DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas

Autor: Helena Carén, Asgeir Store Jakola, Thomas Olsson Bontell, Sandra Ferreyra Vega, Alba Corell, Anja Smits

Publikováno v: Clinical Epigenetics

BackgroundDNA methylation profiling has facilitated and improved the classification of a wide variety of tumors of the central nervous system. In this study, we investigated the potential utility of DNA methylation profiling to achieve molecular diag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d063d0ecdaa906a3295f23ab12c944e
https://doi.org/10.1186/s13148-021-01085-7

DNA methylation-based classification of central nervous system tumours

Autor: Till Milde, Matija Snuderl, Martin Bendszus, Ralf Ketter, Catherine Keohane, Marco Prinz, Katja von Hoff, Aristotelis Tsirigos, Hildegard Dohmen, Manfred Westphal, Ute Pohl, Gabriele Schackert, Christian Koelsche, Eleonora Aronica, Bernhard Radlwimmer, Bjarne Winther Kristensen, Martin Hasselblatt, David T.W. Jones, Christian Mawrin, Dominik Sturm, Patricia Kohlhof, Peter Lichter, Annekathrin Kratz, Anne K. Braczynski, Helmut Mühleisen, Wolf Mueller, Wolfgang Brück, Stephan Frank, Andreas Unterberg, Michael Weller, Matthias A. Karajannis, Astrid Gnekow, Lukas Chavez, Andreas E. Kulozik, Christoph Geisenberger, Christine Haberler, Ori Staszewski, Amar Gajjar, Stephanie Rozsnoki, Mélanie Pagès, Olaf Witt, Paul A. Northcott, Matt Lechner, Thomas S. Jacques, Martina Deckert, Axel Benner, Jordan R. Hansford, Ingmar Blümcke, Marina Ryzhova, Gudrun Fleischhack, Jonathan Serrano, Jens Schittenhelm, Martin Sill, Sebastian Brandner, Stephan Tippelt, Dietmar R. Lohmann, Hermann L. Müller, Petra Temming, Nils W. Engel, Khalida Wani, Pablo Hernáiz Driever, Christel Herold-Mende, David W. Ellison, Arie Perry, Michael C. Frühwald, Stefan M. Pfister, Christof M. Kramm, Stefanie Brehmer, Daniel Hänggi, Jane Cryan, Torsten Pietsch, Wolfram Scheurlen, Marcel Seiz-Rosenhagen, Volkmar Hans, Adriana Olar, Werner Paulus, Chris Jones, Annie Huang, Patrick N. Harter, Felice Giangaspero, Marcel Kool, Kenneth Aldape, Marco Gessi, Silvia Hofer, Fausto J. Rodriguez, Anne Jouvet, Roland Coras, Annika K. Wefers, Leonille Schweizer, Vincent Peter Collins, Beatriz Lopes, Rolf Bjerkvig, Matthias Schick, Michel Mittelbronn, Andrey Korshunov, Johannes Schramm, Marc Zapatka, Annett Hölsken, Michael Platten, Kerstin Lindenberg, Jürgen Debus, Christian Hartmann, Ekkehard Hewer, Pascale Varlet, Melanie Bewerunge-Hudler, Till Acker, Matthias Preusser, Elisabeth J. Rushing, Michael A. Farrell, Kristian W. Pajtler, Nada Jabado, Kasthuri Kannan, Wolfgang Wick, David E. Reuss, Rolf Buslei, Nicholas G. Gottardo, Giles W. Robinson, Stefan Rutkowski, Jürgen Hench, Andreas von Deimling, Ulrich Schüller, Zane Jaunmuktane, Pieter Wesseling, Hendrik Witt, Albert J. Becker, Frank L. Heppner, Roger Fischer, Ziad Khatib, Guido Reifenberger, Arend Koch, Gabriele Calaminus, Karl H. Plate, Volker Hovestadt, Michael D. Taylor, Camelia-Maria Monoranu, Damian Stichel, Felix Sahm, Kristin Huang, David Capper, Florian Selt, Daniel Schrimpf, Rudi Beschorner, Boyan K. Garvalov

