Alterations in homologous recombination repair genes in prostate cancer brain metastases

Autor: Antonio Rodriguez-Calero, John Gallon, Dilara Akhoundova, Sina Maletti, Alison Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Erik Vassella, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Charlotte K. Y. Ng, Silke Gillessen, Salvatore Piscuoglio, Mark A. Rubin

Publikováno v: Nature communications, vol. 13, no. 1, pp. 2400
Rodriguez-Calero, Antonio; Gallon, John; Akhoundova, Dilara; Maletti, Sina; Ferguson, Alison; Cyrta, Joanna; Amstutz, Ursula; Garofoli, Andrea; Paradiso, Viola; Tomlins, Scott A; Hewer, Ekkehard; Genitsch, Vera; Fleischmann, Achim; Vassella, Erik; Rushing, Elisabeth J; Grobholz, Rainer; Fischer, Ingeborg; Jochum, Wolfram; Cathomas, Gieri; Osunkoya, Adeboye O; ... (2022). Alterations in homologous recombination repair genes in prostate cancer brain metastases. Nature Communications, 13(1), p. 2400. Springer Nature 10.1038/s41467-022-30003-5

Improved survival rates for prostate cancer through more effective therapies have also led to an increase in the diagnosis of metastases to infrequent locations such as the brain. Here we investigate the repertoire of somatic genetic alterations pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d339acb753118a030885e55b80a56cbb
https://www.zora.uzh.ch/id/eprint/222097/

The evolutionary history of 2,658 cancers

Autor: Gerstung, M., Jolly, C., Leshchiner, I., Dentro, S.C., Gonzalez, S., Rosebrock, D., Mitchell, T.J., Rubanova, Y., Anur, P., Yu, K., Tarabichi, M., Deshwar, A.G., Wintersinger, J., Kleinheinz, K., Vázquez-García, I., Haase, K., Jerman, L., Sengupta, Subhajit, Macintyre, G., Malikic, S., Donmez, N., Livitz, D.G., Cmero, M., Demeulemeester, J., Schumacher, S., Fan, Y., Yao, X., Lee, J., Schlesner, M., Boutros, P.C., Bowtell, D.D., Zhu, H., Getz, G., Imielinski, M., Beroukhim, R., Sahinalp, S.C., Ji, Y., Peifer, M., Markowetz, F., Mustonen, V., Yuan, K., Wang, W., Morris, Q.D., Adams, D.J., Campbell, P.J., Cao, S., Christie, E.L., Cun, Y., Dawson, K.J., Drews, R.M., Eils, R., Fittall, M., Garsed, D.W., Ha, G., Lee-Six, H., Martincorena, I., Oesper, L., Peto, M., Raphael, B.J., Salcedo, A., Sengupta, S., Shi, R., Shin, S.J., Spiro, O., Stein, L.D., Vembu, S., Wheeler, D.A., Yang, T.-P., Spellman, P.T., Wedge, D.C., Van Loo, P.

Publikováno v: Nature, vol 578, iss 7793
Nature, 578, 122-128
Nature
Nature, 578, 7793, pp. 122-128
Gerstung, M, Jolly, C, Leshchiner, I, Dentro, S C, Gonzalez, S, Rosebrock, D, Mitchell, T J, Rubanova, Y, Anur, P, Yu, K, Tarabichi, M, Deshwar, A G, Wintersinger, J, Kleinheinz, K, Vázquez-García, I, Haase, K, Jerman, L, Sengupta, S, Macintyre, G, Malikic, S, Donmez, N, Livitz, D G, Cmero, M, Demeulemeester, J, Schumacher, S, Fan, Y, Yao, X, Lee, J, Schlesner, M, Boutros, P C, Bowtell, D D, Zhu, H, Getz, G, Imielinski, M, Beroukhim, R, Sahinalp, S C, Ji, Y, Peifer, M, Markowetz, F, Mustonen, V, Yuan, K, Wang, W, Morris, Q D, Dentro, S C, Leshchiner, I, Gerstung, M, Jolly, C, Haase, K, Tarabichi, M, Wintersinger, J, Deshwar, A G, Yu, K, Gonzalez, S, Rubanova, Y, Macintyre, G, Adams, D J, Anur, P, Beroukhim, R, Boutros, P C, Bowtell, D D, Campbell, P J, Cao, S, Christie, E L, Cmero, M, Cun, Y, Dawson, K J, Donmez, N, Drews, R M, Eils, R, Fan, Y, Fittall, M, Garsed, D W, Getz, G, Ha, G, Imielinski, M, Jerman, L, Ji, Y, Kleinheinz, K, Lee, J, Lee-Six, H, Livitz, D G, Malikic, S, Markowetz, F, Martincorena, I, Mitchell, T J, Mustonen, V, Oesper, L, Peifer, M, Peto, M, Raphael, B J, Rosebrock, D, Sahinalp, S C, Salcedo, A, Schlesner, M, Schumacher, S, Sengupta, S, Shi, R, Shin, S J, Spiro, O, Stein, L D, Vázquez-García, I, Vembu, S, Wheeler, D A, Yang, T-P, Yao, X, Yuan, K, Zhu, H, Wang, W, Morris, Q D, Spellman, P T, Wedge, D C, Van Loo, P, Spellman, P T & Wedge, D C 2020, ' The evolutionary history of 2,658 cancers ', Nature, vol. 578, no. 7793, pp. 122-128 . https://doi.org/10.1038/s41586-019-1907-7

