Zobrazeno 1 - 10
of 14
pro vyhledávání: '"DNA Methylation/drug effects"'
Autor:
Nikola Sobočan, Marta Himelreich-Perić, Ana Katušić-Bojanac, Jure Krasić, Nino Sinčić, Željka Majić, Gordana Jurić-Lekić, Ljiljana Šerman, Andreja Marić, Davor Ježek, Floriana Bulić-Jakuš
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 603
International Journal of Molecular Sciences, Vol 23, Iss 603, p 603 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 603, p 603 (2022)
International Journal of Molecular Sciences
Antioxidant N-tert-Butyl-α-phenylnitron (PBN) partly protected embryos from the negative effects of a DNA demethylating drug 5-azacytidine during pregnancy. Our aim was to investigate PBN’s impact on the placenta. Fischer rat dams were treated on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdb5992b1798da16989b4cf40783133
Autor:
Brian Thiessen, Olivier Chinot, Martin J B Taphoorn, Frédéric Dhermain, Jaap C. Reijneveld, Anja Gijtenbeek, Andreas von Deimling, Martin J. van den Bent, Roelien H. Enting, Elodie Vauleon, Alba A. Brandes, Monika E. Hegi, Sebastian Kurscheid, Pierre Bady, Brigitta G. Baumert, Mauro Delorenzi, Roger Stupp, Wolfgang Wick, Pim J. French, Thierry Gorlia, Khê Hoang-Xuan, Christine Marosi
Publikováno v:
Acta Neuropathologica, 135(4), 601-615
Acta Neuropathologica, 135, 4, pp. 601-615
Acta Neuropathologica, 135(4), 601-615. Springer Verlag
Acta Neuropathologica, 135, 601-615
Acta Neuropathologica, 135(4), 601-615. SPRINGER
Bady, P, Kurscheid, S, Delorenzi, M, Gorlia, T, van den Bent, M J, Hoang-Xuan, K, Vauléon, É, Gijtenbeek, A, Enting, R, Thiessen, B, Chinot, O, Dhermain, F, Brandes, A A, Reijneveld, J C, Marosi, C, Taphoorn, M J B, Wick, W, von Deimling, A, French, P, Stupp, R, Baumert, B G & Hegi, M E 2018, ' The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033 ', Acta Neuropathologica, vol. 135, no. 4, pp. 601-615 . https://doi.org/10.1007/s00401-018-1810-6
Acta Neuropathologica, 135(4), 601-615. Springer, Cham
Acta neuropathologica, vol. 135, no. 4, pp. 601-615
Acta Neuropathologica, 135(4), 601-615. Springer-Verlag
Acta Neuropathologica, 135, 4, pp. 601-615
Acta Neuropathologica, 135(4), 601-615. Springer Verlag
Acta Neuropathologica, 135, 601-615
Acta Neuropathologica, 135(4), 601-615. SPRINGER
Bady, P, Kurscheid, S, Delorenzi, M, Gorlia, T, van den Bent, M J, Hoang-Xuan, K, Vauléon, É, Gijtenbeek, A, Enting, R, Thiessen, B, Chinot, O, Dhermain, F, Brandes, A A, Reijneveld, J C, Marosi, C, Taphoorn, M J B, Wick, W, von Deimling, A, French, P, Stupp, R, Baumert, B G & Hegi, M E 2018, ' The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033 ', Acta Neuropathologica, vol. 135, no. 4, pp. 601-615 . https://doi.org/10.1007/s00401-018-1810-6
Acta Neuropathologica, 135(4), 601-615. Springer, Cham
Acta neuropathologica, vol. 135, no. 4, pp. 601-615
Acta Neuropathologica, 135(4), 601-615. Springer-Verlag
The optimal treatment for patients with low-grade glioma (LGG) WHO grade II remains controversial. Overall survival ranges from 2 to over 15 years depending on molecular and clinical factors. Hence, risk-adjusted treatments are required for optimizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422a15982be72bdd3ae70ac6b3775603
https://hdl.handle.net/2066/190470
https://hdl.handle.net/2066/190470
Publikováno v:
Meehan, R R, Thomson, J P, Lentini, A, Nestor, C E & Pennings, S 2018, ' DNA methylation as a genomic marker of exposure to chemical and environmental agents ', Current opinion in chemical biology, vol. 45, pp. 48-56 . https://doi.org/10.1016/j.cbpa.2018.02.006, https://doi.org/10.1016/j.cbpa.2018.02.006
Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::45836cc5c55b3f46287af38bf5303e70
https://hdl.handle.net/20.500.11820/08848b9f-c202-4ce6-8ed6-4cf1474e5c3b
https://hdl.handle.net/20.500.11820/08848b9f-c202-4ce6-8ed6-4cf1474e5c3b
Autor:
Urs Scherrer, Pierre Dessen, Emrush Rexhaj, David Cerny, Stefano F. Rimoldi, Yves Allemann, Agim Pireva, Ariane Paoloni-Giacobino, Claudio Sartori
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
American Journal of Physiology. Heart and Circulatory Physiology, Vol. 309, No 7 (2015) pp. H1151-H1156
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
American Journal of Physiology. Heart and Circulatory Physiology, Vol. 309, No 7 (2015) pp. H1151-H1156
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Assisted reproductive technologies (ART) induce vascular dysfunction in humans and mice. In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13da4b294b26a37ea435a6982e6c7c9a
