Zobrazeno 1 - 10
of 179
pro vyhledávání: '"DNA double-strand break (DSB)"'
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
DNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, many stud
Externí odkaz:
https://doaj.org/article/7751d5556522435ca788274cdf66af7c
Autor:
Asli Muvaffak, Kevin G. Coleman
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAtaxia telangiectasia-mutated (ATM) kinase is a central regulator of the DNA damage response (DDR) signaling pathway, and its function is critical for the maintenance of genomic stability in cells that coordinate a network of cellular proce
Externí odkaz:
https://doaj.org/article/25bed31213ed4a50acfbdf2081992ecd
Publikováno v:
Thoracic Cancer, Vol 14, Iss 16, Pp 1420-1429 (2023)
Abstract Background DNA damage repair is a crucial mechanism highly related to therapy resistance for various therapeutic strategies. Our previous results have shown that the degree of drug resistance in small‐cell lung cancer (SCLC) cell lines was
Externí odkaz:
https://doaj.org/article/ac24499ea68e4b75b65bb0641cbc8d73
Publikováno v:
Radiation Medicine and Protection, Vol 2, Iss 4, Pp 146-154 (2021)
Exonuclease 1 (EXO1) can catalyze nucleotide chain excision with its conserved N-terminal domain of 5′ to 3′ exonuclease activity, enabling it to influence diverse biological processes facing the challenges of genotoxic environmental factors such
Externí odkaz:
https://doaj.org/article/210fef7beb1440f28b32bace6ef2bf6e
Autor:
Sravan Kodali, Silvia Meyer-Nava, Stephen Landry, Arijita Chakraborty, Juan Carlos Rivera-Mulia, Wenyi Feng
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Common fragile sites (CFSs) are specific regions of all individuals’ genome that are predisposed to DNA double strand breaks (DSBs) and undergo subsequent rearrangements. CFS formation can be induced in vitro by mild level of DNA replication stress
Externí odkaz:
https://doaj.org/article/27dd44996eaf4511b53034ed211719df
Autor:
Jeremy M. Kelm, Amirreza Samarbakhsh, Athira Pillai, Pamela S. VanderVere-Carozza, Hariprasad Aruri, Deepti S. Pandey, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and DNA damage response (DDR) pathways. Aberrations in DNA repa
Externí odkaz:
https://doaj.org/article/74a34493f8cf45abaafceb2411d093e9
Autor:
Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1428 (2022)
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated
Externí odkaz:
https://doaj.org/article/3779506867d241bbb553524ad93677ff
Autor:
Nicole B. Averbeck, Carina Barent, Burkhard Jakob, Tatyana Syzonenko, Marco Durante, Gisela Taucher-Scholz
Publikováno v:
Cells, Vol 11, Iss 16, p 2561 (2022)
DNA double-strand breaks (DSBs) represent the molecular origin of ionizing-radiation inflicted biological effects. An increase in the ionization density causes more complex, clustered DSBs that can be processed by resection also in G1 phase, where re
Externí odkaz:
https://doaj.org/article/498e4747b7084cd5ae661080f597fdf6
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Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2020)
Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5′-phosphate, 3′-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair. Cells are therefore endowed with a wide
Externí odkaz:
https://doaj.org/article/9a017f3522214126836c7eabb22b45da