Výsledky vyhledávání - "DNA Fragmentation/drug effects"

Akademický článek

Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes

Autor: Thanaa Ahmed Elmasry, Nora Hamed Al-Shaalan, Ehab Tousson, Kadreya El-Morshedy, Areej Al-Ghadeer

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 1 (2018)

ABSTRACT Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. Th

Externí odkaz: https://doaj.org/article/f9a4940674a84add9000d3555ee5aa74

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Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes

Autor: Kadreya El-Morshedy, Areej Al-Ghadeer, Nora Hamed Al-Shaalan, Thanaa A. El-Masry, Ehab Tousson

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 1 (2018)
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e17261
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 1 (2018); e17261
Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 1 (2018); e17261
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Volume: 54, Issue: 1, Article number: e17261, Published: 07 JUN 2018

Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. The current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72e1d672009cae048e81fdccf2e8590
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100621&lng=en&tlng=en

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Pharmacological Inhibition of CB1Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity

Autor: Norma P. Gerard, George Kunos, Partha Mukhopadhyay, Mohanraj Rajesh, Pal Pacher, Zsuzsanna K. Zsengellér, Sandor Batkai, Nora Czifra, Judith Harvey-White, Lucas Liaudet, György Haskó

Publikováno v: Journal of the American College of Cardiology, vol. 50, no. 6, pp. 528-36

Objectives We aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity. Background Doxorubicin is one of the most potent antitumor agents avail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08e21e52c6e63f9e617b62a6caa6651

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Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells

Autor: Mostafa Heidari Majd, George Coukos, Davoud Asgari, Sajjad Khani, Jaleh Barar, Yadollah Omidi, Vala Kafil, Abolfazl Barzegari, Mohammad Johari-Ahar

Publikováno v: Journal of Nanobiotechnology
Journal of Nanobiotechnology, vol. 13, no. 1, pp. 26

BACKGROUND: Targeted delivery of anticancer chemotherapeutics such as mitoxantrone (MTX) can significantly intensify their cytotoxic effects selectively in solid tumors such as breast cancer. In the current study, folic acid (FA)-armed and MTX-conjug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1208dc80d45fac18042c57fecf4388
http://europepmc.org/articles/PMC4387580

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Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms

Autor: Ikram El Zaoui, Alicia Torriglia, Francine Behar-Cohen

Publikováno v: Toxicological Sciences, vol. 143, no. 2, pp. 441-453

Glucocorticoids (GCs) are routinely administered systemically or injected into the eye when treating numerous ocular diseases; however, their toxicity on the retinal microvasculature has not been previously investigated. In this article, the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e9cc38d9fa9880134d7452c309a05a
https://serval.unil.ch/notice/serval:BIB_EBC4BA09C322

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Akademický článek

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Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response

Autor: Basile Stamatopoulos, Martine Massy, Nathalie Meuleman, Marielle Dejeneffe, Laurence Lagneaux, Alain Delforge, Dominique Bron, Lucas Willems, Nicolas Gillet, Alain Kentos, Philippe Martiat

Publikováno v: Experimental hematology. 35(10)

[en] OBJECTIVE: Chronic lymphocytic leukemia (CLL) cells develop chemoresistance over time associated with defects in apoptosis pathway. Novel treatment strategies are required to overcome resistance of cells to commonly used agents. The effects of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428557618ed1fab5fd78f9b54ec51199
https://pubmed.ncbi.nlm.nih.gov/17697742

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Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

Autor: Ferrandi, Chiara, Ballerio, Rossana, Gaillard, Pascale, Giachetti, Claudio, Carboni, Sonia, Vitte, Pierre-Alain, Gotteland, Jean-Pierre, Cirillo, Rocco

Publikováno v: British Journal of Pharmacology, Vol. 142, No 6 (2004) pp. 953-960

1 Myocardial ischemia/reperfusion is associated with inflammation, apoptosis and necrosis. During this process, c-jun N-terminal kinase is activated in cardiac myocytes resulting in apoptosis. 2 This study investigates the effects of AS601245, a nonp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c7f08ba76cc4df9d077161d7beb0608d
https://archive-ouverte.unige.ch/unige:89904

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Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

Autor: Giatgen A. Spinas, Marc Y. Donath, Pascal Alain Robert Bucher, Kathrin Maedler, Jose Oberholzer

Publikováno v: Diabetes, Vol. 52, No 3 (2003) pp. 726-33

Glucotoxicity and lipotoxicity contribute to the impaired beta-cell function observed in type 2 diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different glucose concentrations on human beta-cell turnover and secr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65f0b7393bf2427581e7a854c0e888b
https://pubmed.ncbi.nlm.nih.gov/12606514

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