RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements

Autor: Chatagnon, Amandine, Veber, Philippe, Morin, Valérie, Bedő, Justin, Triqueneaux, Gérard, Sémon, Marie, Laudet, Vincent, D'Alché-Buc, Florence, Benoît, Gérard

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2015, 43 (10), pp.4833--4854
Nucleic Acids Research, Oxford University Press, 2015, 43 (10), pp.4833--4854. ⟨10.1093/nar/gkv370⟩
Nucleic Acids Research, 2015, 43 (10), pp.4833--4854. ⟨10.1093/nar/gkv370⟩

International audience; In mouse embryonic cells, ligand-activated retinoic acid receptors (RARs) play a key role in inhibiting pluripotency-maintaining genes and activating some major actors of cell differentiation. To investigate the mechanism unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d02708d7b16147e7599b7534e5ecce8
https://hal.archives-ouvertes.fr/hal-01170316

E-box-independent regulation of transcription and differentiation by MYC

Autor: Uribesalgo I., Buschbeck M., Gutiérrez A., Teichmann S., Demajo S., Kuebler B., Nomdedéu J.F., Marté-N-Caballero J., Roma G., Benitah S.A., Di Croce L.

Publikováno v: NATURE CELL BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

MYC proto-oncogene is a key player in cell homeostasis that is commonly deregulated in human carcinogenesis 1. MYC can either activate or repress target genes by forming a complex with MAX (ref.2). MYC also exerts MAX-independent functions that are n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::42ed7347a80cd3cea4bfe1bf7b98a969
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10531

Up-Regulation of placental leptin by human chorionic gonadotropin

Autor: Maymó, J.L., Pérez, A.P., Sánchez-Margalet, V., Dueñas, J.L., Calvo, J.C., Varone, C.L.

Publikováno v: Endocrinology 2009;150(1):304-313
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Leptin, the 16,000 molecular weight protein product of the obese gene, was originally considered as an adipocyte-derived signaling moleculeforthe central control of metabolism. However, leptin has been suggested to be involved in other functions duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::3df1ffed7d9376f24f058b7e84664fae

Unliganded estrogen receptor-α activates transcription of the mammary gland Na+/I- symporter gene

Autor: Hani Alotaibi, Elif Yaman, Uygar H. Tazebay, Ediz Demirpençe

Publikováno v: Biochemical and Biophysical Research Communications

The function of sodium iodide symporter (Na+/I- symporter, or NIS) in mammary epithelial cells is essential for the accumulation of I- in milk; the newborn's first source of I- for thyroid hormone synthesis. Furthermore increased mammary gland NIS ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8395cc2f07f5a7bf275523f1a1a12f
https://hdl.handle.net/11693/23761

Bromobenzene-induced hepatotoxicity at the transcriptome level

Autor: Ben van Ommen, Wilbert H.M. Heijne, Angela L. Slitt, Rob H. Stierum, Curtis D. Klaassen, John P. Groten, T. Peter J. Van Bladeren

Publikováno v: Toxicological sciences, 79(2), 411-422
Toxicological sciences 79 (2004) 2
Toxicological Sciences, 2, 79, 411-422

Rats were exposed to three levels of bromobenzene, sampled at 6, 24, and 48 h, and liver gene expression profiles were determined to identify dose and time-related changes. Expression of many genes changed transiently, and dependent on the dose. Few

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688c4d644d58d9c7283a67464291e192
https://research.wur.nl/en/publications/bromobenzene-induced-hepatotoxicity-at-the-transcriptome-level