The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes

Autor: Tanya T. Paull, Rajashree A. Deshpande

Publikováno v: Experimental Cell Research. 329:139-147

DNA double-strand breaks (DSBs) can arise from internal or external sources of damage, and the rapid detection, processing, and repair of this damage is important for cell viability. Failure to repair DNA damage can result in genomic instability, ult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5619c3ef0809022ca9237e33678df0
https://doi.org/10.1016/j.yexcr.2014.07.007

Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection

Autor: Mika Higashide, Miki Shinohara, Daichi Iwasaki, Kenichiro Matsuzaki, Masahiro Terasawa

Publikováno v: Genes to Cells. 17:473-493

DNA double-strand breaks (DSBs) are repaired by two distinct pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ). NHEJ includes two pathways, that is, precise and imprecise end joining. We found that Lif1, a component of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e645ea4a79c73072b77191e8108e60dd
https://doi.org/10.1111/j.1365-2443.2012.01602.x

Werner Protein Cooperates with the XRCC4-DNA Ligase IV Complex in End-Processing

Autor: Jae Wan Lee, Vilhelm A. Bohr, Dale A. Ramsden, Alessandro Vindigni, Lala Dawut, Caterina Marchetti, Rika Kusumoto

Publikováno v: Biochemistry. 47:7548-7556

Werner syndrome is a rare human disease characterized by the premature onset of aging-associated pathologies, cancer predisposition, and genomic instability. The Werner protein (WRN), which is defective in Werner syndrome ( WS) patients, belongs to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d42b22f781bc82e91f67c65e1704f6
https://doi.org/10.1021/bi702325t

Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1

Autor: Isabelle Callebaut, Laurent Malivert, Alain Fischer, Patrick Revy, Jean-Pierre de Villartay, Jean-Paul Mornon

Publikováno v: Journal of Biological Chemistry. 281:13857-13860

DNA double strand breaks are considered as the most harmful DNA lesions and are repaired by either homologous recombination or nonhomologous end joining (NHEJ). A new NHEJ factor, Cernunnos, has been identified, the defect of which leads to a severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0d627e5607527a9fbf777f133d92b7
https://doi.org/10.1074/jbc.c500473200

XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation

Autor: Mauro Modesti, Eric A. Hendrickson, Aurélie Négrel, Abinadabe J. de Melo, Yao Xu, Satish K. Tadi, Katheryn Meek, Sunetra Roy

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, 2015, 35 (17), pp.3017-3028. ⟨10.1128/MCB.01503-14⟩
Molecular and Cellular Biology, American Society for Microbiology, 2015, 35 (17), pp.3017-3028. ⟨10.1128/MCB.01503-14⟩

International audience; The classic nonhomologous end-joining (c-NHEJ) pathway is largely responsible for repairing double-strand breaks (DSBs) in mammalian cells. XLF stimulates the XRCC4/DNA ligase IV complex by an unknown mechanism. XLF interacts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ea3e5e69ef318f3ada849892d1c733
https://hal-amu.archives-ouvertes.fr/hal-01456279