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a891fdaa058cb17c6b08024ab762a118
https://hdl.handle.net/2066/288694

R-loops as Janus-faced modulators of DNA double-strand break repair

Autor: Marnef, Aline, Legube, Gaëlle

Publikováno v: Nature Cell Biology
Nature Cell Biology, 2021, 23 (4), pp.305-313. ⟨10.1038/s41556-021-00663-4⟩

International audience; R-loops are non-B DNA structures with intriguing dual consequences for gene expression and genome stability. In addition to their recognized roles in triggering DNA double-strand breaks (DSBs), R-loops have recently been demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3379::600c3cbdafca0981a335c4dbc466e917
https://ut3-toulouseinp.hal.science/hal-04125277

DNA repair in plant mitochondria - A complete base excision repair pathway in potato tuber mitochondria

Autor: Ana Luiza Dorigan de Matos Furlanetto, Kim H. Hebelstrup, Beatriz Ferrando, Jesper F. Havelund, Ian M. Møller, Tinna Stevnsner, Ricardo Gredilla

Publikováno v: Ferrando, B, de Matos Furlanetto, A L D, Gredilla, R, Havelund, J F, Hebelstrup, K H, Møller, I M & Stevnsner, T 2019, ' DNA repair in plant mitochondria-A complete base excision repair pathway in potato tuber mitochondria ', Physiologia Plantarum, vol. 166, no. 2, pp. 494-512 . https://doi.org/10.1111/ppl.12801
Ferrando, B, Furlanetto, A L D M, Gredilla, R, Havelund, J F, Hebelstrup, K H, Møller, I M & Stevnsner, T 2019, ' DNA repair in plant mitochondria - a complete base excision repair pathway in potato tuber mitochondria ', Physiologia Plantarum, vol. 166, no. 2, pp. 494-512 . https://doi.org/10.1111/ppl.12801

Mitochondria are one of the major sites of reactive oxygen species (ROS) production in the plant cell. ROS can damage DNA, and this damage is in many organisms mainly repaired by the base excision repair (BER) pathway. We know very little about DNA r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac9f6048af023512b92f47ba8349682
https://findresearcher.sdu.dk:8443/ws/files/143374912/DNA_repair_in_plant_mitochondria_A_complete_base_excision_repair_pathway_in_potato_tuber_mitochondria.pdf

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Autor: Martijn P. Lolkema, Harmen J.G. van de Werken, Paul C. Boutros, Andries M. Bergman, Takafumi N. Yamaguchi, Yanyun Zhu, Lisanne F. van Dessel, Job van Riet, Niven Mehra, Wilbert Zwart, Julie Livingstone, Neeltje Steeghs, Stefan Sleijfer, Ronald de Wit, Michiel S. van der Heijden, Minke Smits, Edwin Cuppen, Paul Hamberg, Emile E. Voest, John W.M. Martens, Inge M. van Oort

Publikováno v: Nature communications, 10(1):5251. Nature Publishing Group
Nature Communications, 10
Nature Communications, 10(1):5251. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 10(1). Nature Publishing Group
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications, 10:5251. Nature Publishing Group

Metastatic castration-resistant prostate cancer (mCRPC) has a highly complex genomic landscape. With the recent development of novel treatments, accurate stratification strategies are needed. Here we present the whole-genome sequencing (WGS) analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2882275e8ceb9ccb244ebae17d027bd1
https://pure.amc.nl/en/publications/the-genomic-landscape-of-metastatic-castrationresistant-prostate-cancers-reveals-multiple-distinct-genotypes-with-potential-clinical-impact(1c43a7d4-1537-4df6-99fc-d5fc23d2db5a).html