
https://doi.org/10.1080/14728222.2021.1916469
Akademický článek
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