Zobrazeno 1 - 10
of 116
pro vyhledávání: '"DNA accessibility"'
Autor:
Alexey V. Onufriev
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Stability of a protein-ligand complex may be sensitive to pH of its environment. Here we explore, computationally, stability of a set of protein-nucleic acid complexes using fundamental thermodynamic linkage relationship. The nucleosome, as well as a
Externí odkaz:
https://doaj.org/article/f91d061b81064f9ebe46e7cb3e9cc25a
Autor:
Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer
Publikováno v:
eLife, Vol 9 (2020)
The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitiv
Externí odkaz:
https://doaj.org/article/d33cd1744564400abf93c1226f3c6a09
Autor:
Huimin Xie, Hanne M. Hoffmann, Anita K. Iyer, Melissa J. Brayman, Cindy Ngo, Mary Jean Sunshine, Pamela L. Mellon
Publikováno v:
Reproductive Biology and Endocrinology, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background Proper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development
Externí odkaz:
https://doaj.org/article/561860d91a1a47f494c318fe109167e5
Autor:
Orly L. Wapinski, Qian Yi Lee, Albert C. Chen, Rui Li, M. Ryan Corces, Cheen Euong Ang, Barbara Treutlein, Chaomei Xiang, Valérie Baubet, Fabian Patrik Suchy, Venkat Sankar, Sopheak Sim, Stephen R. Quake, Nadia Dahmane, Marius Wernig, Howard Y. Chang
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3236-3247 (2017)
How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here, we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout conversion of fibroblasts into induced neuronal (iN) cells. Thousands
Externí odkaz:
https://doaj.org/article/f94ed8fb92644ec5875519ed63f8a4eb
Autor:
Teddy Jégu, Alaguraj Veluchamy, Juan S. Ramirez-Prado, Charley Rizzi-Paillet, Magalie Perez, Anaïs Lhomme, David Latrasse, Emeline Coleno, Serge Vicaire, Stéphanie Legras, Bernard Jost, Martin Rougée, Fredy Barneche, Catherine Bergounioux, Martin Crespi, Magdy M. Mahfouz, Heribert Hirt, Cécile Raynaud, Moussa Benhamed
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Plant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on
Externí odkaz:
https://doaj.org/article/1298cda180d841b38327c81bee329e93
Autor:
Giovannangeli, Carine, Diviacco, Silvia, Labrousse, Valérie, Gryaznov, Sergei, Charneau, Pierre, Helene, Claude
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1997 Jan 01. 94(1), 79-84.
Externí odkaz:
https://www.jstor.org/stable/41451
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism betwee
Externí odkaz:
https://doaj.org/article/ae8da98a4f1448ac9ee0454866b2ea20
Autor:
Irwin D. Bernstein, Wouter Meuleman, Suzanne Furuyama, Richard Sandstrom, Qian 'Vicky' Wu, Barbara Varnum-Finney, John A. Stamatoyannopoulos
Publikováno v:
Stem Cell Reports
Summary T cell development is restricted to the thymus and is dependent on high levels of Notch signaling induced within the thymic microenvironment. To understand Notch function in thymic restriction, we investigated the basis for target gene select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579374c8bd34b3aae7694b8ba064812e
http://europepmc.org/articles/PMC8072033
http://europepmc.org/articles/PMC8072033
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
ZANDIAN, MOHAMADSADEGH
Chromatin is a protein-DNA complex. It compacts the eukaryotic genome by a factor of ~10,000 times to confine the genome in the cell nuclei. Additionally, chromatin regulates the function of the genome, such as replication, transcription, and repair,
