In Vivo Identification of Adducts from the New Hypoxia-Activated Prodrug CP-506 Using DNA Adductomics

Autor: Morwena J. Solivio, Alessia Stornetta, Julie Gilissen, Peter W. Villalta, Sofie Deschoemaeker, Arne Heyerick, Ludwig Dubois, Silvia Balbo

Publikováno v: Chemical Research in Toxicology, 35(2), 275-282. American Chemical Society

Many chemotherapeutic drugs exert their cytotoxicity through the formation of DNA modifications (adducts), which interfere with DNA replication, an overactive process in rapidly dividing cancer cells. Side effects from the therapy are common, however

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff84922cf533120ef66599dbfa0717e8
https://doi.org/10.1021/acs.chemrestox.1c00329

Prevalence of Mycobacterium leprae in armadillos in Brazil: A systematic review and meta-analysis

Autor: Patrícia Duarte Deps, Adalberto R. Santos, João Marcelo Azevedo de Paula Antunes, Simon M Collin

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008127 (2020)
Deps, P, Antunes, J M, Santos, A R & Collin, S M 2020, ' Prevalence of Mycobacterium leprae in armadillos in Brazil : A systematic review and meta-analysis ', PLoS Neglected Tropical Diseases, vol. 14, no. 3, e0008127 . https://doi.org/10.1371/journal.pntd.0008127
PLoS Neglected Tropical Diseases

Understanding the prevalence of M. leprae infection in armadillos is important because of evidence from Brazil and other countries of an association between contact with armadillos and the development of Hansen’s Disease (leprosy). Our aim was to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa1ed744a545862147c93918116e82e
https://doi.org/10.1371/journal.pntd.0008127

Detection of Chlamydiaceae and Chlamydia-like organisms on the ocular surface of children and adults from a trachoma-endemic region

Autor: Darja Keše, Hadeel Alchalabi, Gilbert Greub, Nicole Borel, Nadine Schuerer, Elisabeth Stein, Aleksandra Inic-Kanada, Astrid Collingro, Talin Barisani-Asenbauer, Florian Tagini, Balgesa Elkheir Babiker, Ehsan Ghasemian

Publikováno v: Scientific reports, vol. 8, no. 1, pp. 7432
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports

Trachoma, the leading infectious cause of blindness, is caused by Chlamydia trachomatis (Ct), a bacterium of the phylum Chlamydiae. Recent investigations revealed the existence of additional families within the phylum Chlamydiae, also termed Chlamydi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfa5bd2f7e356e6df8e6f8207c2ac0d
https://doi.org/10.1038/s41598-018-23887-1

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Autor: Robert J. Wilkinson, James E. Bower, Liliana K. Rutaihwa, W. Henry Boom, Matthias Egger, Philip Noel Suffys, Elisabeth Sanchez-Padilla, Linda Gail-Bekker, Sebastien Gagneux, Issam Alani, Marie Ballif, Kathleen D. Eisenach, Jennifer L. Guthrie, Ana Gil-Brusola, Eddie M. Wampande, Willy Ssengooba, Nyanda E. Ntinginya, Rita Macedo, Petras Stakenas, Bijaya Malla, Adwoa Asante-Poku, Stefan Niemann, Lynsey Stewart-Isherwood, Mireia Coscolla, Perpetual Wangui Ndung'u, Florian Gehre, Daniela Maria Cirillo, E. Jane Carter, Sidra Ezidio Gonçalves Vasconcellos, Moses Joloba, Midori Kato-Maeda, Indira Basu, Andrea Rachow, Bouke C. de Jong, Serej D. Ley, Andrej Trauner, Hans-Peter Beck, Jackson Thomas, Dorothy Yeboah-Manu, Qingyun Liu, Tao Luo, Francesca Barletta, Véronique Penlap Beng, Janet A. M. Fyfe, Anastasia Koch, Margarida Saraiva, Sven Hoffner, Daniela Brites, Sahal Al-Hajoj, Griselda Tudo Vilanova, Maria Globan, Qian Gao, Helmi Mardassi, Maryline Bonnet, Philip Supply, Iñaki Comas, Valeriu Crudu, Girts Skenders, Francine Ntoumi, Frances B. Jamieson, Olga Domnica Moldovan, Leïla Jeljeli, Gunturu Revathi, Milagros Moreno, Suriya Akter, Sonia Borrell, Kadri Toit, Matthias Frank, Michael Hoelscher, Lameck Diero, Daiva Bakonyte, David Stucki, Lukas Fenner, Larissa Otero, Roland Diel

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Genetics
Nature Genetics, Nature Publishing Group, 2016, ⟨10.1038/ng.3704⟩
NATURE GENETICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
Nature genetics
Nature Genetics, 2016, ⟨10.1038/ng.3704⟩

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f812bf436e582bce990680d73fa18f89

Role ofChlamydia trachomatisin Miscarriage

Autor: Gilbert Greub, Patrick Hohlfeld, Yvan Vial, Nicole Borel, Andreas Pospischil, Serafin Blumer, Maria-Chiara Osterheld, David Baud, Genevieve Goy, Katia Jaton

Publikováno v: Emerging Infectious Diseases, Vol 17, Iss 9, Pp 1630-1635 (2011)
Emerging Infectious Diseases, vol. 17, no. 9, pp. 1630-1635
Emerging Infectious Diseases

TOC Summary: Women experiencing miscarriage should be screened for C. trachomatis.
To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 wom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005300c52614f53102b748dda5f9d960
https://doi.org/10.3201/eid1709.100865