Zobrazeno 1 - 10
of 159
pro vyhledávání: '"DNA break repair"'
Autor:
Foon Wu-Baer, Madeline Wong, Lydia Tschoe, Chyuan-Sheng Lin, Wenxia Jiang, Shan Zha, Richard Baer
Publikováno v:
Cells, Vol 12, Iss 23, p 2762 (2023)
Homology-directed repair (HDR) of double-strand DNA breaks (DSBs) is dependent on enzymatic resection of DNA ends by the Mre11/Rad50/Nbs1 complex. DNA resection is triggered by the CtIP/Sae2 protein, which allosterically promotes Mre11-mediated endon
Externí odkaz:
https://doaj.org/article/c46c1a5ffbd044fd934042040320e8b2
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15907 (2023)
Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability. Defects in the DNA damage response pathways can give rise to v
Externí odkaz:
https://doaj.org/article/e7f11a81046f47edbc61e8e855d5b8a8
Autor:
Martin Wilkinson, Oliver J Wilkinson, Connie Feyerherm, Emma E Fletcher, Dale B Wigley, Mark S Dillingham
Publikováno v:
eLife, Vol 11 (2022)
Following infection of bacterial cells, bacteriophage modulate double-stranded DNA break repair pathways to protect themselves from host immunity systems and prioritise their own recombinases. Here, we present biochemical and structural analysis of t
Externí odkaz:
https://doaj.org/article/deed9afa353444d1ae21096d30bb3ffc
Autor:
Rogelio Hernández-Tamayo, Niklas Steube, Thomas Heimerl, Georg K. A. Hochberg, Peter L. Graumann
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT RecA plays a central role in DNA repair and is a main actor involved in homologous recombination (HR). In vivo, RecA forms filamentous structures termed “threads,” which are essential for HR, but whose nature is still ill defined. We sho
Externí odkaz:
https://doaj.org/article/946770b493494bbbb282a2a1360da27f
Autor:
Catalina Pereira, Gerardo A Arroyo-Martinez, Matthew Z Guo, Michael S Downey, Emma R Kelly, Kathryn J Grive, Shantha K Mahadevaiah, Jennie R Sims, Vitor M Faca, Charlton Tsai, Carl J Schiltz, Niek Wit, Heinz Jacobs, Nathan L Clark, Raimundo Freire, James Turner, Amy M Lyndaker, Miguel A Brieno-Enriquez, Paula E Cohen, Marcus B Smolka, Robert S Weiss
Publikováno v:
eLife, Vol 11 (2022)
DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an
Externí odkaz:
https://doaj.org/article/57deb83a4c11495681d45121899c60e3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Wen-Wei Zhang, Greg Matlashewski
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT CRISPR-Cas9 genome editing relies on an efficient double-strand DNA break (DSB) and repair. Contrary to mammalian cells, the protozoan parasite Leishmania lacks the most efficient nonhomologous end-joining pathway and uses microhomology-medi
Externí odkaz:
https://doaj.org/article/6a04c6b29f2849d5825dd05b8dcbe129
Autor:
Oliver J Wilkinson, Alejandro Martín-González, Haejoo Kang, Sarah J Northall, Dale B Wigley, Fernando Moreno-Herrero, Mark Simon Dillingham
Publikováno v:
eLife, Vol 8 (2019)
CtIP is involved in the resection of broken DNA during the S and G2 phases of the cell cycle for repair by recombination. Acting with the MRN complex, it plays a particularly important role in handling complex DNA end structures by localised nucleoly
Externí odkaz:
https://doaj.org/article/990f52da8a4c4714a3896f10d6bc2499