Publikováno v: Nature, 555(7697), 469-474. Nature Publishing Group
Nature, 555(7697), 469. Nature Publishing Group
Capper, D, Jones, D T W, Sill, M, Hovestadt, V, Schrimpf, D, Sturm, D, Koelsche, C, Sahm, F, Chavez, L, Reuss, D E, Kratz, A, Wefers, A K, Huang, K, Pajtler, K W, Schweizer, L, Stichel, D, Olar, A, Engel, N W, Lindenberg, K, Harter, P N, Braczynski, A K, Plate, K H, Dohmen, H, Garvalov, B K, Coras, R, Hölsken, A, Hewer, E, Bewerunge-Hudler, M, Schick, M, Fischer, R, Beschorner, R, Schittenhelm, J, Staszewski, O, Wani, K, Varlet, P, Pages, M, Temming, P, Lohmann, D, Selt, F, Witt, H, Milde, T, Witt, O, Aronica, E, Giangaspero, F, Rushing, E, Scheurlen, W, Geisenberger, C, Rodriguez, F J, Becker, A, Preusser, M, Haberler, C, Bjerkvig, R, Cryan, J, Farrell, M, Deckert, M, Hench, J R, Frank, S, Serrano, J, Kannan, K, Tsirigos, A, Brück, W, Hofer, S, Brehmer, S, Seiz-Rosenhagen, M, Hänggi, D, Hans, V, Rozsnoki, S, Hansford, J R, Kohlhof, P, Kristensen, B W, Lechner, M, Lopes, B, Mawrin, C, Ketter, R, Kulozik, A, Khatib, Z, Heppner, F, Koch, A, Jouvet, A, Keohane, C, Mühleisen, H, Mueller, W, Pohl, U, Prinz, M, Benner, A, Zapatka, M, Gottardo, N G, Driever, P H, Kramm, C M, Müller, H L, Rutkowski, S, von Hoff, K, Frühwald, M C, Gnekow, A, Fleischhack, G, Tippelt, S, Calaminus, G, Monoranu, C-M, Perry, A, Jones, C, Jacques, T S, Radlwimmer, B, Gessi, M, Pietsch, T, Schramm, J, Schackert, G, Westphal, M, Reifenberger, G, Wesseling, P, Weller, M, Collins, V P, Blümcke, I, Bendszus, M, Debus, J R, Huang, A, Jabado, N, Northcott, P A, Paulus, W, Gajjar, A, Robinson, G W, Taylor, M D, Jaunmuktane, Z, Ryzhova, M, Platten, M, Unterberg, A, Wick, W, Karajannis, M A, Mittelbronn, M, Acker, T, Hartmann, C, Aldape, K, Schüller, U, Buslei, R, Lichter, P, Kool, M, Herold-Mende, C, Ellison, D W, Hasselblatt, M, Snuderl, M, Brandner, S, Korshunov, A, von Deimling, A & Pfister, S M 2018, ' DNA methylation-based classification of central nervous system tumours ', Nature, vol. 555, no. 7697, pp. 469-474 . https://doi.org/10.1038/nature26000
Capper, D, Jones, D T W, Sill, M, Hovestadt, V, Schrimpf, D, Sturm, D, Koelsche, C, Sahm, F, Chavez, L, Reuss, D E, Kratz, A, Wefers, A K, Huang, K, Pajtler, K W, Schweizer, L, Stichel, D, Olar, A, Engel, N W, Lindenberg, K, Harter, P N, Braczynski, A K, Plate, K H, Dohmen, H, Garvalov, B K, Coras, R, Hölsken, A, Hewer, E, Bewerunge-Hudler, M, Schick, M, Fischer, R, Beschorner, R, Schittenhelm, J, Staszewski, O, Wani, K, Varlet, P, Pages, M, Temming, P, Lohmann, D, Selt, F, Witt, H, Milde, T, Witt, O, Aronica, E, Giangaspero, F, Rushing, E, Scheurlen, W, Geisenberger, C, Rodriguez, F J, Becker, A, Preusser, M, Haberler, C, Bjerkvig, R, Cryan, J, Farrell, M, Deckert, M, Hench, J, Frank, S, Serrano, J, Kannan, K, Tsirigos, A, Brück, W, Hofer, S, Brehmer, S, Seiz-Rosenhagen, M, Hänggi, D, Hans, V, Rozsnoki, S, Hansford, J R, Kohlhof, P, Kristensen, B W, Lechner, M, Lopes, B, Mawrin, C, Ketter, R, Kulozik, A, Khatib, Z, Heppner, F, Koch, A, Jouvet, A, Keohane, C, Mühleisen, H, Mueller, W, Pohl, U, Prinz, M, Benner, A, Zapatka, M, Gottardo, N G, Driever, P H, Kramm, C M, Müller, H L, Rutkowski, S, Von Hoff, K, Frühwald, M C, Gnekow, A, Fleischhack, G, Tippelt, S, Calaminus, G, Monoranu, C M, Perry, A, Jones, C, Jacques, T S, Radlwimmer, B, Gessi, M, Pietsch, T, Schramm, J, Schackert, G, Westphal, M, Reifenberger, G, Wesseling, P, Weller, M, Collins, V P, Blümcke, I, Bendszus, M, Debus, J, Huang, A, Jabado, N, Northcott, P A, Paulus, W, Gajjar, A, Robinson, G W, Taylor, M D, Jaunmuktane, Z, Ryzhova, M, Platten, M, Unterberg, A, Wick, W, Karajannis, M A, Mittelbronn, M, Acker, T, Hartmann, C, Aldape, K, Schüller, U, Buslei, R, Lichter, P, Kool, M, Herold-Mende, C, Ellison, D W, Hasselblatt, M, Snuderl, M, Brandner, S, Korshunov, A, Von Deimling, A & Pfister, S M 2018, ' DNA methylation-based classification of central nervous system tumours ', Nature, vol. 555, no. 7697, pp. 469-474 . https://doi.org/10.1038/nature26000

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5047d9e6db898ab95d5c17d081d6d9b6
https://doi.org/10.1038/nature26000

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Coexistence of Two Distinct Tumor Types Within One Posterior Fossa Mass Lesion in an Adult Patient Verified by DNA-Methylation Analysis: A Case Report.

Autor: Rezai A; Department of Neurological Surgery, University Hospital Salzburg, Salzburg, AUT., Pöppe JP; Department of Neurological Surgery, University Hospital Salzburg, Salzburg, AUT., Spendel M; Department of Neurological Surgery, University Hospital Salzburg, Salzburg, AUT., Kraus TFJ; Department of Pathology, University Hospital Salzburg, Salzburg, AUT., Stevanovic V; Department of Neuroradiology, University Hospital Salzburg, Salzburg, AUT., Griessenauer CJ; Department of Neurological Surgery, University Hospital Salzburg, Salzburg, AUT., Schwartz C; Department of Neurological Surgery, University Hospital Salzburg, Salzburg, AUT.

Publikováno v: Cureus [Cureus] 2023 Feb 17; Vol. 15 (2), pp. e35111. Date of Electronic Publication: 2023 Feb 17 (Print Publication: 2023).