Zobrazeno 1 - 10
of 20
pro vyhledávání: '"DNA Topoisomerase I Inhibitors"'
Autor:
Yuki Abe, Takahiro Jikoh, Toshinori Agatsuma, Gilles J. A. Gallant, Kiyoshi Sugihara, Javad Shahidi, Takashi Nakada
Publikováno v:
Cancer Drug Delivery Systems Based on the Tumor Microenvironment ISBN: 9784431568780
Antibody–drug conjugates (ADCs) represent a promising class of drugs with a wider therapeutic index (TI) than conventional chemotherapeutic agents due to their efficient and specific drug delivery. ADC payload is attached to antibody by chemical li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0c26a68d7aa028542a250834985cf76
https://doi.org/10.1007/978-4-431-56880-3_7
https://doi.org/10.1007/978-4-431-56880-3_7
Autor:
Zhong-Long Guo, Ya-Chu Fan, Hua-Shi Guan, Lan-Ting Xin, Shi-Jun Yue, Chang-Yun Wang, Rilei Yu, Mei Wang, Fangling Chen, Lu Liu, Chang-Lun Shao
Publikováno v:
Marine Drugs
Volume 15
Issue 7
Pages: 217
Marine Drugs, Vol 15, Iss 7, p 217 (2017)
Volume 15
Issue 7
Pages: 217
Marine Drugs, Vol 15, Iss 7, p 217 (2017)
Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe toxic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f1cead7875556f0c53fc0d5db7f2e9
Autor:
Pan-Pan Li, Hai-Yang Liu, Lin-Kun An, Xiao-Jiang Hao, Xu-Jie Qin, Huan Yan, Qian Yu, Mi-Yan Feng, Afsar Khan
Publikováno v:
Journal of agricultural and food chemistry. 65(24)
Psidium guajava L., a species native to South America, has been widely cultivated in the tropical and subtropical areas of China for its popular fruits. The preliminary analysis by liquid chromatography-ultraviolet (LC-UV) indicated the presence of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5771b85a16da67e147dd35dea8bd735e
https://pubmed.ncbi.nlm.nih.gov/28578580
https://pubmed.ncbi.nlm.nih.gov/28578580
Publikováno v:
Current Topics in Medicinal Chemistry. 3:305-320
Human DNA topoisomerase I is the target of camptothecins, which have been recently introduced in the clinic for cancer chemotherapy. The discovery of novel non-camptothecin inhibitors is facilitated by the availability of biochemical and cellular ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aeedf518fa3f470fc0e78375ede6fa7
https://doi.org/10.2174/1568026033452546
https://doi.org/10.2174/1568026033452546
Autor:
Wannian Zhang, et al. et al.
Publikováno v:
ChemInform. 45
Novel homocamptothecin analogs with acylamino groups at C-9 (III) are synthesized and screened for their cytotoxic activities against three cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fcd4f6a79ef131ebe61a93f5dcb3be
https://doi.org/10.1002/chin.201409208
https://doi.org/10.1002/chin.201409208
Publikováno v:
Tetrahedron. 54:15701-15710
Topostins B567 (2b) and D654 (3b) (WB-3559D, flavolipin) have been efficiently synthesized from 1, 10-decanediol (5) in 11 and 13 steps, respectively, involving an asymmetric hydrogenation of the β-keto ester14 using(R)-BINAP ruthenium bromide and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65fe37f8ecf230fcf504b521685f1d0
https://doi.org/10.1016/s0040-4020(98)00984-3
https://doi.org/10.1016/s0040-4020(98)00984-3
Publikováno v:
Tetrahedron. 54:2683-2690
The structures of topostins, a novel type of mammalian DNA topoisomerase I inhibitors isolated from the bacterium Flexibacter topostinus sp. nov., have remained unknown. Reexamination of the production of topostins resulted in the isolation of origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d6c14f4a243c713c436bb2633962d8
https://doi.org/10.1016/s0040-4020(98)83004-4
https://doi.org/10.1016/s0040-4020(98)83004-4
Publikováno v:
Tetrahedron Letters. 38:5667-5670
Amphimic acids A ( 1 ) and B ( 2 ), novel unsaturated long-chain fatty acids possessing a cyclopropylidene group and inhibiting DNA topoisomerase I, have been isolated from an Australian sponge Amphimedon sp. Their structures were elucidated by spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0202e20cf4039b033d98d70c1d79f071
https://doi.org/10.1016/s0040-4039(97)01234-3
https://doi.org/10.1016/s0040-4039(97)01234-3
Publikováno v:
Tetrahedron Letters. 38:4235-4238
Two ceramide 1-sulfates 1 and 2 have been isolated from the Japanese Bryozoa Watersipora cucullata as new potent inhibitors of a human DNA topoisomerase I. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their absolute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84a2581c9b0012eb23d3f6a910897967
https://doi.org/10.1016/s0040-4039(97)00852-6
https://doi.org/10.1016/s0040-4039(97)00852-6
Publikováno v:
Drugs of the Future. 41:731
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee308b2b1c4175d95fa75f4829fbc28f
https://doi.org/10.1358/dof.2016.041.12.2563475
https://doi.org/10.1358/dof.2016.041.12.2563475