Zobrazeno 1 - 10
of 5 364
pro vyhledávání: '"DNA adduct"'
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38610- (2024)
In the body, ethanol is metabolized to acetaldehyde by alcohol dehydrogenase and CYP2E1. Acetaldehyde is the main carcinogen that forms DNA adducts, N2-Ethylidene-2'-deoxyguanosine (N2-Ethylidene-dG), which can cause DNA damage and lead to cancer. Ho
Externí odkaz:
https://doaj.org/article/df0ffc11ee7846a1a7bf7e64407e0383
Autor:
Ling Guo, Xuewei Zhang, Xinwei Li, Kai Wang, Yanhua Wang, Alimire Abulikemu, Xizi Su, Mushui Shu, Haibin Li, Shiwei Cui, Zhizhen Xu, Haoyuan Tian, Yong Niu, Huige Yuan, Zhizhou He, Xin Sun, Huawei Duan
Publikováno v:
Environment International, Vol 190, Iss , Pp 108922- (2024)
Background: Benzo(a)pyrene (B[a]P) is the most widely concerned polycyclic aromatic hydrocarbons (PAHs), which metabolizes benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) in vivo to produce carcinogenic effect on the body. Currently, there is limi
Externí odkaz:
https://doaj.org/article/5106da60d6f344bd998834f1b5a7ba4f
Publikováno v:
环境与职业医学, Vol 41, Iss 3, Pp 323-329 (2024)
BackgroundThe active metabolite of benzo[a]pyrene (BaP), 7,8-dihydroxy-9,10-epoxybenzo[a]pyrene (BPDE), can form adducts with DNA, but the spectrum of BPDE-DNA adducts is unclear. ObjectiveTo identify the distribution of BPDE adduct sites and associa
Externí odkaz:
https://doaj.org/article/c2aee5bc4ee14c80bef019b0d55329c0
Autor:
Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye
Publikováno v:
Bioactive Materials, Vol 23, Iss , Pp 45-52 (2023)
Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severel
Externí odkaz:
https://doaj.org/article/c947b65c845a4b388c47f5e1e9ed973d
Autor:
Valeria Guidolin, Yupeng Li, Foster C. Jacobs, Margaret L. MacMillan, Peter W. Villalta, Stephen S. Hecht, Silvia Balbo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 197-210 (2023)
DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The establishment of predictive biomarkers to identify patients who will effectively respond to treatment would allow for the development of personalized therapies. As
Externí odkaz:
https://doaj.org/article/f315c051a02546108a41e33146bf52da
Publikováno v:
DNA, Vol 3, Iss 1, Pp 13-32 (2023)
Both the number of cells and the collective genome of the gut microbiota outnumber their mammalian hosts, and the metabolic and physiological interactions of the gut microbiota with the host have not yet been fully characterized. Cancer remains one o
Externí odkaz:
https://doaj.org/article/63fded8dc4e54330bc8c9421e84af190
Autor:
Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang, Wentao Li
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a cisplatin loading nanomotor based
Externí odkaz:
https://doaj.org/article/ce3c1a95094943a4bb22a25858dd19f0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.