Zobrazeno 1 - 10
of 5 997
pro vyhledávání: '"DNA Supercoil"'
Publikováno v:
ALIFE 2021: The 2021 Conference on Artificial Life
ALIFE 2021-Conference on Artificial Life
ALIFE 2021-Conference on Artificial Life, Jul 2021, Prague, Czech Republic
ALIFE 2021: The 2021 Conference on Artificial Life, Jul 2021, Prague, Czech Republic
Artificial Life
Artificial Life, 2022, ⟨10.1162/artl_a_00373⟩
HAL
ALIFE 2021-Conference on Artificial Life
ALIFE 2021-Conference on Artificial Life, Jul 2021, Prague, Czech Republic
ALIFE 2021: The 2021 Conference on Artificial Life, Jul 2021, Prague, Czech Republic
Artificial Life
Artificial Life, 2022, ⟨10.1162/artl_a_00373⟩
HAL
DNA supercoiling, the level of under- or overwinding of the DNA polymer around itself, is widely recognized as an ancestral regulation mechanism of gene expression in bacteria. Higher levels of negative supercoiling facilitate the opening of the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafc42787f83aefdb653a28f601f0d92
https://doi.org/10.1162/artl_a_00373
https://doi.org/10.1162/artl_a_00373
Autor:
Sung Hyun Kim, Mahipal Ganji, Eugene Kim, Jaco van der Torre, Elio Abbondanzieri, Cees Dekker
Publikováno v:
eLife, Vol 7 (2018)
The three-dimensional organization of DNA is increasingly understood to play a decisive role in vital cellular processes. Many studies focus on the role of DNA-packaging proteins, crowding, and confinement in arranging chromatin, but structural infor
Externí odkaz:
https://doaj.org/article/dfb615d3e2d54b08900e241d48082528
Publikováno v:
Nucleic Acids Research
G-quadruplex is an essential element in gene transcription that serves as a promising drug target. Guanine-vacancy-bearing G-quadruplex (GVBQ) is a newly identified G-quadruplex that has distinct structural features from the canonical G-quadruplex. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5608f6e16b0b47b8e5785945ec591f
https://doi.org/10.1093/nar/gkab1154
https://doi.org/10.1093/nar/gkab1154
Autor:
Jacques Oberto, Ryan J. Catchpole, Tamara Basta, Patrick Forterre, Etienne Villain, Paul Villain, Violette Da Cunha
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2021, 49 (21), pp.12332-12347. ⟨10.1093/nar/gkab869⟩
Nucleic Acids Research, 2021, 49 (21), pp.12332-12347. ⟨10.1093/nar/gkab869⟩
In all cells, DNA topoisomerases dynamically regulate DNA supercoiling allowing essential DNA processes such as transcription and replication to occur. How this complex system emerged in the course of evolution is poorly understood. Intriguingly, a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da6136b2c90ce6081239e1325b43e47
https://doi.org/10.1093/nar/gkab869
https://doi.org/10.1093/nar/gkab869
Publikováno v:
Nucleic Acids Research
Protein-mediated DNA looping is fundamental to gene regulation and such loops occur stochastically in purified systems. Additional proteins increase the probability of looping, but these probabilities maintain a broad distribution. For example, the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea92dccd6bcd560ebcb02711ab2ecae
http://europepmc.org/articles/PMC8599721
http://europepmc.org/articles/PMC8599721
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:713-720
The topology of DNA is a critical quality attribute for plasmid-based pharmaceuticals, making quantification of trace levels of plasmid topoisomers an important analytical priority. An automated and cost-effective method based on capillary gel electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f384909fef2a3160f8844a25abc9bd10
https://doi.org/10.1007/s00216-021-03714-9
https://doi.org/10.1007/s00216-021-03714-9
Publikováno v:
Molecular Pharmacology. 101:24-32
DNA topoisomerases regulate the topological state of DNA, relaxing DNA supercoils and resolving catenanes and knots that result from biologic processes, such as transcription and replication. DNA topoisomerase II (TOP2) enzymes achieve this by bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08706aa4c4ba337d838a130e93b1bfc
https://doi.org/10.1124/molpharm.121.000374
https://doi.org/10.1124/molpharm.121.000374
Publikováno v:
Journal of the American Chemical Society. 143:16734-16739
Despite the frequent occurrence of knotted frameworks in protein structures, the latent potential of peptide strands to form entangled structures is rarely discussed in peptide chemistry. Here we report the construction of highly entangled molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7d39097f2f5b5e16bd09e146e69302
https://doi.org/10.1021/jacs.1c08094
https://doi.org/10.1021/jacs.1c08094
Autor:
Kentaro Koide, Yuki Ouchi, Lai Lai San, Chie Nakajima, Ruttana Pachanon, Yasuhiko Suzuki, Siriporn Kongsoi, Fuangfa Utrarachkij, Jong-Hoon Park
Publikováno v:
Microbial Drug Resistance. 27:1397-1404
Aims: Quinolone-resistant nontyphoidal Salmonella having serine replaced by isoleucine at the 83rd amino acid in GyrA (GyrA-Ser83Ile) has recently been found in Asian countries. In this study, we aimed to examine the direct effect of substitution Ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072b60f47379deb023fbe84015c18c67
https://doi.org/10.1089/mdr.2020.0437
https://doi.org/10.1089/mdr.2020.0437
Autor:
Valeria Cassina, Matteo Cristofalo, Claudia Adriana Marrano, Laura Finzi, Qing Shao, Francesco Mantegazza, Domenico Salerno, David Dunlap
Publikováno v:
Nucleic Acids Research
Single molecule experiments have demonstrated a progressive transition from a B- to an L-form helix as DNA is gently stretched and progressively unwound. The particular sequence of a DNA segment defines both base stacking and hydrogen bonding that af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518a7144d325c49e4ecb2ece3cb9832d
http://europepmc.org/articles/PMC8599871
http://europepmc.org/articles/PMC8599871