Zobrazeno 1 - 10
of 306
pro vyhledávání: '"DNA repair pathways"'
Autor:
Yunhui Li, Lei Li, Xinshu Wang, Fei Zhao, Yuntong Yang, Yujuan Zhou, Jiyuan Zhang, Li Wang, Zeshan Jiang, Yuanyuan Zhang, Yuping Chen, Chenming Wu, Ke Li, Tingting Zhang, Ping Wang, Zhiyong Mao, Weiguo Zhu, Xingzhi Xu, Shikang Liang, Zhenkun Lou, Jian Yuan
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract DNA damage plays a significant role in the tumorigenesis and progression of the disease. Abnormal DNA repair affects the therapy and prognosis of cancer. In this study, it is demonstrated that the deubiquitinase USP25 promotes non‐homologo
Externí odkaz:
https://doaj.org/article/15c5e763094144a7a13720809e1edf7a
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Toxoplasma gondii is a globally occurring apicomplexan parasite that infects humans and animals. Globally, different typical and atypical haplotypes of T. gondii induce varying pathologies in hosts. As an obligate intracellular protozoon, T. gondii w
Externí odkaz:
https://doaj.org/article/4447c5d391d142b7a9194b2e0908e0bb
Autor:
Oleg Belov, Anna Chigasova, Margarita Pustovalova, Andrey Osipov, Petr Eremin, Natalia Vorobyeva, Andreyan N. Osipov
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7352-7373 (2023)
Understanding the relative contributions of different repair pathways to radiation-induced DNA damage responses remains a challenging issue in terms of studying the radiation injury endpoints. The comparative manifestation of homologous recombination
Externí odkaz:
https://doaj.org/article/417834f39ddb49c6bb46ade8706c120c
Autor:
Jessica Honorato Ribeiro, Nazlican Altinisik, Nicholas Rajan, Mieke Verslegers, Sarah Baatout, Jay Gopalakrishnan, Roel Quintens
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the basic structure of the DNA. Dif
Externí odkaz:
https://doaj.org/article/ed3e26e6bfff45288688e7af1f7209da
Autor:
Rita Manguinhas, Patrícia A. Serra, Rita B. Soares, Rafael Rosell, Nuno Gil, Nuno G. Oliveira, Rita C. Guedes
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1246 (2024)
Modifications in DNA repair pathways are recognized as prognostic markers and potential therapeutic targets in various cancers, including non-small cell lung cancer (NSCLC). Overexpression of ERCC1 correlates with poorer prognosis and response to pla
Externí odkaz:
https://doaj.org/article/226cbff4531542b4a0a68dd5fa711acc
Autor:
Wejdan M. Alenezi, Caitlin T. Fierheller, Corinne Serruya, Timothée Revil, Kathleen K. Oros, Deepak N. Subramanian, Jeffrey Bruce, Dan Spiegelman, Trevor Pugh, Ian G. Campbell, Anne-Marie Mes-Masson, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Guy Rouleau, Luigi Bouchard, Celia M. T. Greenwood, Jiannis Ragoussis, Patricia N. Tonin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic variants in familial OC cases
Externí odkaz:
https://doaj.org/article/05d239ab593d4e42b75d51380a913fb1
Publikováno v:
Cancer Reports, Vol 5, Iss 11, Pp n/a-n/a (2022)
Abstract Esophageal cancer (EC) is a common malignancy with a poor prognosis worldwide. There are two core pathways that repair double‐strand breaks, homologous recombination (HR) and non‐homologous end joining (NHEJ) and numerous proteins are re
Externí odkaz:
https://doaj.org/article/78c3af6d7c0d4a1882369bba5157e2f3
Akademický článek
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Autor:
Skjetne, Alexander Myhr
Publikováno v:
Skjetne, Alexander Myhr. Unraveling the Impact of DNA Glycosylase NTHL1 on Mitochondrial Function and Dynamics. Master thesis, University of Oslo, 2023
Externí odkaz:
http://hdl.handle.net/10852/110049
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/4aa84d7e028048628d74da91e627c681