PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation

Autor: Asli Muvaffak, Kevin G. Coleman

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundAtaxia telangiectasia-mutated (ATM) kinase is a central regulator of the DNA damage response (DDR) signaling pathway, and its function is critical for the maintenance of genomic stability in cells that coordinate a network of cellular proce

Externí odkaz: https://doaj.org/article/25bed31213ed4a50acfbdf2081992ecd

Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

Autor: Jeremy M. Kelm, Amirreza Samarbakhsh, Athira Pillai, Pamela S. VanderVere-Carozza, Hariprasad Aruri, Deepti S. Pandey, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and DNA damage response (DDR) pathways. Aberrations in DNA repa

Externí odkaz: https://doaj.org/article/74a34493f8cf45abaafceb2411d093e9

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Boon and Bane of DNA Double-Strand Breaks

Autor: Ingo Schubert

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5171, p 5171 (2021)
International Journal of Molecular Sciences
International journal of molecular sciences, 22(10):5171

DNA double-strand breaks (DSBs), interrupting the genetic information, are elicited by various environmental and endogenous factors. They bear the risk of cell lethality and, if mis-repaired, of deleterious mutation. This negative impact is contraste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1ae9bcf16fbc485a85ff25d5fa3c47
https://www.mdpi.com/1422-0067/22/10/5171

Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair

Autor: Nahathai, Dukaew, Teruaki, Konishi, Kongthawat, Chairatvit, Narongchai, Autsavapromporn, Noppamas, Soonthornchareonnon, Ariyaphong, Wongnoppavich

Publikováno v: Oncology Research

Radiotherapy (RT) is an important treatment for non-small cell lung cancer (NSCLC). However, the major obstacles to successful RT include the low radiosensitivity of cancer cells and the restricted radiation dose, which is given without damaging norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a311fae4c230a25753ac3b18bd4ab15
https://pubmed.ncbi.nlm.nih.gov/31727206