Zobrazeno 1 - 10
of 350
pro vyhledávání: '"DNA replication and recombination"'
Autor:
Kathrin Allkanjari, Robert A. Baldock
Publikováno v:
Bioscience Reports
Mitochondria are highly specialised organelles required for key cellular processes including ATP production through cellular respiration and controlling cell death via apoptosis. Unlike other organelles, mitochondria contain their own DNA genome whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47631c9bc91feb1abed32324b19307e
https://pubmed.ncbi.nlm.nih.gov/34608928
https://pubmed.ncbi.nlm.nih.gov/34608928
Autor:
Susana Llanos, Karun Mutreja, Patricia Ubieto-Capella, Samuel Miguez, Daniel González-Acosta, Juan Méndez, Fernando García, Elena Blanco-Romero, Javier Munoz, Luis Blanco, Massimo Lopes
Publikováno v:
The EMBO Journal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
DNA interstrand crosslinks (ICLs) induced by endogenous aldehydes or chemotherapeutic agents interfere with essential processes such as replication and transcription. ICL recognition and repair by the Fanconi Anemia pathway require the formation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a717473159ed5bb2d03523f9e1edcb69
https://doi.org/10.15252/embj.2020106355
https://doi.org/10.15252/embj.2020106355
Publikováno v:
The EMBO Journal
The eukaryotic replisome is rapidly disassembled during DNA replication termination. In metazoa, the cullin‐RING ubiquitin ligase CUL‐2LRR‐1 drives ubiquitylation of the CMG helicase, leading to replisome disassembly by the p97/CDC‐48 “unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9119b29ea961c229495c12108e47927
https://pubmed.ncbi.nlm.nih.gov/34269473
https://pubmed.ncbi.nlm.nih.gov/34269473
Autor:
Joshua Z Johnson, Dirk Hockemeyer, Kelsey M. Hennick, Brendan Finnerty, Mary L McMaster, Ryan Forster, Casey Drubin, Sarah B. Short, Won-Tae Kim, Seung-A Sara Choo
Publikováno v:
The EMBO Journal
Mutations in the shelterin protein POT1 are associated with chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, angiosarcoma, melanoma, and other cancers. These cancer‐associated POT1 (caPOT1) mutations are generally heterozygous, missense, or no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc0beae85ffabd033b66f635ee3e4af
http://europepmc.org/articles/PMC8204863
http://europepmc.org/articles/PMC8204863
Publikováno v:
EMBO Reports
During DNA replication, the deubiquitinating enzyme USP1 limits the recruitment of translesion polymerases by removing ubiquitin marks from PCNA to allow specific regulation of the translesion synthesis (TLS) pathway. USP1 activity depends on an allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e1f0332c9c27125d26a750f484bdee
https://doi.org/10.15252/embr.202051749
https://doi.org/10.15252/embr.202051749
Autor:
Thomas A. Guilliam, Joseph Tp Yeeles
Publikováno v:
The EMBO Journal
The high‐fidelity replicative DNA polymerases, Pol ε and Pol δ, are generally thought to be poorly equipped to replicate damaged DNA. Direct and complete replication of a damaged template therefore typically requires the activity of low‐fidelit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2ebeb6db18019826b04d3bf4125f3
https://doi.org/10.15252/embj.2020107037
https://doi.org/10.15252/embj.2020107037
Autor:
Sanaa Jehi, Xiaohua Wu, Takuya Chiba, Zefeng Wang, Jun Li, Zi Wang, Lan Truong, Hailong Wang, Shuo Liu, Shibo Li
Publikováno v:
The EMBO Journal
Break‐induced replication (BIR) is a specialized homologous‐recombination pathway for DNA double‐strand break (DSB) repair, which often induces genome instability. In this study, we establish EGFP‐based recombination reporters to systematical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a517a66080b01e162a7ddf4bd3d7549c
https://doi.org/10.15252/embj.2020104509
https://doi.org/10.15252/embj.2020104509
Autor:
Ulrike Kühbacher, Irene Gallina, Julio C Y Liu, Yoshiaki Azuma, Nicolai B. Larsen, Claire Guérillon, Nikoline Borgermann, Niels Mailand, Ronald T. Hay, Emma Branigan, Leena Ackermann, Dimitriya H Garvanska, Ivo A. Hendriks, Michael L. Nielsen, Peter Haahr, Julien P. Duxin
Publikováno v:
Liu, J C Y, Kühbacher, U, Larsen, N B, Borgermann, N, Garvanska, D H, Hendriks, I A, Ackermann, L, Haahr, P, Gallina, I, Guérillon, C, Branigan, E, Hay, R T, Azuma, Y, Nielsen, M L, Duxin, J P & Mailand, N 2021, ' Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway ', E M B O Journal, vol. 40, e107413 . https://doi.org/10.15252/embj.2020107413
The EMBO Journal
The EMBO Journal
DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fd624e33a326d63e7e57078ba37ff6
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf
Autor:
Fabrizio, Villa, Ryo, Fujisawa, Johanna, Ainsworth, Kohei, Nishimura, Michael, Lie-A-Ling, Georges, Lacaud, Karim Pm, Labib
Publikováno v:
EMBO Reports
The eukaryotic replisome is disassembled in each cell cycle, dependent upon ubiquitylation of the CMG helicase. Studies of Saccharomyces cerevisiae, Caenorhabditis elegans and Xenopus laevis have revealed surprising evolutionary diversity in the ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96606a21a189736f24ff166d1b1a94bd
https://pubmed.ncbi.nlm.nih.gov/33590678
https://pubmed.ncbi.nlm.nih.gov/33590678
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
The EMBO Journal
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
The EMBO Journal
© 2020 The Authors.
The juxtaposition of intracellular DNA segments, together with the DNA-passage activity of topoisomerase II, leads to the formation of DNA knots and interlinks, which jeopardize chromatin structure and gene expression. Recen
The juxtaposition of intracellular DNA segments, together with the DNA-passage activity of topoisomerase II, leads to the formation of DNA knots and interlinks, which jeopardize chromatin structure and gene expression. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f06fe6b8dcf1097f9b427b4f48a9d2
https://doi.org/10.15252/embj.2020105393
https://doi.org/10.15252/embj.2020105393