Autor:
Aristotelis Chatziioannou, Micheline Kirsch-Volders, James M. Flanagan, Soterios A. Kyrtopoulos, Vincent T. Cunliffe, Paolo Vineis, Mark A. Hanson
Publikováno v:
The FASEB Journal
Exposure to environmental stressors, toxicants, and nutrient deficiencies can affect DNA in several ways. Some exposures cause damage and alter the structure of DNA, but there is increasing evidence that the same or other environmental exposures, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d0ac4dea2ebf49d79c20c8641ba353
https://pubmed.ncbi.nlm.nih.gov/28280003
https://pubmed.ncbi.nlm.nih.gov/28280003
Autor:
Michael R. Stratton, Eric Padron, Tingting Qin, Kenichi Yoshida, Eric Solary, Seishi Ogawa, Stéphanie Solier, Eric Jourdan, Serge Koscielny, Margot Morabito, William Vainchenker, Emilie Chautard, Dorothée Selimoglu-Buet, Jean-François Deleuze, Thérèse Commes, Kristen Meldi, Stéphane de Botton, Olivier Bernard, Claude Preudhomme, Pierre Fenaux, Marcel E. Dinger, Thorsten Braun, Mark J. Cowley, Bruno Quesnel, Vincent Meyer, Didier Auboeuf, François Artiguenave, Nathalie Droin, Maria E. Figueroa, Noémie Pata-Merci, Raphael Itzykson, Velimir Gayevskiy, Ludmil B. Alexandrov, Jane Merlevede
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
The cytidine analogues azacytidine and 5-aza-2'-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c49d85c0bfff4c676a3aec15934499b
https://hal.archives-ouvertes.fr/hal-03130526/document
https://hal.archives-ouvertes.fr/hal-03130526/document
Publikováno v:
Reproduction, Vol. 139, No 2 (2010) pp. 373-379
Endocrine-disrupting chemicals (EDCs), among which is the antiandrogen vinclozolin (VCZ), have been reported to affect the male reproductive system. In this study, VCZ was administered to pregnant mice at the time of embryo sex determination, and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e4c81a9323e28c02beef44383835b8
https://doi.org/10.1530/rep-09-0340
https://doi.org/10.1530/rep-09-0340
Autor:
Ludwig Stenz, Emmanuel Somm, Alexandre Dayer, Julien Prados, Christelle Stouder, Ariane Paoloni-Giacobino
Publikováno v:
PLoS ONE
PLOS ONE, Vol. 10, No 8 (2015) P. e0132136
Plos One, vol. 10, no. 7, pp. e0132136
PLoS ONE, Vol 10, Iss 7, p e0132136 (2015)
PLOS ONE, Vol. 10, No 8 (2015) P. e0132136
Plos One, vol. 10, no. 7, pp. e0132136
PLoS ONE, Vol 10, Iss 7, p e0132136 (2015)
Di-(2-ethylhexyl)phtalate (DEHP) is a plasticizer with endocrine disrupting properties found ubiquitously in the environment and altering reproduction in rodents. Here we investigated the impact of prenatal exposure to DEHP on spermatogenesis and DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc2a2e1e230b7cec4b1e5eab3e77136
http://europepmc.org/articles/PMC4526524
http://europepmc.org/articles/PMC4526524
Autor:
Anna Enjuanes, Felipe Prosper, Amaia Lujambio, Itziar Salaverria, Xabier Agirre, Manel Esteller, Jara Palomero, Elias Campo, Silvia Xargay-Torrent, Cristina Royo, Virginia Amador, Andreas Rosenwald, José I. Martín-Subero, Sílvia Beà, Reiner Siebert, Idoia Martin-Guerrero, Balázs Bálint, German Ott, Jose Roman-Gomez, Maria Carmela Vegliante, Julia Richter, Luis Hernández, Pedro Jares, María José Calasanz
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
Recercat. Dipósit de la Recerca de Catalunya
PLoS ONE, Vol 6, Iss 6, p e21382 (2011)
instname
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
Recercat. Dipósit de la Recerca de Catalunya
PLoS ONE, Vol 6, Iss 6, p e21382 (2011)
Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d560c08b3d8fce5775972662fa295eac
https://hdl.handle.net/10171/35418
https://hdl.handle.net/10171/35418
Autor:
Wing C. Chan, Timothy W. McKeithan, Javeed Iqbal, Phillip Gaulard, Laurence de Leval, Wing Y. Au, Can Küçük, Gopesh Srivastava, Xiaozhou Hu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (50), pp.20119-24. ⟨10.1073/pnas.1115128108⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 50, pp. 20119-20124
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (50), pp.20119-24. ⟨10.1073/pnas.1115128108⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 50, pp. 20119-20124
Natural killer cell lymphoma (NKCL) constitutes a rare and aggressive form of non-Hodgkin lymphoma, and there is little insight into its pathogenesis. Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inactivated by a combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd576552b295a146ea5212abd8eb9ab7
https://doi.org/10.1073/pnas.1115128108
https://doi.org/10.1073/pnas.1115128108