Zobrazeno 1 - 10
of 635
pro vyhledávání: '"DNA Replication Fork"'
Autor:
Sandhya Balasubramanian, Matteo Andreani, Júlia Goncalves Andrade, Tannishtha Saha, Devakumar Sundaravinayagam, Javier Garzón, Wenzhu Zhang, Oliver Popp, Shin-ichiro Hiraga, Ali Rahjouei, Daniel B Rosen, Philipp Mertins, Brian T Chait, Anne D Donaldson, Michela Di Virgilio
Publikováno v:
eLife, Vol 11 (2022)
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular de
Externí odkaz:
https://doaj.org/article/9aa8a2536f2d4d70bc4fcafdfdb0c33a
Autor:
Hidenori Nakaoka, Masahiro Takikawa, Junko Kanoh, Sanki Tashiro, Tomoichiro Miyoshi, Io Yamamoto, Fuyuki Ishikawa
Publikováno v:
Nucleic Acids Research
Telomere binding protein Stn1 forms the CST (Cdc13/CTC1-STN1-TEN1) complex in budding yeast and mammals. Likewise, fission yeast Stn1 and Ten1 form a complex indispensable for telomere protection. We have previously reported that stn1-1, a high-tempe
Autor:
Senkevich, Tatiana G., Bruno, Daniel, Martens, Craig, Porcella, Stephen F., Wolf, Yuri I., Moss, Bernard
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2015 Sep 01. 112(35), 10908-10913.
Externí odkaz:
https://www.jstor.org/stable/26464090
Autor:
Piero R. Bianco
Publikováno v:
Genes, Vol 11, Iss 5, p 471 (2020)
In Escherichia coli, DNA replication forks stall on average once per cell cycle. When this occurs, replisome components disengage from the DNA, exposing an intact, or nearly intact fork. Consequently, the fork structure must be regressed away from th
Externí odkaz:
https://doaj.org/article/89bbda2157064e2684bc24fafed6b395
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Hexameric helicases are motor proteins that unwind double-stranded DNA (dsDNA) during DNA replication but how they are optimised for strand separation is unclear. Here we present the cryo-EM structure of the full-length E1 helicase from papillomaviru
Publikováno v:
Nucleic Acids Research
The Bloom syndrome DNA helicase BLM contributes to chromosome stability through its roles in double-strand break repair by homologous recombination and DNA replication fork restart during the replication stress response. Loss of BLM activity leads to
Autor:
N. Patrick J. Stamford, Slobodan Jergic, Nicholas E. Dixon, Lisanne M. Spenkelink, Antoine M. van Oijen, Richard R. Spinks, Susan E. Brown, Sarah A. Stratmann, Zhi-Qiang Xu
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 49(12), 6804-6816. Oxford University Press
Nucleic Acids Research, 49(12), 6804-6816. Oxford University Press
In Escherichia coli, the DnaB helicase forms the basis for the assembly of the DNA replication complex. The stability of DnaB at the replication fork is likely important for successful replication initiation and progression. Single-molecule experimen
Autor:
Caiyong Lai, Guo Chen, Yan Chen, Naite Xi, Ling Tian, Mingrong Cao, Yongchang Zhang, Qi Feng, Congcong Chen, Shengbin Lin, Yanguan Guo, Li Yu, Jiaxin Tian, Jinye Mi, Jun Fan, Fan Zhang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 643-652 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Ribonucleotide reductase (RNR) is the key enzyme that catalyzes the production of deoxyribonucleotides (dNTPs) for DNA replication and it is also essential for cancer cell proliferation. As the RNR inhibitor, Gemcitabine is widely used in cancer ther
Publikováno v:
Current Genetics
The disease-associated nuclease–helicase DNA2 has been implicated in DNA end-resection during DNA double-strand break repair, Okazaki fragment processing, and the recovery of stalled DNA replication forks (RFs). Its role in Okazaki fragment process
Autor:
Tanay Thakar, George Lucian Moldovan
Publikováno v:
Nucleic Acids Research
A universal response to replication stress is replication fork reversal, where the nascent complementary DNA strands are annealed to form a protective four-way junction allowing forks to avert DNA damage while replication stress is resolved. However,