Zobrazeno 1 - 10
of 943
pro vyhledávání: '"DNA hypermethylation"'
Autor:
Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou, Shenmeng Gao
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells have high miR-182 promot
Externí odkaz:
https://doaj.org/article/c44c05750ee741bc967316cdfdac82e9
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we identified a neural-related DNA hypermethylation fingerprint in colon cancer, where most of t
Externí odkaz:
https://doaj.org/article/d113780cc53e4c6fa7d09ae35a59955b
Autor:
Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros, Pedro P. Medina
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Background Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood. To date
Externí odkaz:
https://doaj.org/article/788bd0ba48a0443da4a16299d38495f1
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 39, Iss 3, Pp 278-289 (2023)
Abstract Much is known about the significance of lycorine, a natural alkaloid, in combating various types of cancer, including breast cancer (BC), but whether it participates in regulating tamoxifen (TAM) resistance and its underlying mechanism remai
Externí odkaz:
https://doaj.org/article/6392e914eaa746f1affc4d67a5a137a3
Akademický článek
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Akademický článek
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Publikováno v:
Epigenetics, Vol 16, Iss 9, Pp 940-954 (2021)
DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-)
Externí odkaz:
https://doaj.org/article/a1205ff93b954287bcba2de56d34fcec
Akademický článek
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Publikováno v:
Nanomaterials, Vol 13, Iss 12, p 1880 (2023)
DNA methylation is an epigenetic mechanism that involves the addition of a methyl group to a cytosine residue in CpG dinucleotides, which are particularly abundant in gene promoter regions. Several studies have highlighted the role that modifications
Externí odkaz:
https://doaj.org/article/8355d48277804460a045929f61b86321
Autor:
Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu, He Huang
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG). Mesenchymal stromal
Externí odkaz:
https://doaj.org/article/e3678970c94444db88a49af196dc0cef