Zobrazeno 1 - 10
of 1 897
pro vyhledávání: '"DNA mutation"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Precise calling of promiscuous adenosine-to-inosine RNA editing sites from transcriptomic datasets is hindered by DNA mutations and sequencing/mapping errors. Here, we present a stepwise computational framework, called DEMINING, to distingui
Externí odkaz:
https://doaj.org/article/f250557117004a70885cf075c934198f
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Thus far, multiple techniques for single cell analysis have been developed, yet we lack a relatively simple tool to assess DNA and RNA from the same cell at whole-transcriptome and whole-genome depths. Here we present an updated method for p
Externí odkaz:
https://doaj.org/article/d30f840a68e64985abe453e2bee267a9
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations occurring in nucleic acids or proteins may affect the binding affinities of protein-nucleic acid interactions. Although many efforts have been devoted to the impact of protein mutations, few computational studies have ad
Externí odkaz:
https://doaj.org/article/228c65b0bb634957af2b56172b1d59ea
Autor:
Le Wang, Zhou Gong, Ming Wang, Yi-Zhong Liang, Jing Zhao, Qi Xie, Xiao-Wei Wu, Qin-Ying Li, Cong Zhang, Li-Yun Ma, Si-Yang Zheng, Ming Jiang, Xu Yu, Li Xu
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 292-304 (2025)
Extracellular vesicles (EVs) have garnered significant attention in biomedical applications. However, the rapid, efficient, and unbiased separation of EVs from complex biological fluids remains a challenge due to their heterogeneity and low abundance
Externí odkaz:
https://doaj.org/article/ff22c6c76df54b7b9e0416c20c0b34ec
Autor:
Won-Gun Yun, Daeun Kim, Mirang Lee, Youngmin Han, Yoon Soo Chae, Hye-Sol Jung, Young Jae Cho, Wooil Kwon, Joon Seong Park, Daechan Park, Jin-Young Jang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Pancreatic cancer is anatomically divided into pancreatic head and body/tail cancers, and some studies have reported differences in prognosis. However, whether this discrepancy is induced from the difference of tumor biology is ho
Externí odkaz:
https://doaj.org/article/434a2ece2fe4452d9fc851fc1be36daf
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT Gut microbe dysbiosis increases repetitive inflammatory responses, leading to an increase in the incidence of colorectal cancer. Recent studies have revealed that specific microbial species directly instigate mutations in the host nucleus DN
Externí odkaz:
https://doaj.org/article/1787e1b2774347a28f3b27eebfcd90e6
Autor:
Ghorbel Dhoha, Amouri Imen, Khemekhem Nahed, Neji Sourour, Trabelsi Houaida, Elloumi Moez, Sellami Hayet, Makni Fattouma, Ayadi Ali, Hadrich Ines
Publikováno v:
Polish Journal of Microbiology, Vol 73, Iss 2, Pp 131-142 (2024)
This study aimed to investigate azole resistance mechanisms in Aspergillus flavus, which involve cyp51A and cyp51B genes. Real-time Reverse Transcriptase qPCR method was applied to determine the overexpression of cyp51A and cyp51B genes for 34 A. fla
Externí odkaz:
https://doaj.org/article/b9b4b7d9886d438ca713af04edd90e67
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-5 (2024)
Abstract In order to explore the spectrum of mitochondrial DNA (mtDNA) mutations in Korean patients with Leber's hereditary optic neuropathy (LHON), we investigated the spectrum of mtDNA mutations in 145 Korean probands confirmed with the diagnosis o
Externí odkaz:
https://doaj.org/article/f6b7000164654c23808164030a7abaca
Publikováno v:
Oral Oncology Reports, Vol 10, Iss , Pp 100513- (2024)
Oral squamous cell carcinoma (OSCC) is a common type of tumor that develops in the mucosal epithelium of the oral cavity. Approximately 377,713 OSCC cases were reported worldwide, and the incidence of OSCC is expected to increase by approximately 40
Externí odkaz:
https://doaj.org/article/37f9034523444eb5863623b31d8f1008
Autor:
Maher Kurdi, Ahmed Bamaga, Alaa Alkhotani, Thamer Alsharif, Ghada A Abdel-Hamid, Mohamed E Selim, Taghreed Alsinani, Ahmed Albeshri, Adnan Badahdah, Mazen Basheikh, Saleh Baeesa
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 10, p 367 (2024)
Metabolic reprogramming within tumor cells involves a shift towards either glycolysis or mitochondrial respiration, depending on the stage of tumor progression. Consequently, irreversible dysfunction of the mitochondria is considered a crucial mechan
Externí odkaz:
https://doaj.org/article/948bafbb0ddc477bb5ebd03d8ea4c5ae