Zobrazeno 1 - 10
of 1 950
pro vyhledávání: '"DNA Integration"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract This study aimed to investigate whether the plant DNA damage levels and DNA damage response (DDR) are regulated during Agrobacterium infection and potentially manipulated by Agrobacterium to facilitate T-DNA integration. We investigated the
Externí odkaz:
https://doaj.org/article/2b55dcf9b80e4dfaafa4d0e1da100bf7
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract The global burden of hepatitis B virus (HBV) infection remains high, with chronic hepatitis B (CHB) patients facing a significantly increased risk of developing cirrhosis and hepatocellular carcinoma (HCC). The ultimate objective of antivira
Externí odkaz:
https://doaj.org/article/cbde962900c14c299c945f9066aff953
Autor:
L. S. Mkrtchian, V. I. Kiseleva, L. I. Krikunova, B. V. Boyko, V. R. Gusarova, G. P. Bezyaeva, L. V. Panarina, S. A. Ivanov, A. D. Kaprin, I. A. Zamulaeva
Publikováno v:
Южно-Российский онкологический журнал, Vol 5, Iss 2, Pp 53-65 (2024)
Purpose of the study. Study of the characteristics of human papillomavirus (HPV) infection, comparison of HPV status, molecular and genetic parameters of HPV high risk (HR) with the clinical and morphological characteristics of cervical cancer.Materi
Externí odkaz:
https://doaj.org/article/a4386af1b00c48b39ca31a21dc4e6903
Autor:
Juan-Juan Zhao, Xin-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin, Mei Zhao, Feng Zhang, Si-Ang Li, Zhi-Xue Yang, Wei Wen, Tao Cheng, An Gong, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively curing this disorder in
Externí odkaz:
https://doaj.org/article/6b00ee3c16a94b60a7273e094f61df57
Autor:
L. S. Mkrtchian, V. I. Kiseleva, B. V. Boyko, L. I. Krikunova, V. A. Petrov, V. R. Gusarova, S. A. Ivanov, A. D. Kaprin, I. A. Zamulaeva
Publikováno v:
Issledovaniâ i Praktika v Medicine, Vol 10, Iss 4, Pp 104-118 (2023)
Purpose of the study. Analysis of contemporary literature sources dedicated to the study of characteristics of high oncogenic risk human papillomavirus (HPV), associative links of the virus’s molecular-genetic parameters with the clinical and morph
Externí odkaz:
https://doaj.org/article/d142c49377a146b4aa72a86888f9be95
Publikováno v:
Viruses, Vol 16, Iss 9, p 1361 (2024)
Hepatitis B virus (HBV) infection remains a major public health concern worldwide, with approximately 296 million individuals chronically infected. The HBV-encoded X protein (HBx) is a regulatory protein of 17 kDa, reportedly responsible for a broad
Externí odkaz:
https://doaj.org/article/dd6fedcebb074966b795176281566fa4
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Prokaryotic evolution is driven by random mutations and horizontal gene transfer (HGT). HGT occurs via transformation, transduction, or conjugation. We have previously shown that in syntrophic cocultures of Clostridium acetobutylicum and Clo
Externí odkaz:
https://doaj.org/article/9b1de74a273c4bc2ae69bec0f693a3af
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Fruit rot caused by Colletotrichum magnum is a crucial watermelon disease threatening the production and quality. To understand the pathogenic mechanism of C. magnum, we optimized the Agrobacterium tumefaciens-mediated transformation system (ATMT) fo
Externí odkaz:
https://doaj.org/article/bc86ba6466d746e1b86e577e937fd769
Autor:
Yin Jianhang, Hu Jiazhi
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 54, Pp 767-781 (2022)
The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA breaks at the target sites and subse
Externí odkaz:
https://doaj.org/article/2e2dde7277a14695b1ab9bf8fa93e8f2
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