Zobrazeno 1 - 10
of 1 033
pro vyhledávání: '"DNA double-strand break repair"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the D
Externí odkaz:
https://doaj.org/article/44b311a2d8f540fdb61b03090e943cce
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106675- (2024)
α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear
Externí odkaz:
https://doaj.org/article/21878170bbf543eb8878f2c707f5951b
Autor:
Mingyang Li, Genbao Shao
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1337 (2024)
Oxidative stress, driven by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), induces DNA double-strand breaks (DSBs) that compromise genomic integrity. The DNA Damage Response (DDR), primarily mediated by ATM and ATR kinases, is crucia
Externí odkaz:
https://doaj.org/article/4a3a3576e52f443cbe3da40b2db3e55a
The role of DNA double-strand break repair defects in the pathogenesis of neurodegenerative diseases
Publikováno v:
生物医学转化, Vol 4, Iss 2, Pp 31-41 (2023)
DNA double-strand break repair (DSBR) plays an important role in maintaining genome stability and cell survival. DSBR are predominately accomplished by two pathways: Homologous Recombination (HR) and Non-homologous End Joining (NHEJ), and both pathwa
Externí odkaz:
https://doaj.org/article/c4f19ad5c06f4bbbb8c4ed9ced05a093
Autor:
Chiaki Kinoshita, Yoshimasa Takizawa, Mika Saotome, Shun Ogino, Hitoshi Kurumizaka, Wataru Kagawa
Publikováno v:
FEBS Open Bio, Vol 13, Iss 3, Pp 408-418 (2023)
The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding. Crystallographic studies have reve
Externí odkaz:
https://doaj.org/article/b7da9833a3ae4018be877cbb8df200dd
Akademický článek
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Akademický článek
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Autor:
Si-Cheng Liu, Yi-Li Feng, Xiu-Na Sun, Ruo-Dan Chen, Qian Liu, Jing-Jing Xiao, Jin-Na Zhang, Zhi-Cheng Huang, Ji-Feng Xiang, Guo-Qiao Chen, Yi Yang, Chao Lou, Hao-Dan Li, Zhen Cai, Shi-Ming Xu, Hui Lin, An-Yong Xie
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways. Target interaction of Cas9-sgRNA determines its target binding
Externí odkaz:
https://doaj.org/article/3baeafdd016e47d9820a0acff3a8a5a0
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Background As a member of RNA-binding protein, CDKN2AIP has been shown to play a critical role in stem cell pluripotency and somatic differentiation. Recent studies indicate that Cdkn2aip is essential for spermatogonial self-renewal and prol
Externí odkaz:
https://doaj.org/article/d85ce58c771648048e8e716d1cf645b7