Zobrazeno 1 - 10
of 1 297
pro vyhledávání: '"DNA damaging"'
Autor:
Andrea Herencia-Ropero, Alba Llop-Guevara, Anna D. Staniszewska, Joanna Domènech-Vivó, Eduardo García-Galea, Alejandro Moles-Fernández, Flaminia Pedretti, Heura Domènech, Olga Rodríguez, Marta Guzmán, Enrique J. Arenas, Helena Verdaguer, Fernando J. Calero-Nieto, Sara Talbot, Luis Tobalina, Elisabetta Leo, Alan Lau, Paolo Nuciforo, Rodrigo Dienstmann, Teresa Macarulla, Joaquín Arribas, Orland Díez, Sara Gutiérrez-Enríquez, Josep V. Forment, Mark J. O’Connor, Mark Albertella, Judith Balmaña, Violeta Serra
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Poly (ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitors (PARPi) are targeted therapies approved for homologous recombination repair (HRR)-deficient breast, ovarian, pancreatic, and prostate cancers. Since inhibition of PARP1 is
Externí odkaz:
https://doaj.org/article/68b3f150f248467b98d10c77d2ec9d7a
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Chemoresistance is associated with tumor relapse and unfavorable prognosis. Multiple mechanisms underlying chemoresistance have been elucidated, including stemness and DNA damage repair. Here, the involvement of the WNT receptor,
Externí odkaz:
https://doaj.org/article/9b835cc8702a47cab6fcea3b5d9b335a
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
Rad6 functions as a ubiquitin-conjugating protein that regulates cellular processes in many fungal species. However, its role in filamentous entomopathogenic fungi remains poorly understood. This study characterizes Rad6 in Beauveria bassiana, a fila
Externí odkaz:
https://doaj.org/article/d22a6d5b94a142ea97c0e07c3311c716
Autor:
Mei Zhou, Limin Duan, Jiangbin Chen, Yumei Li, Zhengrong Yin, Siwei Song, Yaqi Cao, Ping Luo, Fan Hu, Guanghai Yang, Juanjuan Xu, Tingting Liao, Yang Jin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-29 (2024)
Abstract Background Malignant tumours seriously threaten human life and health, and effective treatments for cancer are still being explored. The ability of SHC SH2 domain-binding protein 1 (SHCBP1) to induce cell cycle disturbance and inhibit tumour
Externí odkaz:
https://doaj.org/article/ef77ede7b72c4464886802f6eaf66bc8
Autor:
Dong Hyun Lee, Muhammad Imran, Jae Ho Choi, Yoo Jung Park, Young Hwa Kim, Sunwoo Min, Tae Jun Park, Yong Won Choi
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 216-232 (2024)
Since therapy‐induced senescence (TIS) can either support or inhibit cancer progression, identifying which types of chemotherapeutic agents can produce the strongest anti‐tumor TIS is an important issue. Here, cyclin‐dependent kinase4/6 inhibit
Externí odkaz:
https://doaj.org/article/efb286e16a534a90ae9d08637f264779
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 10, Pp 4025-4059 (2023)
Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing, show great clinical therapeutic value. The ADCs’ payloads play a key role in determining the effica
Externí odkaz:
https://doaj.org/article/01e1f93a98334dec8f6a771a043d5d3b
Autor:
Todorovic Vesna, Groselj Blaz, Cemazar Maja, Prevc Ajda, Zakelj Martina Niksic, Strojan Primoz, Sersa Gregor
Publikováno v:
Radiology and Oncology, Vol 56, Iss 2, Pp 173-184 (2022)
Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging a
Externí odkaz:
https://doaj.org/article/cc01565e70bb4fc192a41b9b2df028b8
Autor:
Xin Peng, Shaolu Zhang, Yingying Wang, Zhicheng Zhou, Zixiang Yu, Zhenxing Zhong, Liang Zhang, Zhe‐Sheng Chen, Francois X. Claret, Moshe Elkabets, Feng Wang, Fan Sun, Ran Wang, Han Liang, Hou‐Wen Lin, Dexin Kong
Publikováno v:
Advanced Science, Vol 10, Iss 3, Pp n/a-n/a (2023)
Abstract Glioblastoma (GBM) is the most aggressive type of cancer. Its current first‐line postsurgery regimens are radiotherapy and temozolomide (TMZ) chemotherapy, both of which are DNA damage‐inducing therapies but show very limited efficacy an
Externí odkaz:
https://doaj.org/article/4f5319a95b1f4014976c1ba1ab1fe669
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.