Zobrazeno 1 - 10
of 22
pro vyhledávání: '"DNA demethylase activity"'
Publikováno v:
Sensors and Actuators B: Chemical. 244:885-890
We report an ultrasensitive electrogenerated chemiluminescence (ECL) biosening method for the detection of DNA demethylase activity based on the site-specific cleavage of the HpaII endonuclease in conjunction with signal amplification by a Thionin-Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119358825e4610181a6e4f806185a1bd
https://doi.org/10.1016/j.snb.2017.01.065
https://doi.org/10.1016/j.snb.2017.01.065
Autor:
Ulrike Schumann, Elizabeth S. Dennis, Neil A. Smith, Chengcheng Zhong, Anthony A. Millar, Ming-Bo Wang, Joanne M Lee, Jian-Kang Zhu
Publikováno v:
Epigenetics
DNA demethylases function in conjunction with DNA methyltransferases to modulate genomic DNA methylation levels in plants. The Arabidopsis genome contains four DNA demethylase genes, DEMETER (DME), REPRESSOR OF SILENCING 1 (ROS1) also known as DEMETE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85292bf7df13e6ae8d6de62877eb9c5
Autor:
Kai Chen, Zhongjie Sun
Publikováno v:
Aging Cell
Summary DNA methylation increases with age. The objective of this study was to investigate whether compound H, a potential activator of DNA demethylases, attenuates aging‐related arterial stiffness and hypertension. Aged mice (24–27 months) and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82c5aae8c7bc7327aa104cd62b45521
http://europepmc.org/articles/PMC6052484
http://europepmc.org/articles/PMC6052484
Autor:
Wenjun Li, Wenbin Zhang, Yuanyuan Li, Wanqing Hua, Wei Bai, Weiying Yu, Lili Zhang, Bo Pang, Changgui Kou
Publikováno v:
Clinical Laboratory. 64
BACKGROUND DNA demethylase is a crucial enzyme in the epigenetic modification and regulation mechanisms of gene transcription. Based on previous assertions that the pathophysiology of schizophrenia is associated with epigenetics, we aimed to explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a63b78bf3fb47b53cd6e6d2f60f4d24
https://doi.org/10.7754/clin.lab.2018.180127
https://doi.org/10.7754/clin.lab.2018.180127
Publikováno v:
Analytica chimica acta. 934
DNA demethylation and demethylase activity play important roles in DNA self-repair, and their detection is key to early diagnosis of fatal diseases. Herein, a facile electrochemical DNA (E-DNA) sensor was developed for the sensitive detection of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54af1c21e9604c127f0ca2b564168813
https://pubmed.ncbi.nlm.nih.gov/27506345
https://pubmed.ncbi.nlm.nih.gov/27506345
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13614-13619
Cortical GABAergic dysfunction, a hallmark of both schizophrenia (SZ) and bipolar (BP) disorder pathophysiologies may relate to the hypermethylation of GABAergic gene promoters (i.e., reelin and GAD67). Benefits elicited by a combination of atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbe6afa37bcc3e2941a49af90a29bf9
https://doi.org/10.1073/pnas.0805493105
https://doi.org/10.1073/pnas.0805493105
Publikováno v:
Journal of Neuroscience Research. 85:2006-2016
In previous studies, we documented increased citrullinated myelin basic protein (MBP) was present in MBP isolated from multiple sclerosis (MS) normal appearing white matter (NAWM). This increase was due to the myelin enzyme peptidyl argininedeiminase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d76f2e7f4f5787dfe06e57de494a4f6
https://doi.org/10.1002/jnr.21329
https://doi.org/10.1002/jnr.21329
Publikováno v:
Breast Cancer Research
Introduction MBD2, the gene encoding methyl-CpG-binding domain (MBD)2, is a major methylation related gene and functions as a transcriptional repressor that can specifically bind to the methylated regions of other genes. MBD2 may also mediate gene ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68d15edd3d8a3f5a32517758431198c
http://europepmc.org/articles/PMC1242141
http://europepmc.org/articles/PMC1242141
Publikováno v:
Analytica chimica acta. 869
We report on the development of a sensitive and selective deoxyribonucleic acid (DNA) demethylase (using MBD2 as an example) activity assay by coupling the fluorescence quenching of graphene oxide (GO) with the site-specific cleavage of HpaII endonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9c88b8ec37befd7f01231ece664ccd
https://pubmed.ncbi.nlm.nih.gov/25818142
https://pubmed.ncbi.nlm.nih.gov/25818142
Publikováno v:
Analytica chimica acta. 840
A novel electrochemical method is developed for detection of DNA demethylation and assay of DNA demethylase activity. This method is constructed by hybridizing the probe with biotin tagged hemi-methylated complementary DNA and further capturing strep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83ee35ae80bbe3424afa0e78284e956
https://pubmed.ncbi.nlm.nih.gov/25086890
https://pubmed.ncbi.nlm.nih.gov/25086890