Zobrazeno 1 - 10
of 674
pro vyhledávání: '"DNA Dynamics and Chromosome Structure"'
Autor:
Sarah Lambert, Jackie A. Pearce, Peter J. McHugh, Sarah J. Mason, Louise J. Barber, Anthony M. Carr, John A. Hartley
Drugs that produce covalent interstrand cross-links (ICLs) in DNA remain central to the treatment of cancer, but the cell cycle checkpoints activated by ICLs have received little attention. We have used the fission yeast, Schizosaccharomyces pombe, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1278b4f5e37adb440084da9c034dbc7e
https://ora.ox.ac.uk/objects/uuid:dd7ff598-3167-420a-9791-25fd9549d42d
https://ora.ox.ac.uk/objects/uuid:dd7ff598-3167-420a-9791-25fd9549d42d
Autor:
Keiko Namikoshi, Mitsuyoshi Yamazoe, Kazuhiko Yamamoto, Kazunaga Agematsu, Jean-Marie Buerstedde, Shunichi Takeda, Hiroshi Arakawa, Masamichi Ishiai, Masayo Kimura, Nobuko Matsushita, Minoru Takata
Publikováno v:
Molecular and Cellular Biology. 24:10733-10741
DNA interstrand cross-links (ICLs) covalently bind the two complementary strands of the double helix of DNA. They severely impair fundamental processes of DNA metabolism such as transcription or replication, leading to cell death if they are left unr
Autor:
Elizabeth H. Blackburn, Daniel L. Levy
Publikováno v:
Molecular and Cellular Biology. 24:10857-10867
Telomere length is negatively regulated by proteins of the telomeric DNA-protein complex. Rap1p in Saccharomyces cerevisiae binds the telomeric TG(1-3) repeat DNA, and the Rap1p C terminus interacts with Rif1p and Rif2p. We investigated how these thr
Publikováno v:
Molecular and Cellular Biology. 24:10208-10222
Cyclin-dependent kinase (CDK) is required for the initiation of chromosomal DNA replication in eukaryotes. In Saccharomyces cerevisiae, the Clb5 and Clb6 cyclins activate Cdk1 and drive replication origin firing. Deletion of CLB5 reduces initiation o
Publikováno v:
Molecular and Cellular Biology. 24:9305-9316
Repair of chromosomal breaks is essential for cellular viability, but misrepair generates mutations and gross chromosomal rearrangements. We investigated the interrelationship between two homologous-repair pathways, i.e., mutagenic single-strand anne
Autor:
Yeon-Soo Seo, Masaru Ueno, Takashi Ushimaru, Kazunori Tomita, Masahiro Uritani, Hoyoung Kang, Tatsuya Kibe
Publikováno v:
Molecular and cellular biology. 24:9557-9567
It has been suggested that the Schizosaccharomyces pombe Rad50 (Rad50-Rad32-Nbs1) complex is required for the resection of the C-rich strand at telomere ends in taz1-d cells. However, the nuclease-deficient Rad32-D25A mutant can still resect the C-ri
Autor:
Carolyn M. Price, Manu De Rycker
Publikováno v:
Molecular and Cellular Biology. 24:9802-9812
Tankyrases are novel poly(ADP-ribose) polymerases that have SAM and ankyrin protein-interaction domains. They are found at telomeres, centrosomes, nuclear pores, and Golgi vesicles and have been shown to participate in telomere length regulation. The
Publikováno v:
Molecular and Cellular Biology. 24:10047-10057
A minimal amount of extranucleosomal DNA was required for nucleosome mobilization by ISW2 as shown by using a photochemical histone mapping approach to analyze nucleosome movement on a set of nucleosomes with varied lengths of extranucleosomal DNA. I
Publikováno v:
Molecular and Cellular Biology. 24:9813-9822
DNA recombination required for mating type (mat1) switching in Schizosaccharomyces pombe is initiated by mat1 imprinting. The imprinting event is regulated by mat1 cis-acting elements and by several trans-acting factors, including swi1 (for switch),
Publikováno v:
Molecular and Cellular Biology. 24:10016-10025
The large protein kinases, ataxia-telangiectasia mutated (ATM) and ATM-Rad3-related (ATR), orchestrate DNA damage checkpoint pathways. In budding yeast, ATM and ATR homologs are encoded by TEL1 and MEC1, respectively. The Mre11 complex consists of tw