Zobrazeno 1 - 10
of 584
pro vyhledávání: '"DNA replication stress"'
Autor:
Anita G. Kansy, Ramy Ashry, Al‐Hassan M. Mustafa, Abdallah M. Alfayomy, Markus P. Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1958-1965 (2024)
Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia‐telangiectasia‐and‐RAD3‐rela
Externí odkaz:
https://doaj.org/article/3c603aa7f4ed49c783038eaa1696cb4c
Autor:
Christoph Hieber, Al-Hassan M. Mustafa, Sarah Neuroth, Sven Henninger, Hans-Peter Wollscheid, Joanna Zabkiewicz, Michelle Lazenby, Caroline Alvares, Siavosh Mahboobi, Falk Butter, Walburgis Brenner, Matthias Bros, Oliver H. Krämer
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117076- (2024)
Hyperactive FMS-like receptor tyrosine kinase-3 mutants with internal tandem duplications (FLT3-ITD) are frequent driver mutations of aggressive acute myeloid leukemia (AML). Inhibitors of FLT3 produce promising results in rationally designed cotreat
Externí odkaz:
https://doaj.org/article/92a388417b2242c48063d7ece8629a1e
Autor:
Dengfeng Zhang, Fangchao Zhao, Jing Li, Pengfei Guo, Haitao Liu, Tianxing Lu, Shujun Li, Zhirong Li, Yishuai Li
Publikováno v:
Translational Oncology, Vol 44, Iss , Pp 101948- (2024)
Background: Esophageal squamous cell carcinoma (ESCC) is a genetically heterogeneous disease with poor clinical outcomes. Identification of biomarkers linked to DNA replication stress may enable improved prognostic risk stratification and guide thera
Externí odkaz:
https://doaj.org/article/79917d2ae0544a398acf9d439b644122
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The accuracy of replication is one of the most important mechanisms ensuring the stability of the genome. The fork protection complex prevents premature replisome stalling and/or premature disassembly upon stress. Here, we characterize the Timeless
Externí odkaz:
https://doaj.org/article/ef3ac43d26ae4b4599a0f692579abb1c
Publikováno v:
Current Research in Toxicology, Vol 6, Iss , Pp 100152- (2024)
Heavy metals (HMs) are environmental pollutants that pose a threat to human health and have been accepted to cause various diseases, including cancer and developmental disorders. DNA replication stress has been identified to be associated with such d
Externí odkaz:
https://doaj.org/article/aef33e01b0fd4f1dad5afc5676d2e202
Autor:
Ya-nan MENG, Xin-jie ZHANG, Fan-li ZENG, Wei-bo ZHAI, Pan LI, Jing-jing HU, Sheng-lin XIAO, Zhi-min HAO, Zhi-yan CAO, Chuan CHEN, Jin-gao DONG
Publikováno v:
Journal of Integrative Agriculture, Vol 22, Iss 4, Pp 1068-1081 (2023)
The fungal pathogen Setosphaeria turcica causes northern corn leaf blight (NCLB), which leads to considerable crop losses. Setosphaeria turcica elaborates a specialized infection structures called appressorium for maize infection. Previously, we demo
Externí odkaz:
https://doaj.org/article/571e2c4c16ff44849240ee947b7edc7d
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Recent studies have identified DNA replication stress as an important feature of advanced prostate cancer (PCa). The identification of biomarkers for DNA replication stress could therefore facilitate risk stratification and help inform treat
Externí odkaz:
https://doaj.org/article/41324f8366044a83aad80565245c34dd
Autor:
Lopamudra Sadhu, Nikolaos Tsopoulidis, Md Hasanuzzaman, Vibor Laketa, Michael Way, Oliver T Fackler
Publikováno v:
eLife, Vol 12 (2023)
CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3 complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling. Actin polymerization dynamics and filament morphology differ between nuc
Externí odkaz:
https://doaj.org/article/d00d81b2ab4d4bc9802cbc22defe29ad
Publikováno v:
Cells, Vol 12, Iss 22, p 2607 (2023)
Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand. Replisomes consist of two functional units, a helicase
Externí odkaz:
https://doaj.org/article/9f612cd2da4c4825bd14a071e16b1869
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