Zobrazeno 1 - 10
of 3 067
pro vyhledávání: '"DNA double-strand breaks"'
Autor:
Mohsen Amirnorouzi, Ahmadmoeen Karimi, Naser Ebrahimi Daryani, Amiratabak Rajaei, Mehrdad Hashemi, Masoud Alebouyeh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract This study aimed to investigate the activation of error-prone DNA repair pathway in response to Helicobacter pylori infection. Relative changes in the expression levels of genes involved in the non-homologous end-joining pathway (NHEJ) in H.
Externí odkaz:
https://doaj.org/article/fb7f01585245439596647bd69f70ae25
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Non-obstructive azoospermia (NOA) is the most severe form of male infertility and affects approximately 1% of men worldwide. Fanconi anemia (FA) genes were known for their essential role in DNA repair and growing evidence showed t
Externí odkaz:
https://doaj.org/article/b1194e9fe356474696efa52078181b1a
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in ALS includes increased genomic damage and impaired DNA repair capability. The TAR-DNA bindin
Externí odkaz:
https://doaj.org/article/789bc818a5f940d18d10982b7e5cbe39
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The knowledge on responses of human lens epithelial cells (HLECs) to ionizing radiation exposure is important to understand mechanisms of radiation cataracts that are of concern in the field of radiation protection and radiation therapy. How
Externí odkaz:
https://doaj.org/article/6335fa9027ed459ba8778d6ec395cd44
Autor:
Samatha M Jain, Shruthi Nagainallur Ravichandran, Makalakshmi Murali Kumar, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Rupak Pathak, Xiao-Feng Sun, Surajit Pathak
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTRectal cancer accounts for the second highest cancer-related mortality, which is predominant in Western civilizations. The treatment for rectal cancers includes surgery, radiotherapy, chemotherapy, and immunotherapy. Radiotherapy, specificall
Externí odkaz:
https://doaj.org/article/f09ecb6416a149119986c17188c7dded
BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis
Autor:
Erik Toraason, Alina Salagean, David E Almanzar, Jordan E Brown, Colette M Richter, Nicole A Kurhanewicz, Ofer Rog, Diana E Libuda
Publikováno v:
eLife, Vol 13 (2024)
The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote
Externí odkaz:
https://doaj.org/article/5cc501e585fc4bf7b72400fd15e82b53
Publikováno v:
BMC Oral Health, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background N-acetylcysteine (NAC) reduces the cytotoxicity and genotoxicity induced by monomers leached from dental composite resins. Herein, we investigated the effects of methacrylate-based resin cement used in dental implant restoration o
Externí odkaz:
https://doaj.org/article/57884f59830f41ce8e1ff7557da68909
Autor:
Juliette Restier-Verlet, Mélanie L. Ferlazzo, Adeline Granzotto, Joëlle Al-Choboq, Camélia Bellemou, Maxime Estavoyer, Florentin Lecomte, Michel Bourguignon, Laurent Pujo-Menjouet, Nicolas Foray
Publikováno v:
Cells, Vol 13, Iss 20, p 1703 (2024)
Radiation impacting astronauts in their spacecraft come from a “bath” of high-energy rays (0.1–0.5 mGy per mission day) that reaches deep tissues like the heart and bones and a “stochastic rain” of low-energy particles from the shielding an
Externí odkaz:
https://doaj.org/article/c585ed05f6f7446786bab067939d326b
Autor:
Li-Kuang Tsai, Min Peng, Chia-Chun Chang, Luan Wen, Lin Liu, Xiubin Liang, Y. Eugene Chen, Jie Xu, Li-Ying Sung
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background In eukaryotic cells, DNA double strand breaks (DSB) are primarily repaired by canonical non-homologous end joining (c-NHEJ), homologous recombination (HR) and alternative NHEJ (alt-NHEJ). Zinc finger and SCAN domain containing 4 (
Externí odkaz:
https://doaj.org/article/7dffff95d442413cad8b10bee359437b
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 7915-7932 (2023)
Cisplatin (CDDP) is the cornerstone of standard treatment for ovarian cancer. However, the resistance of ovarian cancer cells to CDDP leads to an inevitable recurrence. One of the strategies to overcome resistance to CDDP is the combined treatment of
Externí odkaz:
https://doaj.org/article/90865093bc6944688c277fcc6835f3a9