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of 1 611
pro vyhledávání: '"DNA-PK"'
Publikováno v:
Data in Brief, Vol 53, Iss , Pp 110183- (2024)
DNA-dependent protein kinase catalytic subunit (DNA-PK) is a multifunctional serine‑threonine protein kinase that plays roles in non-homologous end joining of DNA repair in cells. NU7441 is a specific DNA-PKcs inhibitor. We investigated the effects
Externí odkaz:
https://doaj.org/article/fbd7c3424caf478ab4917769f90a8576
Akademický článek
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Publikováno v:
Thoracic Cancer, Vol 14, Iss 22, Pp 2127-2138 (2023)
Abstract Background Although radiotherapy has improved local control in esophageal squamous cell carcinoma (ESCC), a considerable number of patients still experience relapse due to resistance. In this study, we aimed to evaluate the effects of cetuxi
Externí odkaz:
https://doaj.org/article/bd14c78de3e94508a9853ee15cdb9003
Publikováno v:
Cancer Medicine, Vol 12, Iss 5, Pp 5939-5952 (2023)
Abstract Background DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor trea
Externí odkaz:
https://doaj.org/article/25cc38adda5c4f6f877cf851d228bac1
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5629 (2024)
(1) Head and neck squamous cell carcinoma (HNSCC) is common, while treatment is difficult, and mortality is high. Kinase inhibitors are promising to enhance the effects of radiotherapy. We compared the effects of the PARP inhibitors talazoparib and n
Externí odkaz:
https://doaj.org/article/f759a208ea7743f682c5b679efc11488
Autor:
Steffie Revia, Felix Neumann, Julia Jabs, Florian Orio, Christian Sirrenberg, Astrid Zimmermann, Christiane Amendt, Joachim Albers
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5120 (2024)
Triple-negative breast cancer (TNBC) remains the most lethal subtype of breast cancer, characterized by poor response rates to current chemotherapies and a lack of additional effective treatment options. While approximately 30% of patients respond we
Externí odkaz:
https://doaj.org/article/8f3b1449f0f54b269940a3f1398efdd0
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Double‐strand break (DSB), a significant DNA damage brought on by ionizing radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The two primary pathways for DNA DSB repair in mammalian cells are nonhom
Externí odkaz:
https://doaj.org/article/3eeaff1b6f974f4d87633f5c1f63752a
Autor:
Mary Smithson, Regina K. Irwin, Gregory Williams, M. Chandler McLeod, E. Karen Choi, Anutosh Ganguly, Ashley Pepple, Clifford S. Cho, Christopher D. Willey, Judith Leopold, Karin M. Hardiman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 25, Iss , Pp 53-61 (2022)
Treatment of locally advanced rectal cancer includes chemoradiation and surgery, but patient response to treatment is variable. Patients who have a complete response have improved outcomes; therefore, there is a critical need to identify mechanisms o
Externí odkaz:
https://doaj.org/article/e7127184d1b943bc8a3472e24ba7c525
Autor:
Nina Klieber, Laura S. Hildebrand, Eva Faulhaber, Julia Symank, Nicole Häck, Annamaria Härtl, Rainer Fietkau, Luitpold V. Distel
Publikováno v:
Cells, Vol 13, Iss 4, p 304 (2024)
Despite substantial advancements in understanding the pathomechanisms of head and neck squamous cell carcinoma (HNSCC), effective therapy remains challenging. The application of kinase inhibitors (KIs) in HNSCC, specifically mTOR and DNA-PK inhibitor
Externí odkaz:
https://doaj.org/article/f6291f0db6ec4d45ab73aad43015330e
Autor:
Andrey Anisenko, Simon Galkin, Andrey A. Mikhaylov, Maria G. Khrenova, Yulia Agapkina, Sergey Korolev, Lidia Garkul, Vasilissa Shirokova, Viktoria A. Ikonnikova, Alexander Korlyukov, Pavel Dorovatovskii, Mikhail Baranov, Marina Gottikh
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17354 (2023)
Integration of HIV-1 genomic cDNA results in the formation of single-strand breaks in cellular DNA, which must be repaired for efficient viral replication. Post-integration DNA repair mainly depends on the formation of the HIV-1 integrase complex wit
Externí odkaz:
https://doaj.org/article/34b2bcd3dccc4e55ba1438fb0fc9b7ed